| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP4C | TP53BP1 | Thr1609 | LGPYEAVtPLTKAAD | dephosphorylation up-regulates activity | 24703952 | SIGNOR-264450 |
| p38 | TP53BP1 | Thr1609 | LGPYEAVtPLTKAAD | phosphorylation down-regulates activity | 24703952 | SIGNOR-264445 |
| MAPK13 | TP53BP1 | Thr1609 | LGPYEAVtPLTKAAD | phosphorylation down-regulates activity | 24703952 | SIGNOR-264449 |
| MAPK12 | TP53BP1 | Thr1609 | LGPYEAVtPLTKAAD | phosphorylation down-regulates activity | 24703952 | SIGNOR-264448 |
| MAPK11 | TP53BP1 | Thr1609 | LGPYEAVtPLTKAAD | phosphorylation down-regulates activity | 24703952 | SIGNOR-264447 |
| MAPK14 | TP53BP1 | Thr1609 | LGPYEAVtPLTKAAD | phosphorylation down-regulates activity | 24703952 | SIGNOR-264446 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP4C | dephosphorylation down-regulates ⊣ | TP53BP1 PThr1609 | dephosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264450 |
| p38 | phosphorylation up-regulates → | TP53BP1 PThr1609 | phosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264445 |
| MAPK13 | phosphorylation up-regulates → | TP53BP1 PThr1609 | phosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264449 |
| MAPK12 | phosphorylation up-regulates → | TP53BP1 PThr1609 | phosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264448 |
| MAPK11 | phosphorylation up-regulates → | TP53BP1 PThr1609 | phosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264447 |
| MAPK14 | phosphorylation up-regulates → | TP53BP1 PThr1609 | phosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264446 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP4C | dephosphorylation → up-regulates activity | TP53BP1 | SIGNOR-264450 |
| p38 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264445 |
| MAPK13 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264449 |
| MAPK12 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264448 |
| MAPK11 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264447 |
| MAPK14 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264446 |
