| Name | PTPN13 |
| ID | Q12923 |
| Role | phosphatase |
| Enzymatic Domains |
KIND 3-190 PROSITE-ProRule
FERM 572-872 PROSITE-ProRule
PDZ 1 1093-1178 PROSITE-ProRule
PDZ 2 1368-1452 PROSITE-ProRule
PDZ 3 1501-1588 PROSITE-ProRule
PDZ 4 1788-1868 PROSITE-ProRule
PDZ 5 1882-1965 PROSITE-ProRule
Tyrosine-protein phosphatase 2213-2467 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN13 | STK25 | – | dephosphorylation down-regulates activity | 17657516 | SIGNOR-248711 | |
| PTPN13 | ABL1 | Tyr226 | KRNKPTVyGVSPNYD | dephosphorylation down-regulates activity | 28924170 | SIGNOR-277012 |
| PTPN13 | ERBB2 | – | dephosphorylation down-regulates activity | 19734941 | SIGNOR-277087 | |
| PTPN13 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 15611135 | SIGNOR-132551 |
| PTPN13 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 15611135 | SIGNOR-132555 |
| PTPN13 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 15611135 | SIGNOR-132559 |
| PTPN13 | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 15611135 | SIGNOR-132563 |
| PTPN13 | SRC | – | dephosphorylation down-regulates activity | 19307596 | SIGNOR-277125 | |
| PTPN13 | NFKBIA | Tyr42 | DSMKDEEyEQMVKEL | dephosphorylation up-regulates quantity by stabilization | 11106428 | SIGNOR-248712 |
| PTPN13 | IRS1 | – | dephosphorylation down-regulates activity | 17638892 | SIGNOR-277053 | |
| PTPN13 | EFNB1 | – | dephosphorylation up-regulates activity | 23811940 | SIGNOR-277002 | |
| PTPN13 | TRIP6 | Tyr55 | PLPSEQCyQAPGGPE | dephosphorylation down-regulates activity | 17591779 | SIGNOR-248713 |
| PTPN13 | PDCD10 | – | dephosphorylation down-regulates | 17657516 | SIGNOR-157076 | |
| PTPN13 | PDCD10 | – | dephosphorylation down-regulates activity | 17657516 | SIGNOR-248714 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN13 | dephosphorylation down-regulates ⊣ | ABL1 PTyr226 | dephosphorylation up-regulates → | ABL1 | 28924170 | SIGNOR-277012 |
| PTPN13 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 15611135 | SIGNOR-132551 |
| PTPN13 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 15611135 | SIGNOR-132555 |
| PTPN13 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 15611135 | SIGNOR-132559 |
| PTPN13 | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 15611135 | SIGNOR-132563 |
| PTPN13 | dephosphorylation down-regulates ⊣ | NFKBIA PTyr42 | dephosphorylation down-regulates ⊣ | NFKBIA | 11106428 | SIGNOR-248712 |
| PTPN13 | dephosphorylation down-regulates ⊣ | TRIP6 PTyr55 | dephosphorylation up-regulates → | TRIP6 | 17591779 | SIGNOR-248713 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN13 | dephosphorylation → down-regulates activity | STK25 | SIGNOR-248711 |
| PTPN13 | dephosphorylation → down-regulates activity | ABL1 | SIGNOR-277012 |
| PTPN13 | dephosphorylation → down-regulates activity | ERBB2 | SIGNOR-277087 |
| PTPN13 | dephosphorylation down-regulates | INSR | SIGNOR-132551 |
| PTPN13 | dephosphorylation down-regulates | INSR | SIGNOR-132555 |
| PTPN13 | dephosphorylation down-regulates | INSR | SIGNOR-132559 |
| PTPN13 | dephosphorylation down-regulates | INSR | SIGNOR-132563 |
| PTPN13 | dephosphorylation → down-regulates activity | SRC | SIGNOR-277125 |
| PTPN13 | dephosphorylation → up-regulates quantity by stabilization | NFKBIA | SIGNOR-248712 |
| PTPN13 | dephosphorylation → down-regulates activity | IRS1 | SIGNOR-277053 |
| PTPN13 | dephosphorylation → up-regulates activity | EFNB1 | SIGNOR-277002 |
| PTPN13 | dephosphorylation → down-regulates activity | TRIP6 | SIGNOR-248713 |
| PTPN13 | dephosphorylation down-regulates | PDCD10 | SIGNOR-157076 |
| PTPN13 | dephosphorylation → down-regulates activity | PDCD10 | SIGNOR-248714 |