Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
SRC	TRIM28	–		phosphorylation down-regulates activity	23645696	SIGNOR-280137
CHEK1	TRIM28	Ser473 View in OncoXplorer	SGVKRSRsGEGEVSG	phosphorylation up-regulates activity	21851590	SIGNOR-280226
PPP4C	TRIM28	–		dephosphorylation down-regulates activity	22732494	SIGNOR-277163
CHEK2	TRIM28	Ser473 View in OncoXplorer	SGVKRSRsGEGEVSG	phosphorylation down-regulates activity	26158765	SIGNOR-279730
PPP1CA	TRIM28	Ser824 View in OncoXplorer	LPGAGLSsQELSGGP	dephosphorylation up-regulates activity	20424263	SIGNOR-277075
RIPK3	TRIM28	Ser473 View in OncoXplorer	SGVKRSRsGEGEVSG	phosphorylation down-regulates activity	34419074	SIGNOR-279107
PRKCD	TRIM28	Ser473 View in OncoXplorer	SGVKRSRsGEGEVSG	phosphorylation down-regulates	18590578	SIGNOR-179250

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CHEK1	phosphorylation up-regulates →	TRIM28 PSer473	phosphorylation up-regulates →	TRIM28	21851590	SIGNOR-280226
CHEK2	phosphorylation up-regulates →	TRIM28 PSer473	phosphorylation down-regulates ⊣	TRIM28	26158765	SIGNOR-279730
PPP1CA	dephosphorylation down-regulates ⊣	TRIM28 PSer824	dephosphorylation down-regulates ⊣	TRIM28	20424263	SIGNOR-277075
RIPK3	phosphorylation up-regulates →	TRIM28 PSer473	phosphorylation down-regulates ⊣	TRIM28	34419074	SIGNOR-279107
PRKCD	phosphorylation up-regulates →	TRIM28 PSer473	phosphorylation down-regulates ⊣	TRIM28	18590578	SIGNOR-179250

Regulator	Mechanism/Effect	Target	SIGNOR-ID
SRC	phosphorylation → down-regulates activity	TRIM28	SIGNOR-280137
CHEK1	phosphorylation → up-regulates activity	TRIM28	SIGNOR-280226
PPP4C	dephosphorylation → down-regulates activity	TRIM28	SIGNOR-277163
CHEK2	phosphorylation → down-regulates activity	TRIM28	SIGNOR-279730
PPP1CA	dephosphorylation → up-regulates activity	TRIM28	SIGNOR-277075
RIPK3	phosphorylation → down-regulates activity	TRIM28	SIGNOR-279107
PRKCD	phosphorylation down-regulates	TRIM28	SIGNOR-179250