Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PRKG2	EGFR	Thr430	LEIIRGRtKQHGQFS	phosphorylation down-regulates activity	35226996	SIGNOR-277589
PRKG2	HSPB1	Ser78	PAYSRALsRQLSSGV	phosphorylation down-regulates	19593530	SIGNOR-186796
PRKG2	HSPB1	Ser82	RALSRQLsSGVSEIR	phosphorylation down-regulates	19593530	SIGNOR-186943
PRKG2	HSPB1	Thr143	RCFTRKYtLPPGVDP	phosphorylation down-regulates	19593530	SIGNOR-186947
PRKG2	PDGFRB	Ser712	SDKRRPPsAELYSNA	phosphorylation down-regulates activity	29935031	SIGNOR-277401
PRKG2	PDGFRB	Ser254	WTYPRKEsGRLVEPV	phosphorylation down-regulates activity	35066967	SIGNOR-277577
PRKG2	PTPN6	Ser553	KNAHAKAsRTSSKHK	phosphorylation up-regulates activity	21177494	SIGNOR-276288
PRKG2	PTPN6	Ser556	HAKASRTsSKHKEDV	phosphorylation up-regulates activity	21177494	SIGNOR-276286
PRKG2	PTPN6	Ser557	AKASRTSsKHKEDVY	phosphorylation up-regulates activity	21177494	SIGNOR-276287
PRKG2	CTH	Ser377	SDTLIRLsVGLEDEE	phosphorylation down-regulates activity	25900831	SIGNOR-275800
PRKG2	GRIA1	Ser863	TSTLPRNsGAGASSG	phosphorylation up-regulates activity	18728399	SIGNOR-278427
PRKG2	SOX9	–		phosphorylation down-regulates activity	19543319	SIGNOR-278985
PRKG2	SLC9A3	–		phosphorylation down-regulates activity	25480791	SIGNOR-280096
PRKG2	GSK3B	–		phosphorylation down-regulates activity	18551195	SIGNOR-280095
PRKG2	PLCB3	Ser1105	LDRKRHNsISEAKMR	phosphorylation down-regulates activity	11278298	SIGNOR-249078
PRKG2	PLCB3	Ser26	VETLRRGsKFIKWDE	phosphorylation down-regulates activity	11278298	SIGNOR-249080
PRKG2	PTS	Ser19	AQVSRRIsFSASHRL	phosphorylation up-regulates	10531334	SIGNOR-71751
PRKG2	FOXO1	Ser152	LAGQPRKsSSSRRNA	phosphorylation up-regulates activity	22393355	SIGNOR-279563
PRKG2	FOXO1	Ser319	TFRPRTSsNASTISG	phosphorylation up-regulates activity	22393355	SIGNOR-279564
PRKG2	LASP1	Ser146	MEPERRDsQDGSSYR	phosphorylation unknown	12571245	SIGNOR-249197
PRKG2	HCN2	Ser668	DRIGKKNsILLHKVQ	phosphorylation down-regulates activity	21347269	SIGNOR-263185

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PRKG2	phosphorylation up-regulates →	EGFR PThr430	phosphorylation down-regulates ⊣	EGFR	35226996	SIGNOR-277589
PRKG2	phosphorylation up-regulates →	HSPB1 PSer78	phosphorylation down-regulates ⊣	HSPB1	19593530	SIGNOR-186796
PRKG2	phosphorylation up-regulates →	HSPB1 PSer82	phosphorylation down-regulates ⊣	HSPB1	19593530	SIGNOR-186943
PRKG2	phosphorylation up-regulates →	HSPB1 PThr143	phosphorylation down-regulates ⊣	HSPB1	19593530	SIGNOR-186947
PRKG2	phosphorylation up-regulates →	PDGFRB PSer712	phosphorylation down-regulates ⊣	PDGFRB	29935031	SIGNOR-277401
PRKG2	phosphorylation up-regulates →	PDGFRB PSer254	phosphorylation down-regulates ⊣	PDGFRB	35066967	SIGNOR-277577
PRKG2	phosphorylation up-regulates →	PTPN6 PSer553	phosphorylation up-regulates →	PTPN6	21177494	SIGNOR-276288
PRKG2	phosphorylation up-regulates →	PTPN6 PSer556	phosphorylation up-regulates →	PTPN6	21177494	SIGNOR-276286
PRKG2	phosphorylation up-regulates →	PTPN6 PSer557	phosphorylation up-regulates →	PTPN6	21177494	SIGNOR-276287
PRKG2	phosphorylation up-regulates →	CTH PSer377	phosphorylation down-regulates ⊣	CTH	25900831	SIGNOR-275800
PRKG2	phosphorylation up-regulates →	GRIA1 PSer863	phosphorylation up-regulates →	GRIA1	18728399	SIGNOR-278427
PRKG2	phosphorylation up-regulates →	PLCB3 PSer1105	phosphorylation down-regulates ⊣	PLCB3	11278298	SIGNOR-249078
PRKG2	phosphorylation up-regulates →	PLCB3 PSer26	phosphorylation down-regulates ⊣	PLCB3	11278298	SIGNOR-249080
PRKG2	phosphorylation up-regulates →	PTS PSer19	phosphorylation up-regulates →	PTS	10531334	SIGNOR-71751
PRKG2	phosphorylation up-regulates →	FOXO1 PSer152	phosphorylation up-regulates →	FOXO1	22393355	SIGNOR-279563
PRKG2	phosphorylation up-regulates →	FOXO1 PSer319	phosphorylation up-regulates →	FOXO1	22393355	SIGNOR-279564
PRKG2	phosphorylation up-regulates →	LASP1 PSer146	phosphorylation down-regulates ⊣	LASP1	12571245	SIGNOR-249197
PRKG2	phosphorylation up-regulates →	HCN2 PSer668	phosphorylation down-regulates ⊣	HCN2	21347269	SIGNOR-263185

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PRKG2	phosphorylation → down-regulates activity	EGFR	SIGNOR-277589
PRKG2	phosphorylation down-regulates	HSPB1	SIGNOR-186796
PRKG2	phosphorylation down-regulates	HSPB1	SIGNOR-186943
PRKG2	phosphorylation down-regulates	HSPB1	SIGNOR-186947
PRKG2	phosphorylation → down-regulates activity	PDGFRB	SIGNOR-277401
PRKG2	phosphorylation → down-regulates activity	PDGFRB	SIGNOR-277577
PRKG2	phosphorylation → up-regulates activity	PTPN6	SIGNOR-276288
PRKG2	phosphorylation → up-regulates activity	PTPN6	SIGNOR-276286
PRKG2	phosphorylation → up-regulates activity	PTPN6	SIGNOR-276287
PRKG2	phosphorylation → down-regulates activity	CTH	SIGNOR-275800
PRKG2	phosphorylation → up-regulates activity	GRIA1	SIGNOR-278427
PRKG2	phosphorylation → down-regulates activity	SOX9	SIGNOR-278985
PRKG2	phosphorylation → down-regulates activity	SLC9A3	SIGNOR-280096
PRKG2	phosphorylation → down-regulates activity	GSK3B	SIGNOR-280095
PRKG2	phosphorylation → down-regulates activity	PLCB3	SIGNOR-249078
PRKG2	phosphorylation → down-regulates activity	PLCB3	SIGNOR-249080
PRKG2	phosphorylation → up-regulates	PTS	SIGNOR-71751
PRKG2	phosphorylation → up-regulates activity	FOXO1	SIGNOR-279563
PRKG2	phosphorylation → up-regulates activity	FOXO1	SIGNOR-279564
PRKG2	phosphorylation → unknown	LASP1	SIGNOR-249197
PRKG2	phosphorylation → down-regulates activity	HCN2	SIGNOR-263185