| Name | TP53BP1 |
| ID | Q12888 |
| Role | substrate |
| Enzymatic Domains |
BRCT 1 1724-1848 PROSITE-ProRule
BRCT 2 1864-1964 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | TP53BP1 | Thr543 | IDEDGENtQIEDTEP | dephosphorylation down-regulates activity | 31619012 | SIGNOR-277046 |
| ATM | TP53BP1 | Ser831 | EPVEQDSsQPSLPLV | phosphorylation up-regulates | 22621922 | SIGNOR-197615 |
| VRK1 | TP53BP1 | – | phosphorylation up-regulates | 22621922 | SIGNOR-197625 | |
| ATM | TP53BP1 | Ser29 | IEDSQPEsQVLEDDS | phosphorylation unknown | 12697768 | SIGNOR-100645 |
| MAPK12 | TP53BP1 | Thr1609 | LGPYEAVtPLTKAAD | phosphorylation down-regulates activity | 24703952 | SIGNOR-264448 |
| ATM | TP53BP1 | Ser784 | GVEKCSDsQSWEDIA | phosphorylation unknown | 12697768 | SIGNOR-100653 |
| AURKB | TP53BP1 | Ser1342 | GPLRGKTsGTEPADF | phosphorylation up-regulates activity | 28415769 | SIGNOR-264411 |
| MAPK11 | TP53BP1 | Thr1609 | LGPYEAVtPLTKAAD | phosphorylation down-regulates activity | 24703952 | SIGNOR-264447 |
| ATM | TP53BP1 | Ser6 | sQLDSDFS | phosphorylation unknown | 12697768 | SIGNOR-100649 |
| PLK1 | TP53BP1 | Ser1618 | LTKAADIsLDNLVEG | phosphorylation down-regulates activity | 24703952 | SIGNOR-264413 |
| CyclinB/CDK1 | TP53BP1 | Ser1678 | ITSEEERsPAKRGRK | phosphorylation down-regulates activity | 30685087 | SIGNOR-264444 |
| MAPK14 | TP53BP1 | Thr1609 | LGPYEAVtPLTKAAD | phosphorylation down-regulates activity | 24703952 | SIGNOR-264446 |
| ATM | TP53BP1 | – | phosphorylation up-regulates | 22621922 | SIGNOR-197622 | |
| CDK1 | TP53BP1 | Ser1678 | ITSEEERsPAKRGRK | phosphorylation down-regulates activity | 30685087 | SIGNOR-264412 |
| ATM | TP53BP1 | Ser25 | PCLIIEDsQPESQVL | phosphorylation unknown | 12697768 | SIGNOR-100641 |
| PPP4C | TP53BP1 | Ser1618 | LTKAADIsLDNLVEG | dephosphorylation up-regulates activity | 24703952 | SIGNOR-264451 |
| PPP4C | TP53BP1 | Thr1609 | LGPYEAVtPLTKAAD | dephosphorylation up-regulates activity | 24703952 | SIGNOR-264450 |
| ATM | TP53BP1 | Thr302 | PEPEVLStQEDLFDQ | phosphorylation up-regulates | 22621922 | SIGNOR-197619 |
| p38 | TP53BP1 | Thr1609 | LGPYEAVtPLTKAAD | phosphorylation down-regulates activity | 24703952 | SIGNOR-264445 |
| GSK3B | TP53BP1 | Ser166 | GAEDTASsQLGFGVL | phosphorylation up-regulates activity | 29328365 | SIGNOR-278226 |
| MAPK13 | TP53BP1 | Thr1609 | LGPYEAVtPLTKAAD | phosphorylation down-regulates activity | 24703952 | SIGNOR-264449 |
| ATM | TP53BP1 | Ser1219 | DDTESLHsQGEEEFD | phosphorylation up-regulates | 22621922 | SIGNOR-197611 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | dephosphorylation down-regulates ⊣ | TP53BP1 PThr543 | dephosphorylation up-regulates → | TP53BP1 | 31619012 | SIGNOR-277046 |
| ATM | phosphorylation up-regulates → | TP53BP1 PSer831 | phosphorylation up-regulates → | TP53BP1 | 22621922 | SIGNOR-197615 |
| ATM | phosphorylation up-regulates → | TP53BP1 PSer29 | phosphorylation down-regulates ⊣ | TP53BP1 | 12697768 | SIGNOR-100645 |
| MAPK12 | phosphorylation up-regulates → | TP53BP1 PThr1609 | phosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264448 |
| ATM | phosphorylation up-regulates → | TP53BP1 PSer784 | phosphorylation down-regulates ⊣ | TP53BP1 | 12697768 | SIGNOR-100653 |
| AURKB | phosphorylation up-regulates → | TP53BP1 PSer1342 | phosphorylation up-regulates → | TP53BP1 | 28415769 | SIGNOR-264411 |
| MAPK11 | phosphorylation up-regulates → | TP53BP1 PThr1609 | phosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264447 |
| ATM | phosphorylation up-regulates → | TP53BP1 PSer6 | phosphorylation down-regulates ⊣ | TP53BP1 | 12697768 | SIGNOR-100649 |
| PLK1 | phosphorylation up-regulates → | TP53BP1 PSer1618 | phosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264413 |
| CyclinB/CDK1 | phosphorylation up-regulates → | TP53BP1 PSer1678 | phosphorylation down-regulates ⊣ | TP53BP1 | 30685087 | SIGNOR-264444 |
| MAPK14 | phosphorylation up-regulates → | TP53BP1 PThr1609 | phosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264446 |
| CDK1 | phosphorylation up-regulates → | TP53BP1 PSer1678 | phosphorylation down-regulates ⊣ | TP53BP1 | 30685087 | SIGNOR-264412 |
| ATM | phosphorylation up-regulates → | TP53BP1 PSer25 | phosphorylation down-regulates ⊣ | TP53BP1 | 12697768 | SIGNOR-100641 |
| PPP4C | dephosphorylation down-regulates ⊣ | TP53BP1 PSer1618 | dephosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264451 |
| PPP4C | dephosphorylation down-regulates ⊣ | TP53BP1 PThr1609 | dephosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264450 |
| ATM | phosphorylation up-regulates → | TP53BP1 PThr302 | phosphorylation up-regulates → | TP53BP1 | 22621922 | SIGNOR-197619 |
| p38 | phosphorylation up-regulates → | TP53BP1 PThr1609 | phosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264445 |
| GSK3B | phosphorylation up-regulates → | TP53BP1 PSer166 | phosphorylation up-regulates → | TP53BP1 | 29328365 | SIGNOR-278226 |
| MAPK13 | phosphorylation up-regulates → | TP53BP1 PThr1609 | phosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264449 |
| ATM | phosphorylation up-regulates → | TP53BP1 PSer1219 | phosphorylation up-regulates → | TP53BP1 | 22621922 | SIGNOR-197611 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1D | dephosphorylation → down-regulates activity | TP53BP1 | SIGNOR-277046 |
| ATM | phosphorylation → up-regulates | TP53BP1 | SIGNOR-197615 |
| VRK1 | phosphorylation → up-regulates | TP53BP1 | SIGNOR-197625 |
| ATM | phosphorylation → unknown | TP53BP1 | SIGNOR-100645 |
| MAPK12 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264448 |
| ATM | phosphorylation → unknown | TP53BP1 | SIGNOR-100653 |
| AURKB | phosphorylation → up-regulates activity | TP53BP1 | SIGNOR-264411 |
| MAPK11 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264447 |
| ATM | phosphorylation → unknown | TP53BP1 | SIGNOR-100649 |
| PLK1 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264413 |
| CyclinB/CDK1 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264444 |
| MAPK14 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264446 |
| ATM | phosphorylation → up-regulates | TP53BP1 | SIGNOR-197622 |
| CDK1 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264412 |
| ATM | phosphorylation → unknown | TP53BP1 | SIGNOR-100641 |
| PPP4C | dephosphorylation → up-regulates activity | TP53BP1 | SIGNOR-264451 |
| PPP4C | dephosphorylation → up-regulates activity | TP53BP1 | SIGNOR-264450 |
| ATM | phosphorylation → up-regulates | TP53BP1 | SIGNOR-197619 |
| p38 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264445 |
| GSK3B | phosphorylation → up-regulates activity | TP53BP1 | SIGNOR-278226 |
| MAPK13 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264449 |
| ATM | phosphorylation → up-regulates | TP53BP1 | SIGNOR-197611 |