| Name | STK3 |
| ID | Q13188 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 27-278 PROSITE-ProRule
SARAH 437-484 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK2 | STK3 | Ser316 | LEEEEENsDEDELDS | phosphorylation up-regulates activity | 23904266 | SIGNOR-278206 |
| AKT | STK3 | Thr117 | IIRLRNKtLIEDEIA | phosphorylation down-regulates | 20086174 | SIGNOR-244345 |
| ABL1 | STK3 | Tyr81 | MQQCDSPyVVKYYGS | phosphorylation up-regulates | 22590567 | SIGNOR-197538 |
| AKT1 | STK3 | Thr384 | GTMKRNAtSPQVQRP | phosphorylation down-regulates | 20086174 | SIGNOR-163537 |
| AKT | STK3 | Thr117 | IIRLRNKtLIEDEIA | phosphorylation down-regulates | 20231902 | SIGNOR-164298 |
| GRK2 | STK3 | Ser18 | LKKLSEDsLTKQPEE | phosphorylation up-regulates activity | 23904266 | SIGNOR-278207 |
| AKT | STK3 | Thr384 | GTMKRNAtSPQVQRP | phosphorylation down-regulates | 20086174 | SIGNOR-244349 |
| AKT1 | STK3 | Thr117 | IIRLRNKtLIEDEIA | phosphorylation down-regulates | 20086174 | SIGNOR-163533 |
| PPP2CA | STK3 | Thr180 | DTMAKRNtVIGTPFW | dephosphorylation down-regulates | 23431053 | SIGNOR-201266 |
| TAOK | STK3 | – | phosphorylation up-regulates | 23431053 | SIGNOR-230713 | |
| AKT2 | STK3 | Thr117 | IIRLRNKtLIEDEIA | phosphorylation down-regulates | 20231902 | SIGNOR-164302 |
| AKT1 | STK3 | Thr117 | IIRLRNKtLIEDEIA | phosphorylation down-regulates | 20231902 | SIGNOR-252509 |
| TAOK3 | STK3 | – | phosphorylation up-regulates | 23431053 | SIGNOR-201333 | |
| TAOK2 | STK3 | – | phosphorylation up-regulates | 23431053 | SIGNOR-201327 | |
| STK3 | STK3 | Thr180 | DTMAKRNtVIGTPFW | phosphorylation up-regulates | 20231902 | SIGNOR-164310 |
| PLK1 | STK3 | Ser15 | KSKLKKLsEDSLTKQ | phosphorylation down-regulates activity | 37739411 | SIGNOR-277904 |
| AKT3 | STK3 | Thr117 | IIRLRNKtLIEDEIA | phosphorylation down-regulates | 20231902 | SIGNOR-164306 |
| TAOK1 | STK3 | – | phosphorylation up-regulates | 23431053 | SIGNOR-201321 | |
| PLK1 | STK3 | – | phosphorylation up-regulates activity | 29250521 | SIGNOR-280071 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK2 | phosphorylation up-regulates → | STK3 PSer316 | phosphorylation up-regulates → | STK3 | 23904266 | SIGNOR-278206 |
| AKT | phosphorylation up-regulates → | STK3 PThr117 | phosphorylation down-regulates ⊣ | STK3 | 20086174 | SIGNOR-244345 |
| ABL1 | phosphorylation up-regulates → | STK3 PTyr81 | phosphorylation up-regulates → | STK3 | 22590567 | SIGNOR-197538 |
| AKT1 | phosphorylation up-regulates → | STK3 PThr384 | phosphorylation down-regulates ⊣ | STK3 | 20086174 | SIGNOR-163537 |
| AKT | phosphorylation up-regulates → | STK3 PThr117 | phosphorylation down-regulates ⊣ | STK3 | 20231902 | SIGNOR-164298 |
| GRK2 | phosphorylation up-regulates → | STK3 PSer18 | phosphorylation up-regulates → | STK3 | 23904266 | SIGNOR-278207 |
| AKT | phosphorylation up-regulates → | STK3 PThr384 | phosphorylation down-regulates ⊣ | STK3 | 20086174 | SIGNOR-244349 |
| AKT1 | phosphorylation up-regulates → | STK3 PThr117 | phosphorylation down-regulates ⊣ | STK3 | 20086174 | SIGNOR-163533 |
| PPP2CA | dephosphorylation down-regulates ⊣ | STK3 PThr180 | dephosphorylation up-regulates → | STK3 | 23431053 | SIGNOR-201266 |
| AKT2 | phosphorylation up-regulates → | STK3 PThr117 | phosphorylation down-regulates ⊣ | STK3 | 20231902 | SIGNOR-164302 |
| AKT1 | phosphorylation up-regulates → | STK3 PThr117 | phosphorylation down-regulates ⊣ | STK3 | 20231902 | SIGNOR-252509 |
| STK3 | phosphorylation up-regulates → | STK3 PThr180 | phosphorylation up-regulates → | STK3 | 20231902 | SIGNOR-164310 |
| PLK1 | phosphorylation up-regulates → | STK3 PSer15 | phosphorylation down-regulates ⊣ | STK3 | 37739411 | SIGNOR-277904 |
| AKT3 | phosphorylation up-regulates → | STK3 PThr117 | phosphorylation down-regulates ⊣ | STK3 | 20231902 | SIGNOR-164306 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GRK2 | phosphorylation → up-regulates activity | STK3 | SIGNOR-278206 |
| AKT | phosphorylation down-regulates | STK3 | SIGNOR-244345 |
| ABL1 | phosphorylation → up-regulates | STK3 | SIGNOR-197538 |
| AKT1 | phosphorylation down-regulates | STK3 | SIGNOR-163537 |
| AKT | phosphorylation down-regulates | STK3 | SIGNOR-164298 |
| GRK2 | phosphorylation → up-regulates activity | STK3 | SIGNOR-278207 |
| AKT | phosphorylation down-regulates | STK3 | SIGNOR-244349 |
| AKT1 | phosphorylation down-regulates | STK3 | SIGNOR-163533 |
| PPP2CA | dephosphorylation down-regulates | STK3 | SIGNOR-201266 |
| TAOK | phosphorylation → up-regulates | STK3 | SIGNOR-230713 |
| AKT2 | phosphorylation down-regulates | STK3 | SIGNOR-164302 |
| AKT1 | phosphorylation down-regulates | STK3 | SIGNOR-252509 |
| TAOK3 | phosphorylation → up-regulates | STK3 | SIGNOR-201333 |
| TAOK2 | phosphorylation → up-regulates | STK3 | SIGNOR-201327 |
| STK3 | phosphorylation → up-regulates | STK3 | SIGNOR-164310 |
| PLK1 | phosphorylation → down-regulates activity | STK3 | SIGNOR-277904 |
| AKT3 | phosphorylation down-regulates | STK3 | SIGNOR-164306 |
| TAOK1 | phosphorylation → up-regulates | STK3 | SIGNOR-201321 |
| PLK1 | phosphorylation → up-regulates activity | STK3 | SIGNOR-280071 |