| Name | STK3 |
| ID | Q13188 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 27-278 PROSITE-ProRule
SARAH 437-484 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK3 | LATS1 | Ser909 | HQRCLAHsLVGTPNY | phosphorylation up-regulates | 15688006 | SIGNOR-133544 |
| STK3 | LATS1 | Thr1079 | EHAFYEFtFRRFFDD | phosphorylation up-regulates | 15688006 | SIGNOR-132927 |
| STK3 | ABL1 | Thr735 | DTEWRSVtLPRDLQS | phosphorylation down-regulates | 18794806 | SIGNOR-181056 |
| STK3 | PRKCA | Ser226 | LNPQWNEsFTFKLKP | phosphorylation up-regulates activity | 26414765 | SIGNOR-277177 |
| STK3 | PRKCA | Thr228 | PQWNESFtFKLKPSD | phosphorylation up-regulates activity | 26414765 | SIGNOR-277176 |
| STK3 | RCC1 | Ser11 | KRIAKRRsPPADAIP | phosphorylation up-regulates | 19559616 | SIGNOR-263145 |
| STK3 | RCC1 | Ser2 | sPKRIAKR | phosphorylation up-regulates | 19559616 | SIGNOR-263146 |
| STK3 | STAT3 | Thr622 | KEGGVTFtWVEKDIS | phosphorylation down-regulates activity | 35722967 | SIGNOR-277599 |
| STK3 | PIK3CA | Thr1061 | KMDWIFHtIKQHALN | phosphorylation down-regulates activity | 38060450 | SIGNOR-277922 |
| STK3 | NEK2 | Ser438 | EKNYQLKsRQILGMR | phosphorylation up-regulates | 21076410 | SIGNOR-169539 |
| STK3 | STK3 | Thr180 | DTMAKRNtVIGTPFW | phosphorylation up-regulates | 20231902 | SIGNOR-164310 |
| STK3 | MOB1B | Thr12 | FGSRSSKtFKPKKNI | phosphorylation up-regulates | 21808241 | SIGNOR-175813 |
| STK3 | MOB1B | Thr35 | LLKHAEAtLGSGNLR | phosphorylation up-regulates | 21808241 | SIGNOR-175817 |
| STK3 | MOB1B | Thr12 | FGSRSSKtFKPKKNI | phosphorylation up-regulates | 23431053 | SIGNOR-201290 |
| STK3 | MOB1B | Thr35 | LLKHAEAtLGSGNLR | phosphorylation up-regulates | 23431053 | SIGNOR-201294 |
| STK3 | SAV1 | – | phosphorylation up-regulates | 16930133 | SIGNOR-230716 | |
| STK3 | MOB1A | Thr74 | QINMLYGtITEFCTE | phosphorylation up-regulates | 18362890 | SIGNOR-177977 |
| STK3 | MOB1A | Thr12 | FSSRSSKtFKPKKNI | phosphorylation up-regulates | 21808241 | SIGNOR-175805 |
| STK3 | MOB1A | Thr35 | LLKHAEAtLGSGNLR | phosphorylation up-regulates | 21808241 | SIGNOR-175809 |
| STK3 | MOB1A | Thr12 | FSSRSSKtFKPKKNI | phosphorylation up-regulates | 23431053 | SIGNOR-201282 |
| STK3 | MOB1A | Thr35 | LLKHAEAtLGSGNLR | phosphorylation up-regulates | 23431053 | SIGNOR-201286 |
| STK3 | LATS2 | Ser872 | HQRCLAHsLVGTPNY | phosphorylation up-regulates | 21808241 | SIGNOR-175797 |
| STK3 | LATS2 | Thr1041 | EHAFYEFtFRRFFDD | phosphorylation up-regulates | 21808241 | SIGNOR-175801 |
| STK3 | LATS2 | Ser872 | HQRCLAHsLVGTPNY | phosphorylation up-regulates | 23431053 | SIGNOR-201274 |
| STK3 | LATS2 | Thr1041 | EHAFYEFtFRRFFDD | phosphorylation up-regulates | 23431053 | SIGNOR-201278 |
| STK3 | Mob1 | – | phosphorylation up-regulates | 21808241 | SIGNOR-269855 | |
| STK3 | LATS1/2 | – | phosphorylation up-regulates | 21808241 | SIGNOR-269862 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK3 | phosphorylation up-regulates → | LATS1 PSer909 | phosphorylation up-regulates → | LATS1 | 15688006 | SIGNOR-133544 |
| STK3 | phosphorylation up-regulates → | LATS1 PThr1079 | phosphorylation up-regulates → | LATS1 | 15688006 | SIGNOR-132927 |
| STK3 | phosphorylation up-regulates → | ABL1 PThr735 | phosphorylation down-regulates ⊣ | ABL1 | 18794806 | SIGNOR-181056 |
| STK3 | phosphorylation up-regulates → | PRKCA PSer226 | phosphorylation up-regulates → | PRKCA | 26414765 | SIGNOR-277177 |
| STK3 | phosphorylation up-regulates → | PRKCA PThr228 | phosphorylation up-regulates → | PRKCA | 26414765 | SIGNOR-277176 |
| STK3 | phosphorylation up-regulates → | RCC1 PSer11 | phosphorylation up-regulates → | RCC1 | 19559616 | SIGNOR-263145 |
| STK3 | phosphorylation up-regulates → | RCC1 PSer2 | phosphorylation up-regulates → | RCC1 | 19559616 | SIGNOR-263146 |
| STK3 | phosphorylation up-regulates → | STAT3 PThr622 | phosphorylation down-regulates ⊣ | STAT3 | 35722967 | SIGNOR-277599 |
| STK3 | phosphorylation up-regulates → | PIK3CA PThr1061 | phosphorylation down-regulates ⊣ | PIK3CA | 38060450 | SIGNOR-277922 |
| STK3 | phosphorylation up-regulates → | NEK2 PSer438 | phosphorylation up-regulates → | NEK2 | 21076410 | SIGNOR-169539 |
| STK3 | phosphorylation up-regulates → | STK3 PThr180 | phosphorylation up-regulates → | STK3 | 20231902 | SIGNOR-164310 |
| STK3 | phosphorylation up-regulates → | MOB1B PThr12 | phosphorylation up-regulates → | MOB1B | 21808241 | SIGNOR-175813 |
| STK3 | phosphorylation up-regulates → | MOB1B PThr35 | phosphorylation up-regulates → | MOB1B | 21808241 | SIGNOR-175817 |
| STK3 | phosphorylation up-regulates → | MOB1B PThr12 | phosphorylation up-regulates → | MOB1B | 23431053 | SIGNOR-201290 |
| STK3 | phosphorylation up-regulates → | MOB1B PThr35 | phosphorylation up-regulates → | MOB1B | 23431053 | SIGNOR-201294 |
| STK3 | phosphorylation up-regulates → | MOB1A PThr74 | phosphorylation up-regulates → | MOB1A | 18362890 | SIGNOR-177977 |
| STK3 | phosphorylation up-regulates → | MOB1A PThr12 | phosphorylation up-regulates → | MOB1A | 21808241 | SIGNOR-175805 |
| STK3 | phosphorylation up-regulates → | MOB1A PThr35 | phosphorylation up-regulates → | MOB1A | 21808241 | SIGNOR-175809 |
| STK3 | phosphorylation up-regulates → | MOB1A PThr12 | phosphorylation up-regulates → | MOB1A | 23431053 | SIGNOR-201282 |
| STK3 | phosphorylation up-regulates → | MOB1A PThr35 | phosphorylation up-regulates → | MOB1A | 23431053 | SIGNOR-201286 |
| STK3 | phosphorylation up-regulates → | LATS2 PSer872 | phosphorylation up-regulates → | LATS2 | 21808241 | SIGNOR-175797 |
| STK3 | phosphorylation up-regulates → | LATS2 PThr1041 | phosphorylation up-regulates → | LATS2 | 21808241 | SIGNOR-175801 |
| STK3 | phosphorylation up-regulates → | LATS2 PSer872 | phosphorylation up-regulates → | LATS2 | 23431053 | SIGNOR-201274 |
| STK3 | phosphorylation up-regulates → | LATS2 PThr1041 | phosphorylation up-regulates → | LATS2 | 23431053 | SIGNOR-201278 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| STK3 | phosphorylation → up-regulates | LATS1 | SIGNOR-133544 |
| STK3 | phosphorylation → up-regulates | LATS1 | SIGNOR-132927 |
| STK3 | phosphorylation down-regulates | ABL1 | SIGNOR-181056 |
| STK3 | phosphorylation → up-regulates activity | PRKCA | SIGNOR-277177 |
| STK3 | phosphorylation → up-regulates activity | PRKCA | SIGNOR-277176 |
| STK3 | phosphorylation → up-regulates | RCC1 | SIGNOR-263145 |
| STK3 | phosphorylation → up-regulates | RCC1 | SIGNOR-263146 |
| STK3 | phosphorylation → down-regulates activity | STAT3 | SIGNOR-277599 |
| STK3 | phosphorylation → down-regulates activity | PIK3CA | SIGNOR-277922 |
| STK3 | phosphorylation → up-regulates | NEK2 | SIGNOR-169539 |
| STK3 | phosphorylation → up-regulates | STK3 | SIGNOR-164310 |
| STK3 | phosphorylation → up-regulates | MOB1B | SIGNOR-175813 |
| STK3 | phosphorylation → up-regulates | MOB1B | SIGNOR-175817 |
| STK3 | phosphorylation → up-regulates | MOB1B | SIGNOR-201290 |
| STK3 | phosphorylation → up-regulates | MOB1B | SIGNOR-201294 |
| STK3 | phosphorylation → up-regulates | SAV1 | SIGNOR-230716 |
| STK3 | phosphorylation → up-regulates | MOB1A | SIGNOR-177977 |
| STK3 | phosphorylation → up-regulates | MOB1A | SIGNOR-175805 |
| STK3 | phosphorylation → up-regulates | MOB1A | SIGNOR-175809 |
| STK3 | phosphorylation → up-regulates | MOB1A | SIGNOR-201282 |
| STK3 | phosphorylation → up-regulates | MOB1A | SIGNOR-201286 |
| STK3 | phosphorylation → up-regulates | LATS2 | SIGNOR-175797 |
| STK3 | phosphorylation → up-regulates | LATS2 | SIGNOR-175801 |
| STK3 | phosphorylation → up-regulates | LATS2 | SIGNOR-201274 |
| STK3 | phosphorylation → up-regulates | LATS2 | SIGNOR-201278 |
| STK3 | phosphorylation → up-regulates | Mob1 | SIGNOR-269855 |
| STK3 | phosphorylation → up-regulates | LATS1/2 | SIGNOR-269862 |