| Name | PPP1R8 |
| ID | Q12972 |
| Role | substrate |
| Enzymatic Domains |
FHA 49-101 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LYN | PPP1R8 | Tyr264 | FAFSGGLyGGLPPTH | phosphorylation down-regulates activity | 11104670 | SIGNOR-251405 |
| PRKACA | PPP1R8 | Ser199 | PKRKRKNsRVTFSED | phosphorylation down-regulates activity | 9407077 | SIGNOR-250033 |
| CSNK2A2 | PPP1R8 | Thr161 | LGLPEEEtELDNLTE | phosphorylation up-regulates activity | 9407077 | SIGNOR-251024 |
| CSNK2A1 | PPP1R8 | Ser204 | KNSRVTFsEDDEIIN | phosphorylation up-regulates activity | 9407077 | SIGNOR-250930 |
| CSNK2A1 | PPP1R8 | Thr161 | LGLPEEEtELDNLTE | phosphorylation up-regulates activity | 9407077 | SIGNOR-250931 |
| CSNK2A2 | PPP1R8 | Ser204 | KNSRVTFsEDDEIIN | phosphorylation up-regulates activity | 9407077 | SIGNOR-251023 |
| PRKACA | PPP1R8 | Ser178 | TAHNKRIsTLTIEEG | phosphorylation down-regulates activity | 9407077 | SIGNOR-250032 |
| LYN | PPP1R8 | Tyr335 | NEPKKKKyAKEAWPG | phosphorylation down-regulates activity | 11104670 | SIGNOR-251406 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LYN | phosphorylation up-regulates → | PPP1R8 PTyr264 | phosphorylation down-regulates ⊣ | PPP1R8 | 11104670 | SIGNOR-251405 |
| PRKACA | phosphorylation up-regulates → | PPP1R8 PSer199 | phosphorylation down-regulates ⊣ | PPP1R8 | 9407077 | SIGNOR-250033 |
| CSNK2A2 | phosphorylation up-regulates → | PPP1R8 PThr161 | phosphorylation up-regulates → | PPP1R8 | 9407077 | SIGNOR-251024 |
| CSNK2A1 | phosphorylation up-regulates → | PPP1R8 PSer204 | phosphorylation up-regulates → | PPP1R8 | 9407077 | SIGNOR-250930 |
| CSNK2A1 | phosphorylation up-regulates → | PPP1R8 PThr161 | phosphorylation up-regulates → | PPP1R8 | 9407077 | SIGNOR-250931 |
| CSNK2A2 | phosphorylation up-regulates → | PPP1R8 PSer204 | phosphorylation up-regulates → | PPP1R8 | 9407077 | SIGNOR-251023 |
| PRKACA | phosphorylation up-regulates → | PPP1R8 PSer178 | phosphorylation down-regulates ⊣ | PPP1R8 | 9407077 | SIGNOR-250032 |
| LYN | phosphorylation up-regulates → | PPP1R8 PTyr335 | phosphorylation down-regulates ⊣ | PPP1R8 | 11104670 | SIGNOR-251406 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LYN | phosphorylation → down-regulates activity | PPP1R8 | SIGNOR-251405 |
| PRKACA | phosphorylation → down-regulates activity | PPP1R8 | SIGNOR-250033 |
| CSNK2A2 | phosphorylation → up-regulates activity | PPP1R8 | SIGNOR-251024 |
| CSNK2A1 | phosphorylation → up-regulates activity | PPP1R8 | SIGNOR-250930 |
| CSNK2A1 | phosphorylation → up-regulates activity | PPP1R8 | SIGNOR-250931 |
| CSNK2A2 | phosphorylation → up-regulates activity | PPP1R8 | SIGNOR-251023 |
| PRKACA | phosphorylation → down-regulates activity | PPP1R8 | SIGNOR-250032 |
| LYN | phosphorylation → down-regulates activity | PPP1R8 | SIGNOR-251406 |