| Name | PAK2 |
| ID | Q13177 |
| Role | kinase |
| Enzymatic Domains |
CRIB 74-87 PROSITE-ProRule
Protein kinase 249-499 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK2 | ABL1 | Ser618 | APTPPKRsSSFREMD | phosphorylation down-regulates | 18161990 | SIGNOR-160215 |
| PAK2 | ABL1 | Ser619 | PTPPKRSsSFREMDG | phosphorylation down-regulates | 18161990 | SIGNOR-160219 |
| PAK2 | MYC | Thr358 | ISNNRKCtSPRSSDT | phosphorylation down-regulates activity | 14749374 | SIGNOR-278489 |
| PAK2 | MYC | Thr400 | T-->E | phosphorylation down-regulates activity | 14749374 | SIGNOR-278490 |
| PAK2 | PRL | Ser207 | LHCLRRDsHKIDNYL | phosphorylation up-regulates | 19555049 | SIGNOR-186211 |
| PAK2 | JUN | Thr2 | tAKMETTF | phosphorylation up-regulates | 21177766 | SIGNOR-170760 |
| PAK2 | JUN | Thr286 | RLEEKVKtLKAQNSE | phosphorylation up-regulates | 21177766 | SIGNOR-170764 |
| PAK2 | JUN | Thr8 | MTAKMETtFYDDALN | phosphorylation up-regulates | 21177766 | SIGNOR-170768 |
| PAK2 | JUN | Thr89 | QSSNGHItTTPTPTQ | phosphorylation up-regulates | 21177766 | SIGNOR-170772 |
| PAK2 | JUN | Thr93 | GHITTTPtPTQFLCP | phosphorylation up-regulates | 21177766 | SIGNOR-170776 |
| PAK2 | VIM | Ser26 | GTASRPSsSRSYVTT | phosphorylation down-regulates activity | 11895474 | SIGNOR-250237 |
| PAK2 | VIM | Ser39 | TTSTRTYsLGSALRP | phosphorylation down-regulates activity | 11895474 | SIGNOR-250239 |
| PAK2 | VIM | Ser66 | GVYATRSsAVRLRSS | phosphorylation down-regulates activity | 11895474 | SIGNOR-250241 |
| PAK2 | VIM | Ser73 | SAVRLRSsVPGVRLL | phosphorylation down-regulates activity | 11895474 | SIGNOR-250243 |
| PAK2 | SYN1 | Ser9 | NYLRRRLsDSNFMAN | phosphorylation unknown | 12237306 | SIGNOR-250236 |
| PAK2 | MYL12A | Ser19 | KRPQRATsNVFAMFD | phosphorylation up-regulates activity | 10047984 | SIGNOR-263020 |
| PAK2 | NF2 | Ser518 | DTDMKRLsMEIEKEK | phosphorylation down-regulates | 18071304 | SIGNOR-159768 |
| PAK2 | SYK | – | phosphorylation up-regulates activity | 14673144 | SIGNOR-279083 | |
| PAK2 | CASP7 | Ser239 | WRSPGRGsWFVQALC | phosphorylation down-regulates | 21555521 | SIGNOR-173655 |
| PAK2 | CASP7 | Ser30 | DAKPDRSsFVPSLFS | phosphorylation down-regulates | 21555521 | SIGNOR-173659 |
| PAK2 | CASP7 | Thr173 | FRGDRCKtLLEKPKL | phosphorylation down-regulates | 21555521 | SIGNOR-173663 |
| PAK2 | RPS6 | Ser235 | IAKRRRLsSLRASTS | phosphorylation unknown | 1985906 | SIGNOR-250231 |
| PAK2 | RPS6 | Ser236 | AKRRRLSsLRASTSK | phosphorylation unknown | 1985906 | SIGNOR-250232 |
| PAK2 | RPS6 | Ser240 | RLSSLRAsTSKSESS | phosphorylation unknown | 1985906 | SIGNOR-250233 |
| PAK2 | RPS6 | Ser242 | SSLRASTsKSESSQK | phosphorylation unknown | 1985906 | SIGNOR-250234 |
| PAK2 | PAK2 | Ser141 | TVKQKYLsFTPPEKD | phosphorylation up-regulates | 16204230 | SIGNOR-140907 |
| PAK2 | PAK2 | – | phosphorylation up-regulates | 16837009 | SIGNOR-147874 | |
| PAK2 | PAK2 | Ser141 | TVKQKYLsFTPPEKD | phosphorylation up-regulates activity | 10075701 | SIGNOR-250228 |
| PAK2 | PAK2 | Ser19 | PAPPVRMsSTIFSTG | phosphorylation up-regulates activity | 10075701 | SIGNOR-250224 |
| PAK2 | PAK2 | Ser192 | PRPDHTKsIYTRSVI | phosphorylation up-regulates activity | 10075701 | SIGNOR-250225 |
| PAK2 | PAK2 | Ser197 | TKSIYTRsVIDPVPA | phosphorylation up-regulates activity | 10075701 | SIGNOR-250226 |
| PAK2 | PAK2 | Ser20 | APPVRMSsTIFSTGG | phosphorylation up-regulates activity | 10075701 | SIGNOR-250227 |
| PAK2 | PAK2 | Ser55 | KPRHKIIsIFSGTEK | phosphorylation up-regulates activity | 10075701 | SIGNOR-250229 |
| PAK2 | PAK2 | Thr402 | PEQSKRStMVGTPYW | phosphorylation up-regulates activity | 10075701 | SIGNOR-250230 |
| PAK2 | MYLK | Ser1208 | MKSRRPKsSLPPVLG | phosphorylation down-regulates activity | 10748018 | SIGNOR-250222 |
| PAK2 | MYLK | Ser1760 | RAIGRLSsMAMISGL | phosphorylation down-regulates activity | 10748018 | SIGNOR-250223 |
| PAK2 | PREX2 | Ser1107 | DTISNRDsYSDCNSN | phosphorylation down-regulates activity | 26438819 | SIGNOR-277182 |
| PAK2 | SORT1 | Ser793 | RFLVHRYsVLQQHAE | phosphorylation down-regulates activity | 31767632 | SIGNOR-273717 |
| PAK2 | MKNK1 | Ser39 | RRGRATDsLPGKFED | phosphorylation down-regulates activity | 15234964 | SIGNOR-250221 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK2 | phosphorylation up-regulates → | ABL1 PSer618 | phosphorylation down-regulates ⊣ | ABL1 | 18161990 | SIGNOR-160215 |
| PAK2 | phosphorylation up-regulates → | ABL1 PSer619 | phosphorylation down-regulates ⊣ | ABL1 | 18161990 | SIGNOR-160219 |
| PAK2 | phosphorylation up-regulates → | MYC PThr358 | phosphorylation down-regulates ⊣ | MYC | 14749374 | SIGNOR-278489 |
| PAK2 | phosphorylation up-regulates → | MYC PThr400 | phosphorylation down-regulates ⊣ | MYC | 14749374 | SIGNOR-278490 |
| PAK2 | phosphorylation up-regulates → | PRL PSer207 | phosphorylation up-regulates → | PRL | 19555049 | SIGNOR-186211 |
| PAK2 | phosphorylation up-regulates → | JUN PThr2 | phosphorylation up-regulates → | JUN | 21177766 | SIGNOR-170760 |
| PAK2 | phosphorylation up-regulates → | JUN PThr286 | phosphorylation up-regulates → | JUN | 21177766 | SIGNOR-170764 |
| PAK2 | phosphorylation up-regulates → | JUN PThr8 | phosphorylation up-regulates → | JUN | 21177766 | SIGNOR-170768 |
| PAK2 | phosphorylation up-regulates → | JUN PThr89 | phosphorylation up-regulates → | JUN | 21177766 | SIGNOR-170772 |
| PAK2 | phosphorylation up-regulates → | JUN PThr93 | phosphorylation up-regulates → | JUN | 21177766 | SIGNOR-170776 |
| PAK2 | phosphorylation up-regulates → | VIM PSer26 | phosphorylation down-regulates ⊣ | VIM | 11895474 | SIGNOR-250237 |
| PAK2 | phosphorylation up-regulates → | VIM PSer39 | phosphorylation down-regulates ⊣ | VIM | 11895474 | SIGNOR-250239 |
| PAK2 | phosphorylation up-regulates → | VIM PSer66 | phosphorylation down-regulates ⊣ | VIM | 11895474 | SIGNOR-250241 |
| PAK2 | phosphorylation up-regulates → | VIM PSer73 | phosphorylation down-regulates ⊣ | VIM | 11895474 | SIGNOR-250243 |
| PAK2 | phosphorylation up-regulates → | SYN1 PSer9 | phosphorylation down-regulates ⊣ | SYN1 | 12237306 | SIGNOR-250236 |
| PAK2 | phosphorylation up-regulates → | MYL12A PSer19 | phosphorylation up-regulates → | MYL12A | 10047984 | SIGNOR-263020 |
| PAK2 | phosphorylation up-regulates → | NF2 PSer518 | phosphorylation down-regulates ⊣ | NF2 | 18071304 | SIGNOR-159768 |
| PAK2 | phosphorylation up-regulates → | CASP7 PSer239 | phosphorylation down-regulates ⊣ | CASP7 | 21555521 | SIGNOR-173655 |
| PAK2 | phosphorylation up-regulates → | CASP7 PSer30 | phosphorylation down-regulates ⊣ | CASP7 | 21555521 | SIGNOR-173659 |
| PAK2 | phosphorylation up-regulates → | CASP7 PThr173 | phosphorylation down-regulates ⊣ | CASP7 | 21555521 | SIGNOR-173663 |
| PAK2 | phosphorylation up-regulates → | RPS6 PSer235 | phosphorylation down-regulates ⊣ | RPS6 | 1985906 | SIGNOR-250231 |
| PAK2 | phosphorylation up-regulates → | RPS6 PSer236 | phosphorylation down-regulates ⊣ | RPS6 | 1985906 | SIGNOR-250232 |
| PAK2 | phosphorylation up-regulates → | RPS6 PSer240 | phosphorylation down-regulates ⊣ | RPS6 | 1985906 | SIGNOR-250233 |
| PAK2 | phosphorylation up-regulates → | RPS6 PSer242 | phosphorylation down-regulates ⊣ | RPS6 | 1985906 | SIGNOR-250234 |
| PAK2 | phosphorylation up-regulates → | PAK2 PSer141 | phosphorylation up-regulates → | PAK2 | 16204230 | SIGNOR-140907 |
| PAK2 | phosphorylation up-regulates → | PAK2 PSer141 | phosphorylation up-regulates → | PAK2 | 10075701 | SIGNOR-250228 |
| PAK2 | phosphorylation up-regulates → | PAK2 PSer19 | phosphorylation up-regulates → | PAK2 | 10075701 | SIGNOR-250224 |
| PAK2 | phosphorylation up-regulates → | PAK2 PSer192 | phosphorylation up-regulates → | PAK2 | 10075701 | SIGNOR-250225 |
| PAK2 | phosphorylation up-regulates → | PAK2 PSer197 | phosphorylation up-regulates → | PAK2 | 10075701 | SIGNOR-250226 |
| PAK2 | phosphorylation up-regulates → | PAK2 PSer20 | phosphorylation up-regulates → | PAK2 | 10075701 | SIGNOR-250227 |
| PAK2 | phosphorylation up-regulates → | PAK2 PSer55 | phosphorylation up-regulates → | PAK2 | 10075701 | SIGNOR-250229 |
| PAK2 | phosphorylation up-regulates → | PAK2 PThr402 | phosphorylation up-regulates → | PAK2 | 10075701 | SIGNOR-250230 |
| PAK2 | phosphorylation up-regulates → | MYLK PSer1208 | phosphorylation down-regulates ⊣ | MYLK | 10748018 | SIGNOR-250222 |
| PAK2 | phosphorylation up-regulates → | MYLK PSer1760 | phosphorylation down-regulates ⊣ | MYLK | 10748018 | SIGNOR-250223 |
| PAK2 | phosphorylation up-regulates → | PREX2 PSer1107 | phosphorylation down-regulates ⊣ | PREX2 | 26438819 | SIGNOR-277182 |
| PAK2 | phosphorylation up-regulates → | SORT1 PSer793 | phosphorylation down-regulates ⊣ | SORT1 | 31767632 | SIGNOR-273717 |
| PAK2 | phosphorylation up-regulates → | MKNK1 PSer39 | phosphorylation down-regulates ⊣ | MKNK1 | 15234964 | SIGNOR-250221 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PAK2 | phosphorylation down-regulates | ABL1 | SIGNOR-160215 |
| PAK2 | phosphorylation down-regulates | ABL1 | SIGNOR-160219 |
| PAK2 | phosphorylation → down-regulates activity | MYC | SIGNOR-278489 |
| PAK2 | phosphorylation → down-regulates activity | MYC | SIGNOR-278490 |
| PAK2 | phosphorylation → up-regulates | PRL | SIGNOR-186211 |
| PAK2 | phosphorylation → up-regulates | JUN | SIGNOR-170760 |
| PAK2 | phosphorylation → up-regulates | JUN | SIGNOR-170764 |
| PAK2 | phosphorylation → up-regulates | JUN | SIGNOR-170768 |
| PAK2 | phosphorylation → up-regulates | JUN | SIGNOR-170772 |
| PAK2 | phosphorylation → up-regulates | JUN | SIGNOR-170776 |
| PAK2 | phosphorylation → down-regulates activity | VIM | SIGNOR-250237 |
| PAK2 | phosphorylation → down-regulates activity | VIM | SIGNOR-250239 |
| PAK2 | phosphorylation → down-regulates activity | VIM | SIGNOR-250241 |
| PAK2 | phosphorylation → down-regulates activity | VIM | SIGNOR-250243 |
| PAK2 | phosphorylation → unknown | SYN1 | SIGNOR-250236 |
| PAK2 | phosphorylation → up-regulates activity | MYL12A | SIGNOR-263020 |
| PAK2 | phosphorylation down-regulates | NF2 | SIGNOR-159768 |
| PAK2 | phosphorylation → up-regulates activity | SYK | SIGNOR-279083 |
| PAK2 | phosphorylation down-regulates | CASP7 | SIGNOR-173655 |
| PAK2 | phosphorylation down-regulates | CASP7 | SIGNOR-173659 |
| PAK2 | phosphorylation down-regulates | CASP7 | SIGNOR-173663 |
| PAK2 | phosphorylation → unknown | RPS6 | SIGNOR-250231 |
| PAK2 | phosphorylation → unknown | RPS6 | SIGNOR-250232 |
| PAK2 | phosphorylation → unknown | RPS6 | SIGNOR-250233 |
| PAK2 | phosphorylation → unknown | RPS6 | SIGNOR-250234 |
| PAK2 | phosphorylation → up-regulates | PAK2 | SIGNOR-140907 |
| PAK2 | phosphorylation → up-regulates | PAK2 | SIGNOR-147874 |
| PAK2 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-250228 |
| PAK2 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-250224 |
| PAK2 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-250225 |
| PAK2 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-250226 |
| PAK2 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-250227 |
| PAK2 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-250229 |
| PAK2 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-250230 |
| PAK2 | phosphorylation → down-regulates activity | MYLK | SIGNOR-250222 |
| PAK2 | phosphorylation → down-regulates activity | MYLK | SIGNOR-250223 |
| PAK2 | phosphorylation → down-regulates activity | PREX2 | SIGNOR-277182 |
| PAK2 | phosphorylation → down-regulates activity | SORT1 | SIGNOR-273717 |
| PAK2 | phosphorylation → down-regulates activity | MKNK1 | SIGNOR-250221 |