| Name | NFATC3 |
| ID | Q12968 |
| Role | substrate |
| Enzymatic Domains |
RHD 415-596 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK9 | NFATC3 | Ser165 | RESSLSPsPASSISS | phosphorylation down-regulates | 9374467 | SIGNOR-53368 |
| CSNK1A1 | NFATC3 | Thr210 | FTLGSPLtSPGGSPG | phosphorylation down-regulates activity | 9630228 | SIGNOR-109776 |
| CSNK1A1 | NFATC3 | Thr204 | NEAAARFtLGSPLTS | phosphorylation down-regulates activity | 9630228 | SIGNOR-109768 |
| CSNK1A1 | NFATC3 | Ser211 | TLGSPLTsPGGSPGG | phosphorylation down-regulates activity | 9630228 | SIGNOR-109763 |
| CSNK1A1 | NFATC3 | Ser215 | PLTSPGGsPGGCPGE | phosphorylation down-regulates activity | 9630228 | SIGNOR-109781 |
| CSNK1A1 | NFATC3 | Ser207 | AARFTLGsPLTSPGG | phosphorylation down-regulates activity | 9630228 | SIGNOR-109800 |
| MAPK9 | NFATC3 | Ser163 | SYRESSLsPSPASSI | phosphorylation down-regulates | 9374467 | SIGNOR-53364 |
| MAPK8 | NFATC3 | – | phosphorylation down-regulates | 14517246 | SIGNOR-118220 | |
| PPP3CA | NFATC3 | – | dephosphorylation up-regulates | 21880741 | SIGNOR-176376 | |
| Calcineurin | NFATC3 | – | dephosphorylation up-regulates | 21880741 | SIGNOR-252312 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK9 | phosphorylation up-regulates → | NFATC3 PSer165 | phosphorylation down-regulates ⊣ | NFATC3 | 9374467 | SIGNOR-53368 |
| CSNK1A1 | phosphorylation up-regulates → | NFATC3 PThr210 | phosphorylation down-regulates ⊣ | NFATC3 | 9630228 | SIGNOR-109776 |
| CSNK1A1 | phosphorylation up-regulates → | NFATC3 PThr204 | phosphorylation down-regulates ⊣ | NFATC3 | 9630228 | SIGNOR-109768 |
| CSNK1A1 | phosphorylation up-regulates → | NFATC3 PSer211 | phosphorylation down-regulates ⊣ | NFATC3 | 9630228 | SIGNOR-109763 |
| CSNK1A1 | phosphorylation up-regulates → | NFATC3 PSer215 | phosphorylation down-regulates ⊣ | NFATC3 | 9630228 | SIGNOR-109781 |
| CSNK1A1 | phosphorylation up-regulates → | NFATC3 PSer207 | phosphorylation down-regulates ⊣ | NFATC3 | 9630228 | SIGNOR-109800 |
| MAPK9 | phosphorylation up-regulates → | NFATC3 PSer163 | phosphorylation down-regulates ⊣ | NFATC3 | 9374467 | SIGNOR-53364 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK9 | phosphorylation down-regulates | NFATC3 | SIGNOR-53368 |
| CSNK1A1 | phosphorylation → down-regulates activity | NFATC3 | SIGNOR-109776 |
| CSNK1A1 | phosphorylation → down-regulates activity | NFATC3 | SIGNOR-109768 |
| CSNK1A1 | phosphorylation → down-regulates activity | NFATC3 | SIGNOR-109763 |
| CSNK1A1 | phosphorylation → down-regulates activity | NFATC3 | SIGNOR-109781 |
| CSNK1A1 | phosphorylation → down-regulates activity | NFATC3 | SIGNOR-109800 |
| MAPK9 | phosphorylation down-regulates | NFATC3 | SIGNOR-53364 |
| MAPK8 | phosphorylation down-regulates | NFATC3 | SIGNOR-118220 |
| PPP3CA | dephosphorylation → up-regulates | NFATC3 | SIGNOR-176376 |
| Calcineurin | dephosphorylation → up-regulates | NFATC3 | SIGNOR-252312 |