| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MEK1/2 | TIAM1 | Ser329 | DVNAGEGsEFADSGI | phosphorylation down-regulates quantity by destabilization | 25124033 | SIGNOR-276674 |
| CSNK1A1 | TIAM1 | Ser329 | DVNAGEGsEFADSGI | phosphorylation down-regulates quantity by destabilization | 25124033 | SIGNOR-276673 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MEK1/2 | phosphorylation up-regulates → | TIAM1 PSer329 | phosphorylation down-regulates ⊣ | TIAM1 | 25124033 | SIGNOR-276674 |
| CSNK1A1 | phosphorylation up-regulates → | TIAM1 PSer329 | phosphorylation down-regulates ⊣ | TIAM1 | 25124033 | SIGNOR-276673 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MEK1/2 | phosphorylation![]() down-regulates quantity by destabilization | TIAM1 | SIGNOR-276674 |
| CSNK1A1 | phosphorylation![]() down-regulates quantity by destabilization | TIAM1 | SIGNOR-276673 |