| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | TFCP2 | Ser309 | SLGEGNGsPNHQPEP | dephosphorylation up-regulates | 20682773 | SIGNOR-167389 |
| MAPK3 | TFCP2 | Ser309 | SLGEGNGsPNHQPEP | phosphorylation down-regulates | 19237534 | SIGNOR-184180 |
| CyclinC/CDK3 | TFCP2 | Ser309 | SLGEGNGsPNHQPEP | phosphorylation down-regulates activity | 19237534 | SIGNOR-273180 |
| MAPK1 | TFCP2 | Ser309 | SLGEGNGsPNHQPEP | phosphorylation down-regulates | 19237534 | SIGNOR-184172 |
| CyclinE/CDK2 | TFCP2 | Ser309 | SLGEGNGsPNHQPEP | phosphorylation down-regulates | 19237534 | SIGNOR-216713 |
| CDK3 | TFCP2 | Ser309 | SLGEGNGsPNHQPEP | phosphorylation down-regulates | 19237534 | SIGNOR-184164 |
| CDK2 | TFCP2 | Ser309 | SLGEGNGsPNHQPEP | phosphorylation down-regulates | 19237534 | SIGNOR-184160 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates ⊣ | TFCP2 PSer309 | dephosphorylation down-regulates ⊣ | TFCP2 | 20682773 | SIGNOR-167389 |
| MAPK3 | phosphorylation up-regulates → | TFCP2 PSer309 | phosphorylation down-regulates ⊣ | TFCP2 | 19237534 | SIGNOR-184180 |
| CyclinC/CDK3 | phosphorylation up-regulates → | TFCP2 PSer309 | phosphorylation down-regulates ⊣ | TFCP2 | 19237534 | SIGNOR-273180 |
| MAPK1 | phosphorylation up-regulates → | TFCP2 PSer309 | phosphorylation down-regulates ⊣ | TFCP2 | 19237534 | SIGNOR-184172 |
| CyclinE/CDK2 | phosphorylation up-regulates → | TFCP2 PSer309 | phosphorylation down-regulates ⊣ | TFCP2 | 19237534 | SIGNOR-216713 |
| CDK3 | phosphorylation up-regulates → | TFCP2 PSer309 | phosphorylation down-regulates ⊣ | TFCP2 | 19237534 | SIGNOR-184164 |
| CDK2 | phosphorylation up-regulates → | TFCP2 PSer309 | phosphorylation down-regulates ⊣ | TFCP2 | 19237534 | SIGNOR-184160 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CA | dephosphorylation → up-regulates | TFCP2 | SIGNOR-167389 |
| MAPK3 | phosphorylation down-regulates | TFCP2 | SIGNOR-184180 |
| CyclinC/CDK3 | phosphorylation → down-regulates activity | TFCP2 | SIGNOR-273180 |
| MAPK1 | phosphorylation down-regulates | TFCP2 | SIGNOR-184172 |
| CyclinE/CDK2 | phosphorylation down-regulates | TFCP2 | SIGNOR-216713 |
| CDK3 | phosphorylation down-regulates | TFCP2 | SIGNOR-184164 |
| CDK2 | phosphorylation down-regulates | TFCP2 | SIGNOR-184160 |
