| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | GRIN2A | Tyr1105 | CSEVERTyLKTKSSS | phosphorylation up-regulates activity | 10195142 | SIGNOR-247163 |
| FYN | GRIN2A | Tyr1267 | PATGEQVyQQDWAQN | phosphorylation up-regulates activity | 10195142 | SIGNOR-247155 |
| PRKCA | GRIN2A | Ser1416 | ASYCSRDsRGHNDVY | phosphorylation unknown | 11104776 | SIGNOR-249065 |
| FYN | GRIN2A | Tyr1325 | RLLEGNFyGSLFSVP | phosphorylation up-regulates | 19834457 | SIGNOR-188527 |
| FYN | GRIN2A | Tyr1105 | CSEVERTyLKTKSSS | phosphorylation up-regulates activity | 10195142 | SIGNOR-247151 |
| SRC | GRIN2A | Tyr1267 | PATGEQVyQQDWAQN | phosphorylation up-regulates activity | 10195142 | SIGNOR-247167 |
| CDK5 | GRIN2A | Ser1232 | SGHFTMRsPFKCDAC | phosphorylation up-regulates activity | 11675505 | SIGNOR-250666 |
| DYRK1A | GRIN2A | Ser1048 | NRTHSLKsPRYLPEE | phosphorylation up-regulates quantity | 25368549 | SIGNOR-279327 |
| FYN | GRIN2A | Tyr1387 | GRCPSDPyKHSLPSQ | phosphorylation up-regulates activity | 10195142 | SIGNOR-247159 |
| PTPN5 | GRIN2A | – | dephosphorylation down-regulates activity | 27857196 | SIGNOR-277089 | |
| SRC | GRIN2A | Tyr1325 | RLLEGNFyGSLFSVP | phosphorylation up-regulates | 19834457 | SIGNOR-188531 |
| SRC | GRIN2A | Tyr1387 | GRCPSDPyKHSLPSQ | phosphorylation up-regulates activity | 10195142 | SIGNOR-247171 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | phosphorylation up-regulates → | GRIN2A PTyr1105 | phosphorylation up-regulates → | GRIN2A | 10195142 | SIGNOR-247163 |
| FYN | phosphorylation up-regulates → | GRIN2A PTyr1267 | phosphorylation up-regulates → | GRIN2A | 10195142 | SIGNOR-247155 |
| PRKCA | phosphorylation up-regulates → | GRIN2A PSer1416 | phosphorylation down-regulates ⊣ | GRIN2A | 11104776 | SIGNOR-249065 |
| FYN | phosphorylation up-regulates → | GRIN2A PTyr1325 | phosphorylation up-regulates → | GRIN2A | 19834457 | SIGNOR-188527 |
| FYN | phosphorylation up-regulates → | GRIN2A PTyr1105 | phosphorylation up-regulates → | GRIN2A | 10195142 | SIGNOR-247151 |
| SRC | phosphorylation up-regulates → | GRIN2A PTyr1267 | phosphorylation up-regulates → | GRIN2A | 10195142 | SIGNOR-247167 |
| CDK5 | phosphorylation up-regulates → | GRIN2A PSer1232 | phosphorylation up-regulates → | GRIN2A | 11675505 | SIGNOR-250666 |
| DYRK1A | phosphorylation up-regulates → | GRIN2A PSer1048 | phosphorylation up-regulates → | GRIN2A | 25368549 | SIGNOR-279327 |
| FYN | phosphorylation up-regulates → | GRIN2A PTyr1387 | phosphorylation up-regulates → | GRIN2A | 10195142 | SIGNOR-247159 |
| SRC | phosphorylation up-regulates → | GRIN2A PTyr1325 | phosphorylation up-regulates → | GRIN2A | 19834457 | SIGNOR-188531 |
| SRC | phosphorylation up-regulates → | GRIN2A PTyr1387 | phosphorylation up-regulates → | GRIN2A | 10195142 | SIGNOR-247171 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SRC | phosphorylation → up-regulates activity | GRIN2A | SIGNOR-247163 |
| FYN | phosphorylation → up-regulates activity | GRIN2A | SIGNOR-247155 |
| PRKCA | phosphorylation → unknown | GRIN2A | SIGNOR-249065 |
| FYN | phosphorylation → up-regulates | GRIN2A | SIGNOR-188527 |
| FYN | phosphorylation → up-regulates activity | GRIN2A | SIGNOR-247151 |
| SRC | phosphorylation → up-regulates activity | GRIN2A | SIGNOR-247167 |
| CDK5 | phosphorylation → up-regulates activity | GRIN2A | SIGNOR-250666 |
| DYRK1A | phosphorylation → up-regulates quantity | GRIN2A | SIGNOR-279327 |
| FYN | phosphorylation → up-regulates activity | GRIN2A | SIGNOR-247159 |
| PTPN5 | dephosphorylation → down-regulates activity | GRIN2A | SIGNOR-277089 |
| SRC | phosphorylation → up-regulates | GRIN2A | SIGNOR-188531 |
| SRC | phosphorylation → up-regulates activity | GRIN2A | SIGNOR-247171 |
