| Name | STK4 |
| ID | Q13043 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 30-281 PROSITE-ProRule
SARAH 433-480 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | STK4 | Ser82 | SIMQQCDsPHVVKYY | phosphorylation up-regulates | 20028971 | SIGNOR-162327 |
| MST1 | STK4 | Thr183 | DTMAKRNtVIGTPFW | phosphorylation up-regulates | 11805089 | SIGNOR-114289 |
| AKT1 | STK4 | Thr387 | TMKRRDEtMQPAKPS | phosphorylation down-regulates | 23431053 | SIGNOR-252537 |
| AKT1 | STK4 | Thr120 | IIRLRNKtLTEDEIA | phosphorylation down-regulates | 19940129 | SIGNOR-252507 |
| PHLPP1 | STK4 | Thr387 | TMKRRDEtMQPAKPS | dephosphorylation up-regulates activity | 20513427 | SIGNOR-248329 |
| AKT2 | STK4 | Thr387 | TMKRRDEtMQPAKPS | phosphorylation down-regulates | 23431053 | SIGNOR-201125 |
| TAOK3 | STK4 | – | phosphorylation up-regulates | 23431053 | SIGNOR-192762 | |
| FGFR4 | STK4 | – | phosphorylation down-regulates activity | 30903103 | SIGNOR-279714 | |
| AKT | STK4 | Thr387 | TMKRRDEtMQPAKPS | phosphorylation down-regulates | 23431053 | SIGNOR-201121 |
| PPP2CA | STK4 | Thr183 | DTMAKRNtVIGTPFW | dephosphorylation down-regulates | 23431053 | SIGNOR-201270 |
| ABL1 | STK4 | Tyr433 | KIPQDGDyEFLKSWT | phosphorylation up-regulates activity | 21715626 | SIGNOR-260927 |
| AKT3 | STK4 | Thr387 | TMKRRDEtMQPAKPS | phosphorylation down-regulates | 23431053 | SIGNOR-201129 |
| PHLPP2 | STK4 | Thr387 | TMKRRDEtMQPAKPS | dephosphorylation up-regulates activity | 20513427 | SIGNOR-248730 |
| TAOK2 | STK4 | – | phosphorylation up-regulates | 23431053 | SIGNOR-201330 | |
| STK4 | STK4 | Thr187 | KRNTVIGtPFWMAPE | phosphorylation up-regulates activity | 12223493 | SIGNOR-247581 |
| STK4 | STK4 | Thr177 | VAGQLTDtMAKRNTV | phosphorylation up-regulates activity | 12223493 | SIGNOR-247573 |
| TAOK1 | STK4 | – | phosphorylation up-regulates | 23431053 | SIGNOR-201324 | |
| STK4 | STK4 | Thr183 | DTMAKRNtVIGTPFW | phosphorylation up-regulates activity | 12223493 | SIGNOR-247577 |
| AKT | STK4 | Thr120 | IIRLRNKtLTEDEIA | phosphorylation down-regulates | 19940129 | SIGNOR-161829 |
| STK4 | STK4 | Ser327 | SEEDEMDsGTMVRAV | phosphorylation up-regulates activity | 12223493 | SIGNOR-247569 |
| TAOK | STK4 | – | phosphorylation up-regulates | 23431053 | SIGNOR-230710 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | phosphorylation up-regulates → | STK4 PSer82 | phosphorylation up-regulates → | STK4 | 20028971 | SIGNOR-162327 |
| MST1 | phosphorylation up-regulates → | STK4 PThr183 | phosphorylation up-regulates → | STK4 | 11805089 | SIGNOR-114289 |
| AKT1 | phosphorylation up-regulates → | STK4 PThr387 | phosphorylation down-regulates ⊣ | STK4 | 23431053 | SIGNOR-252537 |
| AKT1 | phosphorylation up-regulates → | STK4 PThr120 | phosphorylation down-regulates ⊣ | STK4 | 19940129 | SIGNOR-252507 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | STK4 PThr387 | dephosphorylation down-regulates ⊣ | STK4 | 20513427 | SIGNOR-248329 |
| AKT2 | phosphorylation up-regulates → | STK4 PThr387 | phosphorylation down-regulates ⊣ | STK4 | 23431053 | SIGNOR-201125 |
| AKT | phosphorylation up-regulates → | STK4 PThr387 | phosphorylation down-regulates ⊣ | STK4 | 23431053 | SIGNOR-201121 |
| PPP2CA | dephosphorylation down-regulates ⊣ | STK4 PThr183 | dephosphorylation up-regulates → | STK4 | 23431053 | SIGNOR-201270 |
| ABL1 | phosphorylation up-regulates → | STK4 PTyr433 | phosphorylation up-regulates → | STK4 | 21715626 | SIGNOR-260927 |
| AKT3 | phosphorylation up-regulates → | STK4 PThr387 | phosphorylation down-regulates ⊣ | STK4 | 23431053 | SIGNOR-201129 |
| PHLPP2 | dephosphorylation down-regulates ⊣ | STK4 PThr387 | dephosphorylation down-regulates ⊣ | STK4 | 20513427 | SIGNOR-248730 |
| STK4 | phosphorylation up-regulates → | STK4 PThr187 | phosphorylation up-regulates → | STK4 | 12223493 | SIGNOR-247581 |
| STK4 | phosphorylation up-regulates → | STK4 PThr177 | phosphorylation up-regulates → | STK4 | 12223493 | SIGNOR-247573 |
| STK4 | phosphorylation up-regulates → | STK4 PThr183 | phosphorylation up-regulates → | STK4 | 12223493 | SIGNOR-247577 |
| AKT | phosphorylation up-regulates → | STK4 PThr120 | phosphorylation down-regulates ⊣ | STK4 | 19940129 | SIGNOR-161829 |
| STK4 | phosphorylation up-regulates → | STK4 PSer327 | phosphorylation up-regulates → | STK4 | 12223493 | SIGNOR-247569 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK8 | phosphorylation → up-regulates | STK4 | SIGNOR-162327 |
| MST1 | phosphorylation → up-regulates | STK4 | SIGNOR-114289 |
| AKT1 | phosphorylation down-regulates | STK4 | SIGNOR-252537 |
| AKT1 | phosphorylation down-regulates | STK4 | SIGNOR-252507 |
| PHLPP1 | dephosphorylation → up-regulates activity | STK4 | SIGNOR-248329 |
| AKT2 | phosphorylation down-regulates | STK4 | SIGNOR-201125 |
| TAOK3 | phosphorylation → up-regulates | STK4 | SIGNOR-192762 |
| FGFR4 | phosphorylation → down-regulates activity | STK4 | SIGNOR-279714 |
| AKT | phosphorylation down-regulates | STK4 | SIGNOR-201121 |
| PPP2CA | dephosphorylation down-regulates | STK4 | SIGNOR-201270 |
| ABL1 | phosphorylation → up-regulates activity | STK4 | SIGNOR-260927 |
| AKT3 | phosphorylation down-regulates | STK4 | SIGNOR-201129 |
| PHLPP2 | dephosphorylation → up-regulates activity | STK4 | SIGNOR-248730 |
| TAOK2 | phosphorylation → up-regulates | STK4 | SIGNOR-201330 |
| STK4 | phosphorylation → up-regulates activity | STK4 | SIGNOR-247581 |
| STK4 | phosphorylation → up-regulates activity | STK4 | SIGNOR-247573 |
| TAOK1 | phosphorylation → up-regulates | STK4 | SIGNOR-201324 |
| STK4 | phosphorylation → up-regulates activity | STK4 | SIGNOR-247577 |
| AKT | phosphorylation down-regulates | STK4 | SIGNOR-161829 |
| STK4 | phosphorylation → up-regulates activity | STK4 | SIGNOR-247569 |
| TAOK | phosphorylation → up-regulates | STK4 | SIGNOR-230710 |