| Name | DUSP4 |
| ID | Q13115 |
| Role | phosphatase |
| Enzymatic Domains |
Rhodanese 41-159 PROSITE-ProRule
Tyrosine-protein phosphatase 195-336 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DUSP4 | MAPK3 | Thr202 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248715 |
| DUSP4 | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248716 |
| DUSP4 | MAPK1 | – | dephosphorylation down-regulates | 8626452 | SIGNOR-40926 | |
| DUSP4 | MAPK1 | Thr185 | HDHTGFLtEYVATRW | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248717 |
| DUSP4 | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 7535768 | SIGNOR-248718 |
| DUSP4 | MAPK8 | – | dephosphorylation down-regulates | 9020184 | SIGNOR-27756 | |
| DUSP4 | MAPK9 | – | dephosphorylation down-regulates | 8626452 | SIGNOR-40929 | |
| DUSP4 | MAPK14 | – | dephosphorylation down-regulates | 16849326 | SIGNOR-147958 | |
| DUSP4 | ERK1/2 | – | dephosphorylation down-regulates activity | 7535768 | SIGNOR-269933 | |
| DUSP4 | Gbeta | – | dephosphorylation down-regulates activity | 7535768 | SIGNOR-269914 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DUSP4 | dephosphorylation down-regulates ⊣ | MAPK3 PThr202 | dephosphorylation up-regulates → | MAPK3 | 7535768 | SIGNOR-248715 |
| DUSP4 | dephosphorylation down-regulates ⊣ | MAPK3 PTyr204 | dephosphorylation up-regulates → | MAPK3 | 7535768 | SIGNOR-248716 |
| DUSP4 | dephosphorylation down-regulates ⊣ | MAPK1 PThr185 | dephosphorylation up-regulates → | MAPK1 | 7535768 | SIGNOR-248717 |
| DUSP4 | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 7535768 | SIGNOR-248718 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DUSP4 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-248715 |
| DUSP4 | dephosphorylation → down-regulates activity | MAPK3 | SIGNOR-248716 |
| DUSP4 | dephosphorylation down-regulates | MAPK1 | SIGNOR-40926 |
| DUSP4 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248717 |
| DUSP4 | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248718 |
| DUSP4 | dephosphorylation down-regulates | MAPK8 | SIGNOR-27756 |
| DUSP4 | dephosphorylation down-regulates | MAPK9 | SIGNOR-40929 |
| DUSP4 | dephosphorylation down-regulates | MAPK14 | SIGNOR-147958 |
| DUSP4 | dephosphorylation → down-regulates activity | ERK1/2 | SIGNOR-269933 |
| DUSP4 | dephosphorylation → down-regulates activity | Gbeta | SIGNOR-269914 |