| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TBK1 | CDC20 | – | phosphorylation down-regulates activity | 33310066 | SIGNOR-279766 | |
| BUB1 | CDC20 | Ser72 | SKVQTTPsKPGGDRY | phosphorylation down-regulates activity | 15525512 | SIGNOR-250607 |
| CDK1 | CDC20 | – | phosphorylation down-regulates activity | 29971233 | SIGNOR-279321 | |
| NEK2 | CDC20 | – | phosphorylation up-regulates activity | 20034488 | SIGNOR-278366 | |
| AURKB | CDC20 | – | phosphorylation down-regulates activity | 28434146 | SIGNOR-280190 | |
| BUB1 | CDC20 | Thr157 | VLYSQKAtPGSSRKT | phosphorylation down-regulates activity | 15525512 | SIGNOR-250609 |
| PLK1 | CDC20 | Ser170 | KTCRYIPsLPDRILD | phosphorylation down-regulates quantity by destabilization | 23643811 | SIGNOR-276493 |
| BUB1B | CDC20 | – | phosphorylation up-regulates activity | 11030144 | SIGNOR-279507 | |
| BUB1 | CDC20 | Ser41 | EAAGPAPsPMRAANR | phosphorylation down-regulates activity | 15525512 | SIGNOR-250606 |
| CDK2 | CDC20 | – | phosphorylation down-regulates activity | 26960431 | SIGNOR-279322 | |
| BUB1 | CDC20 | Ser92 | AAQMEVAsFLLSKEN | phosphorylation down-regulates activity | 15525512 | SIGNOR-250608 |
| BUB1 | CDC20 | Ser161 | QKATPGSsRKTCRYI | phosphorylation down-regulates activity | 15525512 | SIGNOR-250605 |
| BUB1 | CDC20 | Ser153 | NRLKVLYsQKATPGS | phosphorylation down-regulates activity | 15525512 | SIGNOR-250604 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BUB1 | phosphorylation up-regulates → | CDC20 PSer72 | phosphorylation down-regulates ⊣ | CDC20 | 15525512 | SIGNOR-250607 |
| BUB1 | phosphorylation up-regulates → | CDC20 PThr157 | phosphorylation down-regulates ⊣ | CDC20 | 15525512 | SIGNOR-250609 |
| PLK1 | phosphorylation up-regulates → | CDC20 PSer170 | phosphorylation down-regulates ⊣ | CDC20 | 23643811 | SIGNOR-276493 |
| BUB1 | phosphorylation up-regulates → | CDC20 PSer41 | phosphorylation down-regulates ⊣ | CDC20 | 15525512 | SIGNOR-250606 |
| BUB1 | phosphorylation up-regulates → | CDC20 PSer92 | phosphorylation down-regulates ⊣ | CDC20 | 15525512 | SIGNOR-250608 |
| BUB1 | phosphorylation up-regulates → | CDC20 PSer161 | phosphorylation down-regulates ⊣ | CDC20 | 15525512 | SIGNOR-250605 |
| BUB1 | phosphorylation up-regulates → | CDC20 PSer153 | phosphorylation down-regulates ⊣ | CDC20 | 15525512 | SIGNOR-250604 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TBK1 | phosphorylation → down-regulates activity | CDC20 | SIGNOR-279766 |
| BUB1 | phosphorylation → down-regulates activity | CDC20 | SIGNOR-250607 |
| CDK1 | phosphorylation → down-regulates activity | CDC20 | SIGNOR-279321 |
| NEK2 | phosphorylation → up-regulates activity | CDC20 | SIGNOR-278366 |
| AURKB | phosphorylation → down-regulates activity | CDC20 | SIGNOR-280190 |
| BUB1 | phosphorylation → down-regulates activity | CDC20 | SIGNOR-250609 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CDC20 | SIGNOR-276493 |
| BUB1B | phosphorylation → up-regulates activity | CDC20 | SIGNOR-279507 |
| BUB1 | phosphorylation → down-regulates activity | CDC20 | SIGNOR-250606 |
| CDK2 | phosphorylation → down-regulates activity | CDC20 | SIGNOR-279322 |
| BUB1 | phosphorylation → down-regulates activity | CDC20 | SIGNOR-250608 |
| BUB1 | phosphorylation → down-regulates activity | CDC20 | SIGNOR-250605 |
| BUB1 | phosphorylation → down-regulates activity | CDC20 | SIGNOR-250604 |
