| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| HIPK3 | FADD | Ser194 | QNRSGAMsPMSWNSD | phosphorylation down-regulates activity | 11034606 | SIGNOR-251272 |
| MAP3K1 | FADD | Ser194 | QNRSGAMsPMSWNSD | phosphorylation down-regulates activity | 15001534 | SIGNOR-123168 |
| PLK1 | FADD | Ser194 | QNRSGAMsPMSWNSD | phosphorylation down-regulates activity | 20890306 | SIGNOR-168204 |
| MAP2K7 | FADD | Ser194 | QNRSGAMsPMSWNSD | phosphorylation down-regulates activity | 15001534 | SIGNOR-123164 |
| CSNK1A1 | FADD | Ser194 | QNRSGAMsPMSWNSD | phosphorylation down-regulates activity | 16061179 | SIGNOR-139307 |
| DUSP26 | FADD | Ser194 | QNRSGAMsPMSWNSD | dephosphorylation down-regulates activity | 24548998 | SIGNOR-204559 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| HIPK3 | phosphorylation up-regulates → | FADD PSer194 | phosphorylation down-regulates ⊣ | FADD | 11034606 | SIGNOR-251272 |
| MAP3K1 | phosphorylation up-regulates → | FADD PSer194 | phosphorylation down-regulates ⊣ | FADD | 15001534 | SIGNOR-123168 |
| PLK1 | phosphorylation up-regulates → | FADD PSer194 | phosphorylation down-regulates ⊣ | FADD | 20890306 | SIGNOR-168204 |
| MAP2K7 | phosphorylation up-regulates → | FADD PSer194 | phosphorylation down-regulates ⊣ | FADD | 15001534 | SIGNOR-123164 |
| CSNK1A1 | phosphorylation up-regulates → | FADD PSer194 | phosphorylation down-regulates ⊣ | FADD | 16061179 | SIGNOR-139307 |
| DUSP26 | dephosphorylation down-regulates ⊣ | FADD PSer194 | dephosphorylation up-regulates → | FADD | 24548998 | SIGNOR-204559 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| HIPK3 | phosphorylation → down-regulates activity | FADD | SIGNOR-251272 |
| MAP3K1 | phosphorylation → down-regulates activity | FADD | SIGNOR-123168 |
| PLK1 | phosphorylation → down-regulates activity | FADD | SIGNOR-168204 |
| MAP2K7 | phosphorylation → down-regulates activity | FADD | SIGNOR-123164 |
| CSNK1A1 | phosphorylation → down-regulates activity | FADD | SIGNOR-139307 |
| DUSP26 | dephosphorylation → down-regulates activity | FADD | SIGNOR-204559 |
