| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN5 | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | dephosphorylation down-regulates activity | 19625523 | SIGNOR-276991 |
| PTEN | GRIN2B | – | dephosphorylation down-regulates activity | 33348808 | SIGNOR-277165 | |
| PRKCB | GRIN2B | Ser1303 | NKLRRQHsYDTFVDL | phosphorylation up-regulates activity | 11306676 | SIGNOR-249084 |
| FYN | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | phosphorylation unknown | 11024032 | SIGNOR-251175 |
| FYN | GRIN2B | Tyr1070 | ISTHTVTyGNIEGNA | phosphorylation unknown | 11024032 | SIGNOR-251170 |
| PRKCG | GRIN2B | Ser1323 | ALAPRSVsLKDKGRF | phosphorylation up-regulates activity | 11306676 | SIGNOR-249088 |
| PRKCA | GRIN2B | Ser1303 | NKLRRQHsYDTFVDL | phosphorylation up-regulates activity | 11306676 | SIGNOR-249083 |
| PTPN5 | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | dephosphorylation down-regulates activity | 20427654 | SIGNOR-265744 |
| PTPRG | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254702 |
| CDK5 | GRIN2B | Ser1116 | YRRRPPRsPDHKRYF | phosphorylation down-regulates quantity | 24607229 | SIGNOR-278265 |
| DAPK1 | GRIN2B | Ser1303 | NKLRRQHsYDTFVDL | phosphorylation up-regulates activity | 20141836 | SIGNOR-278397 |
| PRKCG | GRIN2B | Ser1303 | NKLRRQHsYDTFVDL | phosphorylation up-regulates activity | 11306676 | SIGNOR-249085 |
| PRKCA | GRIN2B | Ser1323 | ALAPRSVsLKDKGRF | phosphorylation up-regulates activity | 11306676 | SIGNOR-249086 |
| PTPN11 | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | dephosphorylation down-regulates activity | 32140036 | SIGNOR-276950 |
| PKA | GRIN2B | Ser1166 | SDDFKRDsVSGGGPC | phosphorylation up-regulates activity | 24431445 | SIGNOR-276617 |
| SRC | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | phosphorylation up-regulates activity | 11483655 | SIGNOR-247180 |
| CSNK2A1 | GRIN2B | Ser1479 | HVYEKLSsIESDV | phosphorylation down-regulates | 15537897 | SIGNOR-130336 |
| CAMK2A | GRIN2B | Ser1303 | NKLRRQHsYDTFVDL | phosphorylation up-regulates activity | 8940188 | SIGNOR-250630 |
| CAMK2B | GRIN2B | Ser1303 | NKLRRQHsYDTFVDL | phosphorylation up-regulates activity | 8940188 | SIGNOR-250688 |
| PRKCB | GRIN2B | Ser1323 | ALAPRSVsLKDKGRF | phosphorylation up-regulates activity | 11306676 | SIGNOR-249087 |
| FYN | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | phosphorylation unknown | 11483655 | SIGNOR-249338 |
| FYN | GRIN2B | Tyr1336 | RFMDGSPyAHMFEMS | phosphorylation unknown | 11024032 | SIGNOR-251173 |
| FYN | GRIN2B | Tyr1109 | FDEIELAyRRRPPRS | phosphorylation unknown | 11024032 | SIGNOR-251171 |
| FYN | GRIN2B | Tyr1252 | CKKAGNLyDISEDNS | phosphorylation unknown | 11024032 | SIGNOR-251172 |
| FYN | GRIN2B | Tyr932 | IRRESSVyDISEHRR | phosphorylation unknown | 11024032 | SIGNOR-251174 |
| FYN | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | phosphorylation up-regulates activity | 11483655 | SIGNOR-247176 |
| EPHB2 | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | phosphorylation up-regulates quantity | 33661095 | SIGNOR-279710 |
| PRKACA | GRIN2B | Ser1166 | SDDFKRDsVSGGGPC | phosphorylation up-regulates activity | 24431445 | SIGNOR-276616 |
| FYN | GRIN2B | Tyr1039 | HSQLSDLyGKFSFKS | phosphorylation unknown | 11024032 | SIGNOR-251169 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN5 | dephosphorylation down-regulates ⊣ | GRIN2B PTyr1474 | dephosphorylation up-regulates → | GRIN2B | 19625523 | SIGNOR-276991 |
| PRKCB | phosphorylation up-regulates → | GRIN2B PSer1303 | phosphorylation up-regulates → | GRIN2B | 11306676 | SIGNOR-249084 |
| FYN | phosphorylation up-regulates → | GRIN2B PTyr1474 | phosphorylation down-regulates ⊣ | GRIN2B | 11024032 | SIGNOR-251175 |
| FYN | phosphorylation up-regulates → | GRIN2B PTyr1070 | phosphorylation down-regulates ⊣ | GRIN2B | 11024032 | SIGNOR-251170 |
| PRKCG | phosphorylation up-regulates → | GRIN2B PSer1323 | phosphorylation up-regulates → | GRIN2B | 11306676 | SIGNOR-249088 |
| PRKCA | phosphorylation up-regulates → | GRIN2B PSer1303 | phosphorylation up-regulates → | GRIN2B | 11306676 | SIGNOR-249083 |
| PTPN5 | dephosphorylation down-regulates ⊣ | GRIN2B PTyr1474 | dephosphorylation up-regulates → | GRIN2B | 20427654 | SIGNOR-265744 |
| PTPRG | dephosphorylation down-regulates ⊣ | GRIN2B PTyr1474 | dephosphorylation down-regulates ⊣ | GRIN2B | 25624455 | SIGNOR-254702 |
| CDK5 | phosphorylation up-regulates → | GRIN2B PSer1116 | phosphorylation down-regulates ⊣ | GRIN2B | 24607229 | SIGNOR-278265 |
| DAPK1 | phosphorylation up-regulates → | GRIN2B PSer1303 | phosphorylation up-regulates → | GRIN2B | 20141836 | SIGNOR-278397 |
| PRKCG | phosphorylation up-regulates → | GRIN2B PSer1303 | phosphorylation up-regulates → | GRIN2B | 11306676 | SIGNOR-249085 |
| PRKCA | phosphorylation up-regulates → | GRIN2B PSer1323 | phosphorylation up-regulates → | GRIN2B | 11306676 | SIGNOR-249086 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GRIN2B PTyr1474 | dephosphorylation up-regulates → | GRIN2B | 32140036 | SIGNOR-276950 |
| PKA | phosphorylation up-regulates → | GRIN2B PSer1166 | phosphorylation up-regulates → | GRIN2B | 24431445 | SIGNOR-276617 |
| SRC | phosphorylation up-regulates → | GRIN2B PTyr1474 | phosphorylation up-regulates → | GRIN2B | 11483655 | SIGNOR-247180 |
| CSNK2A1 | phosphorylation up-regulates → | GRIN2B PSer1479 | phosphorylation down-regulates ⊣ | GRIN2B | 15537897 | SIGNOR-130336 |
| CAMK2A | phosphorylation up-regulates → | GRIN2B PSer1303 | phosphorylation up-regulates → | GRIN2B | 8940188 | SIGNOR-250630 |
| CAMK2B | phosphorylation up-regulates → | GRIN2B PSer1303 | phosphorylation up-regulates → | GRIN2B | 8940188 | SIGNOR-250688 |
| PRKCB | phosphorylation up-regulates → | GRIN2B PSer1323 | phosphorylation up-regulates → | GRIN2B | 11306676 | SIGNOR-249087 |
| FYN | phosphorylation up-regulates → | GRIN2B PTyr1474 | phosphorylation down-regulates ⊣ | GRIN2B | 11483655 | SIGNOR-249338 |
| FYN | phosphorylation up-regulates → | GRIN2B PTyr1336 | phosphorylation down-regulates ⊣ | GRIN2B | 11024032 | SIGNOR-251173 |
| FYN | phosphorylation up-regulates → | GRIN2B PTyr1109 | phosphorylation down-regulates ⊣ | GRIN2B | 11024032 | SIGNOR-251171 |
| FYN | phosphorylation up-regulates → | GRIN2B PTyr1252 | phosphorylation down-regulates ⊣ | GRIN2B | 11024032 | SIGNOR-251172 |
| FYN | phosphorylation up-regulates → | GRIN2B PTyr932 | phosphorylation down-regulates ⊣ | GRIN2B | 11024032 | SIGNOR-251174 |
| FYN | phosphorylation up-regulates → | GRIN2B PTyr1474 | phosphorylation up-regulates → | GRIN2B | 11483655 | SIGNOR-247176 |
| EPHB2 | phosphorylation up-regulates → | GRIN2B PTyr1474 | phosphorylation up-regulates → | GRIN2B | 33661095 | SIGNOR-279710 |
| PRKACA | phosphorylation up-regulates → | GRIN2B PSer1166 | phosphorylation up-regulates → | GRIN2B | 24431445 | SIGNOR-276616 |
| FYN | phosphorylation up-regulates → | GRIN2B PTyr1039 | phosphorylation down-regulates ⊣ | GRIN2B | 11024032 | SIGNOR-251169 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN5 | dephosphorylation → down-regulates activity | GRIN2B | SIGNOR-276991 |
| PTEN | dephosphorylation → down-regulates activity | GRIN2B | SIGNOR-277165 |
| PRKCB | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-249084 |
| FYN | phosphorylation → unknown | GRIN2B | SIGNOR-251175 |
| FYN | phosphorylation → unknown | GRIN2B | SIGNOR-251170 |
| PRKCG | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-249088 |
| PRKCA | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-249083 |
| PTPN5 | dephosphorylation → down-regulates activity | GRIN2B | SIGNOR-265744 |
| PTPRG | dephosphorylation → up-regulates activity | GRIN2B | SIGNOR-254702 |
| CDK5 | phosphorylation → down-regulates quantity | GRIN2B | SIGNOR-278265 |
| DAPK1 | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-278397 |
| PRKCG | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-249085 |
| PRKCA | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-249086 |
| PTPN11 | dephosphorylation → down-regulates activity | GRIN2B | SIGNOR-276950 |
| PKA | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-276617 |
| SRC | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-247180 |
| CSNK2A1 | phosphorylation down-regulates | GRIN2B | SIGNOR-130336 |
| CAMK2A | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-250630 |
| CAMK2B | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-250688 |
| PRKCB | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-249087 |
| FYN | phosphorylation → unknown | GRIN2B | SIGNOR-249338 |
| FYN | phosphorylation → unknown | GRIN2B | SIGNOR-251173 |
| FYN | phosphorylation → unknown | GRIN2B | SIGNOR-251171 |
| FYN | phosphorylation → unknown | GRIN2B | SIGNOR-251172 |
| FYN | phosphorylation → unknown | GRIN2B | SIGNOR-251174 |
| FYN | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-247176 |
| EPHB2 | phosphorylation → up-regulates quantity | GRIN2B | SIGNOR-279710 |
| PRKACA | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-276616 |
| FYN | phosphorylation → unknown | GRIN2B | SIGNOR-251169 |
