Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PRKACA	KCNH2	Ser1137 View in OncoXplorer	EGPTRRLsLPGQLGA	phosphorylation up-regulates	10488078	SIGNOR-70718
PRKACA	KCNH2	Ser890	RQRKRKLsFRRRTDK	phosphorylation up-regulates	10488078	SIGNOR-70726
PRKACA	KCNH2	Ser283	CASVRRAsSADDIEA	phosphorylation up-regulates	10488078	SIGNOR-70722
PTPN6	KCNH2	–		dephosphorylation down-regulates	12361947	SIGNOR-94007
PRKACA	KCNH2	Thr895	KLSFRRRtDKDTEQP	phosphorylation up-regulates	10488078	SIGNOR-70730
PRKD1	KCNH2	Ser284	ASVRRASsADDIEAM	phosphorylation down-regulates activity	29949809	SIGNOR-277612

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PRKACA	phosphorylation up-regulates →	KCNH2 PSer1137	phosphorylation up-regulates →	KCNH2	10488078	SIGNOR-70718
PRKACA	phosphorylation up-regulates →	KCNH2 PSer890	phosphorylation up-regulates →	KCNH2	10488078	SIGNOR-70726
PRKACA	phosphorylation up-regulates →	KCNH2 PSer283	phosphorylation up-regulates →	KCNH2	10488078	SIGNOR-70722
PRKACA	phosphorylation up-regulates →	KCNH2 PThr895	phosphorylation up-regulates →	KCNH2	10488078	SIGNOR-70730
PRKD1	phosphorylation up-regulates →	KCNH2 PSer284	phosphorylation down-regulates ⊣	KCNH2	29949809	SIGNOR-277612

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PRKACA	phosphorylation → up-regulates	KCNH2	SIGNOR-70718
PRKACA	phosphorylation → up-regulates	KCNH2	SIGNOR-70726
PRKACA	phosphorylation → up-regulates	KCNH2	SIGNOR-70722
PTPN6	dephosphorylation down-regulates	KCNH2	SIGNOR-94007
PRKACA	phosphorylation → up-regulates	KCNH2	SIGNOR-70730
PRKD1	phosphorylation → down-regulates activity	KCNH2	SIGNOR-277612