| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | STK4 | Thr183 | DTMAKRNtVIGTPFW | dephosphorylation down-regulates | 23431053 | SIGNOR-201270 |
| STK4 | STK4 | Thr183 | DTMAKRNtVIGTPFW | phosphorylation up-regulates activity | 12223493 | SIGNOR-247577 |
| MST1 | STK4 | Thr183 | DTMAKRNtVIGTPFW | phosphorylation up-regulates | 11805089 | SIGNOR-114289 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates ⊣ | STK4 PThr183 | dephosphorylation up-regulates → | STK4 | 23431053 | SIGNOR-201270 |
| STK4 | phosphorylation up-regulates → | STK4 PThr183 | phosphorylation up-regulates → | STK4 | 12223493 | SIGNOR-247577 |
| MST1 | phosphorylation up-regulates → | STK4 PThr183 | phosphorylation up-regulates → | STK4 | 11805089 | SIGNOR-114289 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates | STK4 | SIGNOR-201270 |
| STK4 | phosphorylation → up-regulates activity | STK4 | SIGNOR-247577 |
| MST1 | phosphorylation → up-regulates | STK4 | SIGNOR-114289 |
