| Name | EIF2B5 |
| ID | Q13144 |
| Role | substrate |
| Enzymatic Domains |
W2 543-720 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A2 | EIF2B5 | Ser718 | KEAEEESsEDD | phosphorylation up-regulates activity | 11500362 | SIGNOR-250990 |
| GSK3B | EIF2B5 | Ser540 | MDSEEPDsRGGSPQM | phosphorylation down-regulates activity | 11500362 | SIGNOR-251237 |
| CSNK2A2 | EIF2B5 | Ser717 | LKEAEEEsSEDD | phosphorylation up-regulates activity | 11500362 | SIGNOR-250989 |
| CSNK2A1 | EIF2B5 | Ser717 | LKEAEEEsSEDD | phosphorylation up-regulates activity | 11500362 | SIGNOR-250859 |
| CSNK1A1 | EIF2B5 | Ser469 | DGEFSDDsGADQEKD | phosphorylation unknown | 11500362 | SIGNOR-250788 |
| GSK3B | EIF2B5 | Ser540 | MDSEEPDsRGGSPQM | phosphorylation down-regulates | 18701453 | SIGNOR-180022 |
| CSNK1A1 | EIF2B5 | Ser466 | DEDDGEFsDDSGADQ | phosphorylation unknown | 11500362 | SIGNOR-250787 |
| GSK3B | EIF2B5 | Ser535 | ESEQSMDsEEPDSRG | phosphorylation down-regulates activity | 12133000 | SIGNOR-251236 |
| GSK3A | EIF2B5 | Ser540 | MDSEEPDsRGGSPQM | phosphorylation down-regulates activity | 11500362 | SIGNOR-251215 |
| CSNK2A1 | EIF2B5 | Ser718 | KEAEEESsEDD | phosphorylation up-regulates activity | 11500362 | SIGNOR-250860 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A2 | phosphorylation up-regulates → | EIF2B5 PSer718 | phosphorylation up-regulates → | EIF2B5 | 11500362 | SIGNOR-250990 |
| GSK3B | phosphorylation up-regulates → | EIF2B5 PSer540 | phosphorylation down-regulates ⊣ | EIF2B5 | 11500362 | SIGNOR-251237 |
| CSNK2A2 | phosphorylation up-regulates → | EIF2B5 PSer717 | phosphorylation up-regulates → | EIF2B5 | 11500362 | SIGNOR-250989 |
| CSNK2A1 | phosphorylation up-regulates → | EIF2B5 PSer717 | phosphorylation up-regulates → | EIF2B5 | 11500362 | SIGNOR-250859 |
| CSNK1A1 | phosphorylation up-regulates → | EIF2B5 PSer469 | phosphorylation down-regulates ⊣ | EIF2B5 | 11500362 | SIGNOR-250788 |
| GSK3B | phosphorylation up-regulates → | EIF2B5 PSer540 | phosphorylation down-regulates ⊣ | EIF2B5 | 18701453 | SIGNOR-180022 |
| CSNK1A1 | phosphorylation up-regulates → | EIF2B5 PSer466 | phosphorylation down-regulates ⊣ | EIF2B5 | 11500362 | SIGNOR-250787 |
| GSK3B | phosphorylation up-regulates → | EIF2B5 PSer535 | phosphorylation down-regulates ⊣ | EIF2B5 | 12133000 | SIGNOR-251236 |
| GSK3A | phosphorylation up-regulates → | EIF2B5 PSer540 | phosphorylation down-regulates ⊣ | EIF2B5 | 11500362 | SIGNOR-251215 |
| CSNK2A1 | phosphorylation up-regulates → | EIF2B5 PSer718 | phosphorylation up-regulates → | EIF2B5 | 11500362 | SIGNOR-250860 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A2 | phosphorylation → up-regulates activity | EIF2B5 | SIGNOR-250990 |
| GSK3B | phosphorylation → down-regulates activity | EIF2B5 | SIGNOR-251237 |
| CSNK2A2 | phosphorylation → up-regulates activity | EIF2B5 | SIGNOR-250989 |
| CSNK2A1 | phosphorylation → up-regulates activity | EIF2B5 | SIGNOR-250859 |
| CSNK1A1 | phosphorylation → unknown | EIF2B5 | SIGNOR-250788 |
| GSK3B | phosphorylation down-regulates | EIF2B5 | SIGNOR-180022 |
| CSNK1A1 | phosphorylation → unknown | EIF2B5 | SIGNOR-250787 |
| GSK3B | phosphorylation → down-regulates activity | EIF2B5 | SIGNOR-251236 |
| GSK3A | phosphorylation → down-regulates activity | EIF2B5 | SIGNOR-251215 |
| CSNK2A1 | phosphorylation → up-regulates activity | EIF2B5 | SIGNOR-250860 |