| Name | LCP2 |
| ID | Q13094 |
| Role | substrate |
| Enzymatic Domains |
SAM 15-81
SH2 422-530 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ZAP70 | LCP2 | Tyr145 | PVEDDADyEPPPSND | phosphorylation up-regulates | 8702662 | SIGNOR-42968 |
| MAP4K1 | LCP2 | Ser376 | SSFPQSAsLPPYFSQ | phosphorylation up-regulates | 17353368 | SIGNOR-153613 |
| TXK | LCP2 | Tyr128 | DGEDDGDyESPNEEE | phosphorylation up-regulates activity | 10660534 | SIGNOR-246929 |
| MAP4K1 | LCP2 | Ser376 | PRKQLSESSDDDYDD | phosphorylation down-regulates activity | 17353368 | SIGNOR-274153 |
| ZAP70 | LCP2 | Tyr113 | SSFEEDDyESPNDDQ | phosphorylation up-regulates | 8702662 | SIGNOR-42956 |
| TXK | LCP2 | Tyr113 | SSFEEDDyESPNDDQ | phosphorylation up-regulates | 10660534 | SIGNOR-74844 |
| ZAP70 | LCP2 | Tyr426 | NEEWYVSyITRPEAE | phosphorylation up-regulates | 8702662 | SIGNOR-42976 |
| ZAP70 | LCP2 | Tyr128 | DGEDDGDyESPNEEE | phosphorylation up-regulates | 9047237 | SIGNOR-46859 |
| TXK | LCP2 | Tyr145 | PVEDDADyEPPPSND | phosphorylation up-regulates | 10660534 | SIGNOR-74848 |
| ZAP70 | LCP2 | Tyr113 | SSFEEDDyESPNDDQ | phosphorylation up-regulates | 9047237 | SIGNOR-46855 |
| ZAP70 | LCP2 | Tyr113 | SSFEEDDyESPNDDQ | phosphorylation up-regulates activity | 12817019 | SIGNOR-102507 |
| LCK | LCP2 | Tyr426 | NEEWYVSyITRPEAE | phosphorylation unknown | 8702662 | SIGNOR-251382 |
| TXK | LCP2 | Tyr145 | PVEDDADyEPPPSND | phosphorylation up-regulates | 8892604 | SIGNOR-44669 |
| ZAP70 | LCP2 | Tyr128 | DGEDDGDyESPNEEE | phosphorylation up-regulates activity | 12817019 | SIGNOR-102511 |
| ZAP70 | LCP2 | Tyr145 | PVEDDADyEPPPSND | phosphorylation up-regulates activity | 12817019 | SIGNOR-102515 |
| LCK | LCP2 | Tyr423 | NSLNEEWyVSYITRP | phosphorylation unknown | 8702662 | SIGNOR-251381 |
| ZAP70 | LCP2 | Tyr128 | DGEDDGDyESPNEEE | phosphorylation up-regulates | 8702662 | SIGNOR-42960 |
| FYN | LCP2 | – | phosphorylation down-regulates | 9047237 | SIGNOR-46851 | |
| ZAP70 | LCP2 | Tyr423 | NSLNEEWyVSYITRP | phosphorylation up-regulates | 8702662 | SIGNOR-42972 |
| TXK | LCP2 | Tyr113 | SSFEEDDyESPNDDQ | phosphorylation up-regulates | 8892604 | SIGNOR-44665 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr145 | phosphorylation up-regulates → | LCP2 | 8702662 | SIGNOR-42968 |
| MAP4K1 | phosphorylation up-regulates → | LCP2 PSer376 | phosphorylation up-regulates → | LCP2 | 17353368 | SIGNOR-153613 |
| TXK | phosphorylation up-regulates → | LCP2 PTyr128 | phosphorylation up-regulates → | LCP2 | 10660534 | SIGNOR-246929 |
| MAP4K1 | phosphorylation up-regulates → | LCP2 PSer376 | phosphorylation down-regulates ⊣ | LCP2 | 17353368 | SIGNOR-274153 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr113 | phosphorylation up-regulates → | LCP2 | 8702662 | SIGNOR-42956 |
| TXK | phosphorylation up-regulates → | LCP2 PTyr113 | phosphorylation up-regulates → | LCP2 | 10660534 | SIGNOR-74844 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr426 | phosphorylation up-regulates → | LCP2 | 8702662 | SIGNOR-42976 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr128 | phosphorylation up-regulates → | LCP2 | 9047237 | SIGNOR-46859 |
| TXK | phosphorylation up-regulates → | LCP2 PTyr145 | phosphorylation up-regulates → | LCP2 | 10660534 | SIGNOR-74848 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr113 | phosphorylation up-regulates → | LCP2 | 9047237 | SIGNOR-46855 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr113 | phosphorylation up-regulates → | LCP2 | 12817019 | SIGNOR-102507 |
| LCK | phosphorylation up-regulates → | LCP2 PTyr426 | phosphorylation down-regulates ⊣ | LCP2 | 8702662 | SIGNOR-251382 |
| TXK | phosphorylation up-regulates → | LCP2 PTyr145 | phosphorylation up-regulates → | LCP2 | 8892604 | SIGNOR-44669 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr128 | phosphorylation up-regulates → | LCP2 | 12817019 | SIGNOR-102511 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr145 | phosphorylation up-regulates → | LCP2 | 12817019 | SIGNOR-102515 |
| LCK | phosphorylation up-regulates → | LCP2 PTyr423 | phosphorylation down-regulates ⊣ | LCP2 | 8702662 | SIGNOR-251381 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr128 | phosphorylation up-regulates → | LCP2 | 8702662 | SIGNOR-42960 |
| ZAP70 | phosphorylation up-regulates → | LCP2 PTyr423 | phosphorylation up-regulates → | LCP2 | 8702662 | SIGNOR-42972 |
| TXK | phosphorylation up-regulates → | LCP2 PTyr113 | phosphorylation up-regulates → | LCP2 | 8892604 | SIGNOR-44665 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ZAP70 | phosphorylation → up-regulates | LCP2 | SIGNOR-42968 |
| MAP4K1 | phosphorylation → up-regulates | LCP2 | SIGNOR-153613 |
| TXK | phosphorylation → up-regulates activity | LCP2 | SIGNOR-246929 |
| MAP4K1 | phosphorylation → down-regulates activity | LCP2 | SIGNOR-274153 |
| ZAP70 | phosphorylation → up-regulates | LCP2 | SIGNOR-42956 |
| TXK | phosphorylation → up-regulates | LCP2 | SIGNOR-74844 |
| ZAP70 | phosphorylation → up-regulates | LCP2 | SIGNOR-42976 |
| ZAP70 | phosphorylation → up-regulates | LCP2 | SIGNOR-46859 |
| TXK | phosphorylation → up-regulates | LCP2 | SIGNOR-74848 |
| ZAP70 | phosphorylation → up-regulates | LCP2 | SIGNOR-46855 |
| ZAP70 | phosphorylation → up-regulates activity | LCP2 | SIGNOR-102507 |
| LCK | phosphorylation → unknown | LCP2 | SIGNOR-251382 |
| TXK | phosphorylation → up-regulates | LCP2 | SIGNOR-44669 |
| ZAP70 | phosphorylation → up-regulates activity | LCP2 | SIGNOR-102511 |
| ZAP70 | phosphorylation → up-regulates activity | LCP2 | SIGNOR-102515 |
| LCK | phosphorylation → unknown | LCP2 | SIGNOR-251381 |
| ZAP70 | phosphorylation → up-regulates | LCP2 | SIGNOR-42960 |
| FYN | phosphorylation down-regulates | LCP2 | SIGNOR-46851 |
| ZAP70 | phosphorylation → up-regulates | LCP2 | SIGNOR-42972 |
| TXK | phosphorylation → up-regulates | LCP2 | SIGNOR-44665 |