| Name | STK4 |
| ID | Q13043 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 30-281 PROSITE-ProRule
SARAH 433-480 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK4 | STK4 | Thr183 | DTMAKRNtVIGTPFW | phosphorylation up-regulates activity | 12223493 | SIGNOR-247577 |
| STK4 | AR | – | phosphorylation down-regulates activity | 21512132 | SIGNOR-280143 | |
| STK4 | PRKCA | Thr228 | PQWNESFtFKLKPSD | phosphorylation up-regulates activity | 26414765 | SIGNOR-280147 |
| STK4 | STK4 | Ser327 | SEEDEMDsGTMVRAV | phosphorylation up-regulates activity | 12223493 | SIGNOR-247569 |
| STK4 | MOB1B | Thr35 | LLKHAEAtLGSGNLR | phosphorylation up-regulates | 21808241 | SIGNOR-175841 |
| STK4 | TNNI3 | Thr51 | SRKLQLKtLLLQIAK | phosphorylation unknown | 18986304 | SIGNOR-182061 |
| STK4 | LAT | – | phosphorylation up-regulates activity | 26456820 | SIGNOR-279661 | |
| STK4 | FOXO4 | – | phosphorylation up-regulates | 18394876 | SIGNOR-178193 | |
| STK4 | LATS2 | Ser872 | HQRCLAHsLVGTPNY | phosphorylation up-regulates | 21808241 | SIGNOR-175821 |
| STK4 | PRKCA | Ser226 | LNPQWNEsFTFKLKP | phosphorylation up-regulates activity | 26414765 | SIGNOR-280146 |
| STK4 | IRF3 | Thr253 | PDPGMSLtDRGVMSY | phosphorylation up-regulates activity | 32174922 | SIGNOR-280144 |
| STK4 | LATS1 | Thr1079 | EHAFYEFtFRRFFDD | phosphorylation up-regulates | 15688006 | SIGNOR-133555 |
| STK4 | IRF3 | Thr75 | RDKPDLPtWKRNFRS | phosphorylation up-regulates activity | 32174922 | SIGNOR-280145 |
| STK4 | BECN1 | Thr108 | GEASDGGtMENLSRR | phosphorylation up-regulates activity | 24141421 | SIGNOR-278502 |
| STK4 | SAFB | – | phosphorylation down-regulates activity | 23893242 | SIGNOR-279296 | |
| STK4 | PRDX1 | Thr90 | CHLAWVNtPKKQGGL | phosphorylation down-regulates activity | 23386615 | SIGNOR-276487 |
| STK4 | MOB1B | Thr12 | FGSRSSKtFKPKKNI | phosphorylation up-regulates | 23431053 | SIGNOR-201314 |
| STK4 | GAPDH | – | phosphorylation up-regulates activity | 23527007 | SIGNOR-279295 | |
| STK4 | MOB1A | Thr12 | FSSRSSKtFKPKKNI | phosphorylation up-regulates | 23431053 | SIGNOR-201306 |
| STK4 | MOB1A | Thr35 | LLKHAEAtLGSGNLR | phosphorylation up-regulates | 21808241 | SIGNOR-175833 |
| STK4 | PDX1 | Thr11 | EEQYYAAtQLYKDPC | phosphorylation down-regulates activity | 24633305 | SIGNOR-278303 |
| STK4 | ABL1 | Thr735 | DTEWRSVtLPRDLQS | phosphorylation down-regulates | 18794806 | SIGNOR-181060 |
| STK4 | FOXO3 | Ser209 | SSAGWKNsIRHNLSL | phosphorylation up-regulates | 22898666 | SIGNOR-191851 |
| STK4 | STK38 | Thr444 | DWVFINYtYKRFEGL | phosphorylation up-regulates activity | 19062280 | SIGNOR-279641 |
| STK4 | PRDX1 | Thr18 | PAPNFKAtAVMPDGQ | phosphorylation down-regulates activity | 23386615 | SIGNOR-276486 |
| STK4 | MOB1B | Thr12 | FGSRSSKtFKPKKNI | phosphorylation up-regulates | 21808241 | SIGNOR-175837 |
| STK4 | FOXO1 | Ser212 | SSAGWKNsIRHNLSL | phosphorylation up-regulates | 18394876 | SIGNOR-178186 |
| STK4 | PRDX1 | Thr183 | GWKPGSDtIKPDVQK | phosphorylation down-regulates activity | 23386615 | SIGNOR-276485 |
| STK4 | MOB1A | Thr35 | LLKHAEAtLGSGNLR | phosphorylation up-regulates | 23431053 | SIGNOR-201310 |
| STK4 | H2BC3 | Ser15 | APAPKKGsKKAITKA | phosphorylation unknown | 21212262 | SIGNOR-171009 |
| STK4 | LATS2 | Ser872 | HQRCLAHsLVGTPNY | phosphorylation up-regulates | 23431053 | SIGNOR-201298 |
| STK4 | LATS1 | Ser909 | HQRCLAHsLVGTPNY | phosphorylation up-regulates | 15688006 | SIGNOR-133551 |
| STK4 | FOXO | Ser212 | SSAGWKNsIRHNLSL | phosphorylation up-regulates | 22898666 | SIGNOR-252998 |
| STK4 | FOXO | – | phosphorylation up-regulates | 18394876 | SIGNOR-253002 | |
| STK4 | TNNI3 | Thr31 | SNYRAYAtEPHAKKK | phosphorylation unknown | 18986304 | SIGNOR-182057 |
| STK4 | FOXO | Ser212 | SSAGWKNsIRHNLSL | phosphorylation up-regulates | 18394876 | SIGNOR-252999 |
| STK4 | LATS1/2 | – | phosphorylation up-regulates | 21808241 | SIGNOR-269859 | |
| STK4 | MOB1B | Thr35 | LLKHAEAtLGSGNLR | phosphorylation up-regulates | 23431053 | SIGNOR-201318 |
| STK4 | Mob1 | – | phosphorylation up-regulates | 21808241 | SIGNOR-269856 | |
| STK4 | LATS2 | Thr1041 | EHAFYEFtFRRFFDD | phosphorylation up-regulates | 23431053 | SIGNOR-201302 |
| STK4 | TNNI3 | Thr143 | RGKFKRPtLRRVRIS | phosphorylation unknown | 18986304 | SIGNOR-182053 |
| STK4 | FOXO | Ser209 | SSAGWKNsIRHNLSL | phosphorylation up-regulates | 22898666 | SIGNOR-253000 |
| STK4 | SIRT1 | – | phosphorylation down-regulates activity | 21212262 | SIGNOR-279574 | |
| STK4 | FOXO1 | Ser212 | SSAGWKNsIRHNLSL | phosphorylation up-regulates | 22898666 | SIGNOR-191847 |
| STK4 | TNNI3 | Thr129 | ITEIADLtQKIFDLR | phosphorylation unknown | 18986304 | SIGNOR-182049 |
| STK4 | H2AX | Ser140 | GKKATQAsQEY | phosphorylation up-regulates activity | 20921231 | SIGNOR-278457 |
| STK4 | LATS2 | Thr1041 | EHAFYEFtFRRFFDD | phosphorylation up-regulates | 21808241 | SIGNOR-175825 |
| STK4 | FOXO | Ser209 | SSAGWKNsIRHNLSL | phosphorylation up-regulates | 18394876 | SIGNOR-253001 |
| STK4 | STK4 | Thr187 | KRNTVIGtPFWMAPE | phosphorylation up-regulates activity | 12223493 | SIGNOR-247581 |
| STK4 | PIK3CA | Thr1061 | KMDWIFHtIKQHALN | phosphorylation down-regulates activity | 38060450 | SIGNOR-277920 |
| STK4 | STK4 | Thr177 | VAGQLTDtMAKRNTV | phosphorylation up-regulates activity | 12223493 | SIGNOR-247573 |
| STK4 | MOB1A | Thr12 | FSSRSSKtFKPKKNI | phosphorylation up-regulates | 21808241 | SIGNOR-175829 |
| STK4 | FOXO3 | Ser209 | SSAGWKNsIRHNLSL | phosphorylation up-regulates | 18394876 | SIGNOR-178190 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK4 | phosphorylation up-regulates → | STK4 PThr183 | phosphorylation up-regulates → | STK4 | 12223493 | SIGNOR-247577 |
| STK4 | phosphorylation up-regulates → | PRKCA PThr228 | phosphorylation up-regulates → | PRKCA | 26414765 | SIGNOR-280147 |
| STK4 | phosphorylation up-regulates → | STK4 PSer327 | phosphorylation up-regulates → | STK4 | 12223493 | SIGNOR-247569 |
| STK4 | phosphorylation up-regulates → | MOB1B PThr35 | phosphorylation up-regulates → | MOB1B | 21808241 | SIGNOR-175841 |
| STK4 | phosphorylation up-regulates → | TNNI3 PThr51 | phosphorylation down-regulates ⊣ | TNNI3 | 18986304 | SIGNOR-182061 |
| STK4 | phosphorylation up-regulates → | LATS2 PSer872 | phosphorylation up-regulates → | LATS2 | 21808241 | SIGNOR-175821 |
| STK4 | phosphorylation up-regulates → | PRKCA PSer226 | phosphorylation up-regulates → | PRKCA | 26414765 | SIGNOR-280146 |
| STK4 | phosphorylation up-regulates → | IRF3 PThr253 | phosphorylation up-regulates → | IRF3 | 32174922 | SIGNOR-280144 |
| STK4 | phosphorylation up-regulates → | LATS1 PThr1079 | phosphorylation up-regulates → | LATS1 | 15688006 | SIGNOR-133555 |
| STK4 | phosphorylation up-regulates → | IRF3 PThr75 | phosphorylation up-regulates → | IRF3 | 32174922 | SIGNOR-280145 |
| STK4 | phosphorylation up-regulates → | BECN1 PThr108 | phosphorylation up-regulates → | BECN1 | 24141421 | SIGNOR-278502 |
| STK4 | phosphorylation up-regulates → | PRDX1 PThr90 | phosphorylation down-regulates ⊣ | PRDX1 | 23386615 | SIGNOR-276487 |
| STK4 | phosphorylation up-regulates → | MOB1B PThr12 | phosphorylation up-regulates → | MOB1B | 23431053 | SIGNOR-201314 |
| STK4 | phosphorylation up-regulates → | MOB1A PThr12 | phosphorylation up-regulates → | MOB1A | 23431053 | SIGNOR-201306 |
| STK4 | phosphorylation up-regulates → | MOB1A PThr35 | phosphorylation up-regulates → | MOB1A | 21808241 | SIGNOR-175833 |
| STK4 | phosphorylation up-regulates → | PDX1 PThr11 | phosphorylation down-regulates ⊣ | PDX1 | 24633305 | SIGNOR-278303 |
| STK4 | phosphorylation up-regulates → | ABL1 PThr735 | phosphorylation down-regulates ⊣ | ABL1 | 18794806 | SIGNOR-181060 |
| STK4 | phosphorylation up-regulates → | FOXO3 PSer209 | phosphorylation up-regulates → | FOXO3 | 22898666 | SIGNOR-191851 |
| STK4 | phosphorylation up-regulates → | STK38 PThr444 | phosphorylation up-regulates → | STK38 | 19062280 | SIGNOR-279641 |
| STK4 | phosphorylation up-regulates → | PRDX1 PThr18 | phosphorylation down-regulates ⊣ | PRDX1 | 23386615 | SIGNOR-276486 |
| STK4 | phosphorylation up-regulates → | MOB1B PThr12 | phosphorylation up-regulates → | MOB1B | 21808241 | SIGNOR-175837 |
| STK4 | phosphorylation up-regulates → | FOXO1 PSer212 | phosphorylation up-regulates → | FOXO1 | 18394876 | SIGNOR-178186 |
| STK4 | phosphorylation up-regulates → | PRDX1 PThr183 | phosphorylation down-regulates ⊣ | PRDX1 | 23386615 | SIGNOR-276485 |
| STK4 | phosphorylation up-regulates → | MOB1A PThr35 | phosphorylation up-regulates → | MOB1A | 23431053 | SIGNOR-201310 |
| STK4 | phosphorylation up-regulates → | H2BC3 PSer15 | phosphorylation down-regulates ⊣ | H2BC3 | 21212262 | SIGNOR-171009 |
| STK4 | phosphorylation up-regulates → | LATS2 PSer872 | phosphorylation up-regulates → | LATS2 | 23431053 | SIGNOR-201298 |
| STK4 | phosphorylation up-regulates → | LATS1 PSer909 | phosphorylation up-regulates → | LATS1 | 15688006 | SIGNOR-133551 |
| STK4 | phosphorylation up-regulates → | FOXO PSer212 | phosphorylation up-regulates → | FOXO | 22898666 | SIGNOR-252998 |
| STK4 | phosphorylation up-regulates → | TNNI3 PThr31 | phosphorylation down-regulates ⊣ | TNNI3 | 18986304 | SIGNOR-182057 |
| STK4 | phosphorylation up-regulates → | FOXO PSer212 | phosphorylation up-regulates → | FOXO | 18394876 | SIGNOR-252999 |
| STK4 | phosphorylation up-regulates → | MOB1B PThr35 | phosphorylation up-regulates → | MOB1B | 23431053 | SIGNOR-201318 |
| STK4 | phosphorylation up-regulates → | LATS2 PThr1041 | phosphorylation up-regulates → | LATS2 | 23431053 | SIGNOR-201302 |
| STK4 | phosphorylation up-regulates → | TNNI3 PThr143 | phosphorylation down-regulates ⊣ | TNNI3 | 18986304 | SIGNOR-182053 |
| STK4 | phosphorylation up-regulates → | FOXO PSer209 | phosphorylation up-regulates → | FOXO | 22898666 | SIGNOR-253000 |
| STK4 | phosphorylation up-regulates → | FOXO1 PSer212 | phosphorylation up-regulates → | FOXO1 | 22898666 | SIGNOR-191847 |
| STK4 | phosphorylation up-regulates → | TNNI3 PThr129 | phosphorylation down-regulates ⊣ | TNNI3 | 18986304 | SIGNOR-182049 |
| STK4 | phosphorylation up-regulates → | H2AX PSer140 | phosphorylation up-regulates → | H2AX | 20921231 | SIGNOR-278457 |
| STK4 | phosphorylation up-regulates → | LATS2 PThr1041 | phosphorylation up-regulates → | LATS2 | 21808241 | SIGNOR-175825 |
| STK4 | phosphorylation up-regulates → | FOXO PSer209 | phosphorylation up-regulates → | FOXO | 18394876 | SIGNOR-253001 |
| STK4 | phosphorylation up-regulates → | STK4 PThr187 | phosphorylation up-regulates → | STK4 | 12223493 | SIGNOR-247581 |
| STK4 | phosphorylation up-regulates → | PIK3CA PThr1061 | phosphorylation down-regulates ⊣ | PIK3CA | 38060450 | SIGNOR-277920 |
| STK4 | phosphorylation up-regulates → | STK4 PThr177 | phosphorylation up-regulates → | STK4 | 12223493 | SIGNOR-247573 |
| STK4 | phosphorylation up-regulates → | MOB1A PThr12 | phosphorylation up-regulates → | MOB1A | 21808241 | SIGNOR-175829 |
| STK4 | phosphorylation up-regulates → | FOXO3 PSer209 | phosphorylation up-regulates → | FOXO3 | 18394876 | SIGNOR-178190 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| STK4 | phosphorylation → up-regulates activity | STK4 | SIGNOR-247577 |
| STK4 | phosphorylation → down-regulates activity | AR | SIGNOR-280143 |
| STK4 | phosphorylation → up-regulates activity | PRKCA | SIGNOR-280147 |
| STK4 | phosphorylation → up-regulates activity | STK4 | SIGNOR-247569 |
| STK4 | phosphorylation → up-regulates | MOB1B | SIGNOR-175841 |
| STK4 | phosphorylation → unknown | TNNI3 | SIGNOR-182061 |
| STK4 | phosphorylation → up-regulates activity | LAT | SIGNOR-279661 |
| STK4 | phosphorylation → up-regulates | FOXO4 | SIGNOR-178193 |
| STK4 | phosphorylation → up-regulates | LATS2 | SIGNOR-175821 |
| STK4 | phosphorylation → up-regulates activity | PRKCA | SIGNOR-280146 |
| STK4 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-280144 |
| STK4 | phosphorylation → up-regulates | LATS1 | SIGNOR-133555 |
| STK4 | phosphorylation → up-regulates activity | IRF3 | SIGNOR-280145 |
| STK4 | phosphorylation → up-regulates activity | BECN1 | SIGNOR-278502 |
| STK4 | phosphorylation → down-regulates activity | SAFB | SIGNOR-279296 |
| STK4 | phosphorylation → down-regulates activity | PRDX1 | SIGNOR-276487 |
| STK4 | phosphorylation → up-regulates | MOB1B | SIGNOR-201314 |
| STK4 | phosphorylation → up-regulates activity | GAPDH | SIGNOR-279295 |
| STK4 | phosphorylation → up-regulates | MOB1A | SIGNOR-201306 |
| STK4 | phosphorylation → up-regulates | MOB1A | SIGNOR-175833 |
| STK4 | phosphorylation → down-regulates activity | PDX1 | SIGNOR-278303 |
| STK4 | phosphorylation down-regulates | ABL1 | SIGNOR-181060 |
| STK4 | phosphorylation → up-regulates | FOXO3 | SIGNOR-191851 |
| STK4 | phosphorylation → up-regulates activity | STK38 | SIGNOR-279641 |
| STK4 | phosphorylation → down-regulates activity | PRDX1 | SIGNOR-276486 |
| STK4 | phosphorylation → up-regulates | MOB1B | SIGNOR-175837 |
| STK4 | phosphorylation → up-regulates | FOXO1 | SIGNOR-178186 |
| STK4 | phosphorylation → down-regulates activity | PRDX1 | SIGNOR-276485 |
| STK4 | phosphorylation → up-regulates | MOB1A | SIGNOR-201310 |
| STK4 | phosphorylation → unknown | H2BC3 | SIGNOR-171009 |
| STK4 | phosphorylation → up-regulates | LATS2 | SIGNOR-201298 |
| STK4 | phosphorylation → up-regulates | LATS1 | SIGNOR-133551 |
| STK4 | phosphorylation → up-regulates | FOXO | SIGNOR-252998 |
| STK4 | phosphorylation → up-regulates | FOXO | SIGNOR-253002 |
| STK4 | phosphorylation → unknown | TNNI3 | SIGNOR-182057 |
| STK4 | phosphorylation → up-regulates | FOXO | SIGNOR-252999 |
| STK4 | phosphorylation → up-regulates | LATS1/2 | SIGNOR-269859 |
| STK4 | phosphorylation → up-regulates | MOB1B | SIGNOR-201318 |
| STK4 | phosphorylation → up-regulates | Mob1 | SIGNOR-269856 |
| STK4 | phosphorylation → up-regulates | LATS2 | SIGNOR-201302 |
| STK4 | phosphorylation → unknown | TNNI3 | SIGNOR-182053 |
| STK4 | phosphorylation → up-regulates | FOXO | SIGNOR-253000 |
| STK4 | phosphorylation → down-regulates activity | SIRT1 | SIGNOR-279574 |
| STK4 | phosphorylation → up-regulates | FOXO1 | SIGNOR-191847 |
| STK4 | phosphorylation → unknown | TNNI3 | SIGNOR-182049 |
| STK4 | phosphorylation → up-regulates activity | H2AX | SIGNOR-278457 |
| STK4 | phosphorylation → up-regulates | LATS2 | SIGNOR-175825 |
| STK4 | phosphorylation → up-regulates | FOXO | SIGNOR-253001 |
| STK4 | phosphorylation → up-regulates activity | STK4 | SIGNOR-247581 |
| STK4 | phosphorylation → down-regulates activity | PIK3CA | SIGNOR-277920 |
| STK4 | phosphorylation → up-regulates activity | STK4 | SIGNOR-247573 |
| STK4 | phosphorylation → up-regulates | MOB1A | SIGNOR-175829 |
| STK4 | phosphorylation → up-regulates | FOXO3 | SIGNOR-178190 |