| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP4C | ACACA | Ser80 | LHIRSSMsGLHLVKQ | dephosphorylation up-regulates activity | 25050742 | SIGNOR-267724 |
| AMPK | ACACA | Ser80 | LHIRSSMsGLHLVKQ | phosphorylation down-regulates activity | 29899443 | SIGNOR-267475 |
| AMPK | ACACA | Ser80 | LHIRSSMsGLHLVKQ | phosphorylation down-regulates | 12015362 | SIGNOR-216655 |
| PRKAA2 | ACACA | Ser80 | LHIRSSMsGLHLVKQ | phosphorylation down-regulates | 12015362 | SIGNOR-87583 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP4C | dephosphorylation down-regulates ⊣ | ACACA PSer80 | dephosphorylation down-regulates ⊣ | ACACA | 25050742 | SIGNOR-267724 |
| AMPK | phosphorylation up-regulates → | ACACA PSer80 | phosphorylation down-regulates ⊣ | ACACA | 29899443 | SIGNOR-267475 |
| AMPK | phosphorylation up-regulates → | ACACA PSer80 | phosphorylation down-regulates ⊣ | ACACA | 12015362 | SIGNOR-216655 |
| PRKAA2 | phosphorylation up-regulates → | ACACA PSer80 | phosphorylation down-regulates ⊣ | ACACA | 12015362 | SIGNOR-87583 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP4C | dephosphorylation → up-regulates activity | ACACA | SIGNOR-267724 |
| AMPK | phosphorylation → down-regulates activity | ACACA | SIGNOR-267475 |
| AMPK | phosphorylation down-regulates | ACACA | SIGNOR-216655 |
| PRKAA2 | phosphorylation down-regulates | ACACA | SIGNOR-87583 |
