| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | TP53BP1 | Ser1678 | ITSEEERsPAKRGRK | phosphorylation down-regulates activity | 30685087 | SIGNOR-264444 |
| CDK1 | TP53BP1 | Ser1678 | ITSEEERsPAKRGRK | phosphorylation down-regulates activity | 30685087 | SIGNOR-264412 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | phosphorylation up-regulates → | TP53BP1 PSer1678 | phosphorylation down-regulates ⊣ | TP53BP1 | 30685087 | SIGNOR-264444 |
| CDK1 | phosphorylation up-regulates → | TP53BP1 PSer1678 | phosphorylation down-regulates ⊣ | TP53BP1 | 30685087 | SIGNOR-264412 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinB/CDK1 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264444 |
| CDK1 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264412 |