| Name | ACACA |
| ID | Q13085 |
| Role | substrate |
| Enzymatic Domains |
Biotin carboxylation 117-618 PROSITE-ProRule
ATP-grasp 275-466 PROSITE-ProRule
Biotinyl-binding 745-819 PROSITE-ProRule
CoA carboxyltransferase N-terminal 1576-1914 PROSITE-ProRule
CoA carboxyltransferase C-terminal 1918-2234 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | ACACA | Ser80 | LHIRSSMsGLHLVKQ | phosphorylation down-regulates activity | 29899443 | SIGNOR-267475 |
| CSNK2A2 | ACACA | Ser29 | GSVSEDNsEDEISNL | phosphorylation unknown | 2900140 | SIGNOR-250973 |
| PPP4C | ACACA | Ser80 | LHIRSSMsGLHLVKQ | dephosphorylation up-regulates activity | 25050742 | SIGNOR-267724 |
| PRKAA1 | ACACA | Ser1201 | IPTLNRMsFSSNLNH | phosphorylation down-regulates activity | 7907095 | SIGNOR-250400 |
| AMPK | ACACA | Ser80 | LHIRSSMsGLHLVKQ | phosphorylation down-regulates | 12015362 | SIGNOR-216655 |
| PRKAA2 | ACACA | Ser80 | LHIRSSMsGLHLVKQ | phosphorylation down-regulates | 12015362 | SIGNOR-87583 |
| PRKACA | ACACA | Ser1201 | IPTLNRMsFSSNLNH | phosphorylation down-regulates activity | 2900138 | SIGNOR-267714 |
| CSNK2A1 | ACACA | Ser29 | GSVSEDNsEDEISNL | phosphorylation unknown | 2900140 | SIGNOR-250823 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | phosphorylation up-regulates → | ACACA PSer80 | phosphorylation down-regulates ⊣ | ACACA | 29899443 | SIGNOR-267475 |
| CSNK2A2 | phosphorylation up-regulates → | ACACA PSer29 | phosphorylation down-regulates ⊣ | ACACA | 2900140 | SIGNOR-250973 |
| PPP4C | dephosphorylation down-regulates ⊣ | ACACA PSer80 | dephosphorylation down-regulates ⊣ | ACACA | 25050742 | SIGNOR-267724 |
| PRKAA1 | phosphorylation up-regulates → | ACACA PSer1201 | phosphorylation down-regulates ⊣ | ACACA | 7907095 | SIGNOR-250400 |
| AMPK | phosphorylation up-regulates → | ACACA PSer80 | phosphorylation down-regulates ⊣ | ACACA | 12015362 | SIGNOR-216655 |
| PRKAA2 | phosphorylation up-regulates → | ACACA PSer80 | phosphorylation down-regulates ⊣ | ACACA | 12015362 | SIGNOR-87583 |
| PRKACA | phosphorylation up-regulates → | ACACA PSer1201 | phosphorylation down-regulates ⊣ | ACACA | 2900138 | SIGNOR-267714 |
| CSNK2A1 | phosphorylation up-regulates → | ACACA PSer29 | phosphorylation down-regulates ⊣ | ACACA | 2900140 | SIGNOR-250823 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AMPK | phosphorylation → down-regulates activity | ACACA | SIGNOR-267475 |
| CSNK2A2 | phosphorylation → unknown | ACACA | SIGNOR-250973 |
| PPP4C | dephosphorylation → up-regulates activity | ACACA | SIGNOR-267724 |
| PRKAA1 | phosphorylation → down-regulates activity | ACACA | SIGNOR-250400 |
| AMPK | phosphorylation down-regulates | ACACA | SIGNOR-216655 |
| PRKAA2 | phosphorylation down-regulates | ACACA | SIGNOR-87583 |
| PRKACA | phosphorylation → down-regulates activity | ACACA | SIGNOR-267714 |
| CSNK2A1 | phosphorylation → unknown | ACACA | SIGNOR-250823 |