| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT3 | STK4 | Thr387 | TMKRRDEtMQPAKPS | phosphorylation down-regulates | 23431053 | SIGNOR-201129 |
| PHLPP2 | STK4 | Thr387 | TMKRRDEtMQPAKPS | dephosphorylation up-regulates activity | 20513427 | SIGNOR-248730 |
| AKT1 | STK4 | Thr387 | TMKRRDEtMQPAKPS | phosphorylation down-regulates | 23431053 | SIGNOR-252537 |
| PHLPP1 | STK4 | Thr387 | TMKRRDEtMQPAKPS | dephosphorylation up-regulates activity | 20513427 | SIGNOR-248329 |
| AKT2 | STK4 | Thr387 | TMKRRDEtMQPAKPS | phosphorylation down-regulates | 23431053 | SIGNOR-201125 |
| AKT | STK4 | Thr387 | TMKRRDEtMQPAKPS | phosphorylation down-regulates | 23431053 | SIGNOR-201121 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT3 | phosphorylation up-regulates → | STK4 PThr387 | phosphorylation down-regulates ⊣ | STK4 | 23431053 | SIGNOR-201129 |
| PHLPP2 | dephosphorylation down-regulates ⊣ | STK4 PThr387 | dephosphorylation down-regulates ⊣ | STK4 | 20513427 | SIGNOR-248730 |
| AKT1 | phosphorylation up-regulates → | STK4 PThr387 | phosphorylation down-regulates ⊣ | STK4 | 23431053 | SIGNOR-252537 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | STK4 PThr387 | dephosphorylation down-regulates ⊣ | STK4 | 20513427 | SIGNOR-248329 |
| AKT2 | phosphorylation up-regulates → | STK4 PThr387 | phosphorylation down-regulates ⊣ | STK4 | 23431053 | SIGNOR-201125 |
| AKT | phosphorylation up-regulates → | STK4 PThr387 | phosphorylation down-regulates ⊣ | STK4 | 23431053 | SIGNOR-201121 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT3 | phosphorylation down-regulates | STK4 | SIGNOR-201129 |
| PHLPP2 | dephosphorylation → up-regulates activity | STK4 | SIGNOR-248730 |
| AKT1 | phosphorylation down-regulates | STK4 | SIGNOR-252537 |
| PHLPP1 | dephosphorylation → up-regulates activity | STK4 | SIGNOR-248329 |
| AKT2 | phosphorylation down-regulates | STK4 | SIGNOR-201125 |
| AKT | phosphorylation down-regulates | STK4 | SIGNOR-201121 |
