| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | STK3 | Thr117 | IIRLRNKtLIEDEIA | phosphorylation down-regulates | 20086174 | SIGNOR-163533 |
| AKT2 | STK3 | Thr117 | IIRLRNKtLIEDEIA | phosphorylation down-regulates | 20231902 | SIGNOR-164302 |
| AKT1 | STK3 | Thr117 | IIRLRNKtLIEDEIA | phosphorylation down-regulates | 20231902 | SIGNOR-252509 |
| AKT3 | STK3 | Thr117 | IIRLRNKtLIEDEIA | phosphorylation down-regulates | 20231902 | SIGNOR-164306 |
| AKT | STK3 | Thr117 | IIRLRNKtLIEDEIA | phosphorylation down-regulates | 20086174 | SIGNOR-244345 |
| AKT | STK3 | Thr117 | IIRLRNKtLIEDEIA | phosphorylation down-regulates | 20231902 | SIGNOR-164298 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | STK3 PThr117 | phosphorylation down-regulates ⊣ | STK3 | 20086174 | SIGNOR-163533 |
| AKT2 | phosphorylation up-regulates → | STK3 PThr117 | phosphorylation down-regulates ⊣ | STK3 | 20231902 | SIGNOR-164302 |
| AKT1 | phosphorylation up-regulates → | STK3 PThr117 | phosphorylation down-regulates ⊣ | STK3 | 20231902 | SIGNOR-252509 |
| AKT3 | phosphorylation up-regulates → | STK3 PThr117 | phosphorylation down-regulates ⊣ | STK3 | 20231902 | SIGNOR-164306 |
| AKT | phosphorylation up-regulates → | STK3 PThr117 | phosphorylation down-regulates ⊣ | STK3 | 20086174 | SIGNOR-244345 |
| AKT | phosphorylation up-regulates → | STK3 PThr117 | phosphorylation down-regulates ⊣ | STK3 | 20231902 | SIGNOR-164298 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation![]() down-regulates | STK3 | SIGNOR-163533 |
| AKT2 | phosphorylation![]() down-regulates | STK3 | SIGNOR-164302 |
| AKT1 | phosphorylation![]() down-regulates | STK3 | SIGNOR-252509 |
| AKT3 | phosphorylation![]() down-regulates | STK3 | SIGNOR-164306 |
| AKT | phosphorylation![]() down-regulates | STK3 | SIGNOR-244345 |
| AKT | phosphorylation![]() down-regulates | STK3 | SIGNOR-164298 |