| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP4C | TP53BP1 | Ser1618 | LTKAADIsLDNLVEG | dephosphorylation up-regulates activity | 24703952 | SIGNOR-264451 |
| PLK1 | TP53BP1 | Ser1618 | LTKAADIsLDNLVEG | phosphorylation down-regulates activity | 24703952 | SIGNOR-264413 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP4C | dephosphorylation down-regulates ⊣ | TP53BP1 PSer1618 | dephosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264451 |
| PLK1 | phosphorylation up-regulates → | TP53BP1 PSer1618 | phosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264413 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP4C | dephosphorylation → up-regulates activity | TP53BP1 | SIGNOR-264451 |
| PLK1 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264413 |
