Entity Details

Name MERTK
ID Q12866
Role kinase
Enzymatic Domains
Ig-like C2-type 1 81-186
Ig-like C2-type 2 197-273
Fibronectin type-III 1 286-381
PROSITE-ProRule
Fibronectin type-III 2 386-484
PROSITE-ProRule
Protein kinase 587-858
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MERTKMERTKTyr749FGLSKKIySGDYYRQphosphorylation
up-regulates		8702477SIGNOR-42914
MERTKMERTKTyr753KKIYSGDyYRQGRIAphosphorylation
up-regulates		8702477SIGNOR-42918
MERTKMERTKTyr754KIYSGDYyRQGRIAKphosphorylation
up-regulates		8702477SIGNOR-42922
MERTKMLKLTyr376DRVKSTAyLSPQELEphosphorylation
up-regulates quantity by stabilization		31230815SIGNOR-274118
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MERTKphosphorylation
up-regulates
→
MERTK
PTyr749		phosphorylation
up-regulates
→		MERTK8702477SIGNOR-42914
MERTKphosphorylation
up-regulates
→
MERTK
PTyr753		phosphorylation
up-regulates
→		MERTK8702477SIGNOR-42918
MERTKphosphorylation
up-regulates
→
MERTK
PTyr754		phosphorylation
up-regulates
→		MERTK8702477SIGNOR-42922
MERTKphosphorylation
up-regulates
→
MLKL
PTyr376		phosphorylation
up-regulates
→		MLKL31230815SIGNOR-274118
Regulator Mechanism/Effect Target SIGNOR-ID
MERTKphosphorylation
→
up-regulates 		MERTKSIGNOR-42914
MERTKphosphorylation
→
up-regulates 		MERTKSIGNOR-42918
MERTKphosphorylation
→
up-regulates 		MERTKSIGNOR-42922
MERTKphosphorylation
→
up-regulates quantity by stabilization 		MLKLSIGNOR-274118