| Name | PAK2 |
| ID | Q13177 |
| Role | substrate |
| Enzymatic Domains |
CRIB 74-87 PROSITE-ProRule
Protein kinase 249-499 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK12 | PAK2 | Thr134 | LKFYDSNtVKQKYLS | phosphorylation up-regulates activity | 32483448 | SIGNOR-273109 |
| PAK2 | PAK2 | – | phosphorylation up-regulates | 16837009 | SIGNOR-147874 | |
| PPM1F | PAK2 | – | dephosphorylation down-regulates | 20016286 | SIGNOR-162149 | |
| PAK2 | PAK2 | Ser55 | KPRHKIIsIFSGTEK | phosphorylation up-regulates activity | 10075701 | SIGNOR-250229 |
| PAK2 | PAK2 | Ser197 | TKSIYTRsVIDPVPA | phosphorylation up-regulates activity | 10075701 | SIGNOR-250226 |
| PAK2 | PAK2 | Ser20 | APPVRMSsTIFSTGG | phosphorylation up-regulates activity | 10075701 | SIGNOR-250227 |
| CyclinK/CDK12 | PAK2 | Thr134 | LKFYDSNtVKQKYLS | phosphorylation up-regulates activity | 32483448 | SIGNOR-273111 |
| SRC | PAK2 | Tyr130 | VLDVLKFyDSNTVKQ | phosphorylation up-regulates | 12215529 | SIGNOR-92460 |
| PAK2 | PAK2 | Ser19 | PAPPVRMsSTIFSTG | phosphorylation up-regulates activity | 10075701 | SIGNOR-250224 |
| CDK12 | PAK2 | Thr169 | TEAPAVVtEEEDDDE | phosphorylation up-regulates activity | 32483448 | SIGNOR-273110 |
| PAK2 | PAK2 | Ser141 | TVKQKYLsFTPPEKD | phosphorylation up-regulates | 16204230 | SIGNOR-140907 |
| CyclinK/CDK12 | PAK2 | Thr169 | TEAPAVVtEEEDDDE | phosphorylation up-regulates activity | 32483448 | SIGNOR-273112 |
| AMPK | PAK2 | Ser20 | APPVRMSsTIFSTGG | phosphorylation unknown | 22137581 | SIGNOR-216612 |
| PAK2 | PAK2 | Ser141 | TVKQKYLsFTPPEKD | phosphorylation up-regulates activity | 10075701 | SIGNOR-250228 |
| PAK2 | PAK2 | Thr402 | PEQSKRStMVGTPYW | phosphorylation up-regulates activity | 10075701 | SIGNOR-250230 |
| PRKAA2 | PAK2 | Ser20 | APPVRMSsTIFSTGG | phosphorylation unknown | 22137581 | SIGNOR-195110 |
| PAK2 | PAK2 | Ser192 | PRPDHTKsIYTRSVI | phosphorylation up-regulates activity | 10075701 | SIGNOR-250225 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK12 | phosphorylation up-regulates → | PAK2 PThr134 | phosphorylation up-regulates → | PAK2 | 32483448 | SIGNOR-273109 |
| PAK2 | phosphorylation up-regulates → | PAK2 PSer55 | phosphorylation up-regulates → | PAK2 | 10075701 | SIGNOR-250229 |
| PAK2 | phosphorylation up-regulates → | PAK2 PSer197 | phosphorylation up-regulates → | PAK2 | 10075701 | SIGNOR-250226 |
| PAK2 | phosphorylation up-regulates → | PAK2 PSer20 | phosphorylation up-regulates → | PAK2 | 10075701 | SIGNOR-250227 |
| CyclinK/CDK12 | phosphorylation up-regulates → | PAK2 PThr134 | phosphorylation up-regulates → | PAK2 | 32483448 | SIGNOR-273111 |
| SRC | phosphorylation up-regulates → | PAK2 PTyr130 | phosphorylation up-regulates → | PAK2 | 12215529 | SIGNOR-92460 |
| PAK2 | phosphorylation up-regulates → | PAK2 PSer19 | phosphorylation up-regulates → | PAK2 | 10075701 | SIGNOR-250224 |
| CDK12 | phosphorylation up-regulates → | PAK2 PThr169 | phosphorylation up-regulates → | PAK2 | 32483448 | SIGNOR-273110 |
| PAK2 | phosphorylation up-regulates → | PAK2 PSer141 | phosphorylation up-regulates → | PAK2 | 16204230 | SIGNOR-140907 |
| CyclinK/CDK12 | phosphorylation up-regulates → | PAK2 PThr169 | phosphorylation up-regulates → | PAK2 | 32483448 | SIGNOR-273112 |
| AMPK | phosphorylation up-regulates → | PAK2 PSer20 | phosphorylation down-regulates ⊣ | PAK2 | 22137581 | SIGNOR-216612 |
| PAK2 | phosphorylation up-regulates → | PAK2 PSer141 | phosphorylation up-regulates → | PAK2 | 10075701 | SIGNOR-250228 |
| PAK2 | phosphorylation up-regulates → | PAK2 PThr402 | phosphorylation up-regulates → | PAK2 | 10075701 | SIGNOR-250230 |
| PRKAA2 | phosphorylation up-regulates → | PAK2 PSer20 | phosphorylation down-regulates ⊣ | PAK2 | 22137581 | SIGNOR-195110 |
| PAK2 | phosphorylation up-regulates → | PAK2 PSer192 | phosphorylation up-regulates → | PAK2 | 10075701 | SIGNOR-250225 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK12 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-273109 |
| PAK2 | phosphorylation → up-regulates | PAK2 | SIGNOR-147874 |
| PPM1F | dephosphorylation down-regulates | PAK2 | SIGNOR-162149 |
| PAK2 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-250229 |
| PAK2 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-250226 |
| PAK2 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-250227 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-273111 |
| SRC | phosphorylation → up-regulates | PAK2 | SIGNOR-92460 |
| PAK2 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-250224 |
| CDK12 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-273110 |
| PAK2 | phosphorylation → up-regulates | PAK2 | SIGNOR-140907 |
| CyclinK/CDK12 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-273112 |
| AMPK | phosphorylation → unknown | PAK2 | SIGNOR-216612 |
| PAK2 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-250228 |
| PAK2 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-250230 |
| PRKAA2 | phosphorylation → unknown | PAK2 | SIGNOR-195110 |
| PAK2 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-250225 |