| Name | TIAM1 |
| ID | Q13009 |
| Role | substrate |
| Enzymatic Domains |
PH 1 434-549 PROSITE-ProRule
RBD 765-832 PROSITE-ProRule
PDZ 845-908 PROSITE-ProRule
DH 1040-1234 PROSITE-ProRule
PH 2 1261-1397 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK1 | TIAM1 | – | phosphorylation down-regulates activity | 20463241 | SIGNOR-279995 | |
| CSNK1A1 | TIAM1 | Ser329 | DVNAGEGsEFADSGI | phosphorylation down-regulates quantity by destabilization | 25124033 | SIGNOR-276673 |
| SRC | TIAM1 | Tyr384 | DAARQGVyENFRREL | phosphorylation down-regulates activity | 19285946 | SIGNOR-279763 |
| MEK1/2 | TIAM1 | Ser329 | DVNAGEGsEFADSGI | phosphorylation down-regulates quantity by destabilization | 25124033 | SIGNOR-276674 |
| SRC | TIAM1 | – | phosphorylation up-regulates | 12810717 | SIGNOR-102354 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1A1 | phosphorylation up-regulates → | TIAM1 PSer329 | phosphorylation down-regulates ⊣ | TIAM1 | 25124033 | SIGNOR-276673 |
| SRC | phosphorylation up-regulates → | TIAM1 PTyr384 | phosphorylation down-regulates ⊣ | TIAM1 | 19285946 | SIGNOR-279763 |
| MEK1/2 | phosphorylation up-regulates → | TIAM1 PSer329 | phosphorylation down-regulates ⊣ | TIAM1 | 25124033 | SIGNOR-276674 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GRK1 | phosphorylation → down-regulates activity | TIAM1 | SIGNOR-279995 |
| CSNK1A1 | phosphorylation down-regulates quantity by destabilization | TIAM1 | SIGNOR-276673 |
| SRC | phosphorylation → down-regulates activity | TIAM1 | SIGNOR-279763 |
| MEK1/2 | phosphorylation down-regulates quantity by destabilization | TIAM1 | SIGNOR-276674 |
| SRC | phosphorylation → up-regulates | TIAM1 | SIGNOR-102354 |