| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | phosphorylation up-regulates activity | 11483655 | SIGNOR-247180 |
| FYN | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | phosphorylation unknown | 11483655 | SIGNOR-249338 |
| FYN | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | phosphorylation up-regulates activity | 11483655 | SIGNOR-247176 |
| EPHB2 | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | phosphorylation up-regulates quantity | 33661095 | SIGNOR-279710 |
| PTPN5 | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | dephosphorylation down-regulates activity | 19625523 | SIGNOR-276991 |
| FYN | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | phosphorylation unknown | 11024032 | SIGNOR-251175 |
| PTPN5 | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | dephosphorylation down-regulates activity | 20427654 | SIGNOR-265744 |
| PTPRG | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254702 |
| PTPN11 | GRIN2B | Tyr1474 | GSSNGHVyEKLSSIE | dephosphorylation down-regulates activity | 32140036 | SIGNOR-276950 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | phosphorylation up-regulates → | GRIN2B PTyr1474 | phosphorylation up-regulates → | GRIN2B | 11483655 | SIGNOR-247180 |
| FYN | phosphorylation up-regulates → | GRIN2B PTyr1474 | phosphorylation down-regulates ⊣ | GRIN2B | 11483655 | SIGNOR-249338 |
| FYN | phosphorylation up-regulates → | GRIN2B PTyr1474 | phosphorylation up-regulates → | GRIN2B | 11483655 | SIGNOR-247176 |
| EPHB2 | phosphorylation up-regulates → | GRIN2B PTyr1474 | phosphorylation up-regulates → | GRIN2B | 33661095 | SIGNOR-279710 |
| PTPN5 | dephosphorylation down-regulates ⊣ | GRIN2B PTyr1474 | dephosphorylation up-regulates → | GRIN2B | 19625523 | SIGNOR-276991 |
| FYN | phosphorylation up-regulates → | GRIN2B PTyr1474 | phosphorylation down-regulates ⊣ | GRIN2B | 11024032 | SIGNOR-251175 |
| PTPN5 | dephosphorylation down-regulates ⊣ | GRIN2B PTyr1474 | dephosphorylation up-regulates → | GRIN2B | 20427654 | SIGNOR-265744 |
| PTPRG | dephosphorylation down-regulates ⊣ | GRIN2B PTyr1474 | dephosphorylation down-regulates ⊣ | GRIN2B | 25624455 | SIGNOR-254702 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GRIN2B PTyr1474 | dephosphorylation up-regulates → | GRIN2B | 32140036 | SIGNOR-276950 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SRC | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-247180 |
| FYN | phosphorylation → unknown | GRIN2B | SIGNOR-249338 |
| FYN | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-247176 |
| EPHB2 | phosphorylation → up-regulates quantity | GRIN2B | SIGNOR-279710 |
| PTPN5 | dephosphorylation → down-regulates activity | GRIN2B | SIGNOR-276991 |
| FYN | phosphorylation → unknown | GRIN2B | SIGNOR-251175 |
| PTPN5 | dephosphorylation → down-regulates activity | GRIN2B | SIGNOR-265744 |
| PTPRG | dephosphorylation → up-regulates activity | GRIN2B | SIGNOR-254702 |
| PTPN11 | dephosphorylation → down-regulates activity | GRIN2B | SIGNOR-276950 |
