Entity Details

Name GSK3A_Ser540
ID Q13144
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
GSK3BEIF2B5Ser540MDSEEPDsRGGSPQMphosphorylation
down-regulates		18701453SIGNOR-180022
GSK3AEIF2B5Ser540MDSEEPDsRGGSPQMphosphorylation
down-regulates activity		11500362SIGNOR-251215
GSK3BEIF2B5Ser540MDSEEPDsRGGSPQMphosphorylation
down-regulates activity		11500362SIGNOR-251237
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
GSK3Bphosphorylation
up-regulates
→
EIF2B5
PSer540		phosphorylation
down-regulates
⊣		EIF2B518701453SIGNOR-180022
GSK3Aphosphorylation
up-regulates
→
EIF2B5
PSer540		phosphorylation
down-regulates
⊣		EIF2B511500362SIGNOR-251215
GSK3Bphosphorylation
up-regulates
→
EIF2B5
PSer540		phosphorylation
down-regulates
⊣		EIF2B511500362SIGNOR-251237
Regulator Mechanism/Effect Target SIGNOR-ID
GSK3Bphosphorylation
img/direct_inhibition.png
down-regulates 		EIF2B5SIGNOR-180022
GSK3Aphosphorylation
→
down-regulates activity 		EIF2B5SIGNOR-251215
GSK3Bphosphorylation
→
down-regulates activity 		EIF2B5SIGNOR-251237