Entity Details

Name PPP1R8
ID Q12972
Role substrate
Enzymatic Domains
FHA 49-101
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PRKACAPPP1R8Ser178TAHNKRIsTLTIEEGphosphorylation
down-regulates activity		9407077SIGNOR-250032
PRKACAPPP1R8Ser199
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PKRKRKNsRVTFSEDphosphorylation
down-regulates activity		9407077SIGNOR-250033
CSNK2A1PPP1R8Thr161LGLPEEEtELDNLTEphosphorylation
up-regulates activity		9407077SIGNOR-250931
LYNPPP1R8Tyr335NEPKKKKyAKEAWPGphosphorylation
down-regulates activity		11104670SIGNOR-251406
CSNK2A2PPP1R8Thr161LGLPEEEtELDNLTEphosphorylation
up-regulates activity		9407077SIGNOR-251024
CSNK2A2PPP1R8Ser204
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KNSRVTFsEDDEIINphosphorylation
up-regulates activity		9407077SIGNOR-251023
LYNPPP1R8Tyr264FAFSGGLyGGLPPTHphosphorylation
down-regulates activity		11104670SIGNOR-251405
CSNK2A1PPP1R8Ser204
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KNSRVTFsEDDEIINphosphorylation
up-regulates activity		9407077SIGNOR-250930
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PRKACAphosphorylation
up-regulates
→
PPP1R8
PSer178		phosphorylation
down-regulates
⊣		PPP1R89407077SIGNOR-250032
PRKACAphosphorylation
up-regulates
→
PPP1R8
PSer199		phosphorylation
down-regulates
⊣		PPP1R89407077SIGNOR-250033
CSNK2A1phosphorylation
up-regulates
→
PPP1R8
PThr161		phosphorylation
up-regulates
→		PPP1R89407077SIGNOR-250931
LYNphosphorylation
up-regulates
→
PPP1R8
PTyr335		phosphorylation
down-regulates
⊣		PPP1R811104670SIGNOR-251406
CSNK2A2phosphorylation
up-regulates
→
PPP1R8
PThr161		phosphorylation
up-regulates
→		PPP1R89407077SIGNOR-251024
CSNK2A2phosphorylation
up-regulates
→
PPP1R8
PSer204		phosphorylation
up-regulates
→		PPP1R89407077SIGNOR-251023
LYNphosphorylation
up-regulates
→
PPP1R8
PTyr264		phosphorylation
down-regulates
⊣		PPP1R811104670SIGNOR-251405
CSNK2A1phosphorylation
up-regulates
→
PPP1R8
PSer204		phosphorylation
up-regulates
→		PPP1R89407077SIGNOR-250930
Regulator Mechanism/Effect Target SIGNOR-ID
PRKACAphosphorylation
→
down-regulates activity 		PPP1R8SIGNOR-250032
PRKACAphosphorylation
→
down-regulates activity 		PPP1R8SIGNOR-250033
CSNK2A1phosphorylation
→
up-regulates activity 		PPP1R8SIGNOR-250931
LYNphosphorylation
→
down-regulates activity 		PPP1R8SIGNOR-251406
CSNK2A2phosphorylation
→
up-regulates activity 		PPP1R8SIGNOR-251024
CSNK2A2phosphorylation
→
up-regulates activity 		PPP1R8SIGNOR-251023
LYNphosphorylation
→
down-regulates activity 		PPP1R8SIGNOR-251405
CSNK2A1phosphorylation
→
up-regulates activity 		PPP1R8SIGNOR-250930