Entity Details

Name CHEK2_Ser473
ID Q13263
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PRKCDTRIM28Ser473SGVKRSRsGEGEVSGphosphorylation
down-regulates		18590578SIGNOR-179250
CHEK1TRIM28Ser473SGVKRSRsGEGEVSGphosphorylation
up-regulates activity		21851590SIGNOR-280226
CHEK2TRIM28Ser473SGVKRSRsGEGEVSGphosphorylation
down-regulates activity		26158765SIGNOR-279730
RIPK3TRIM28Ser473SGVKRSRsGEGEVSGphosphorylation
down-regulates activity		34419074SIGNOR-279107
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PRKCDphosphorylation
up-regulates
→
TRIM28
PSer473		phosphorylation
down-regulates
⊣		TRIM2818590578SIGNOR-179250
CHEK1phosphorylation
up-regulates
→
TRIM28
PSer473		phosphorylation
up-regulates
→		TRIM2821851590SIGNOR-280226
CHEK2phosphorylation
up-regulates
→
TRIM28
PSer473		phosphorylation
down-regulates
⊣		TRIM2826158765SIGNOR-279730
RIPK3phosphorylation
up-regulates
→
TRIM28
PSer473		phosphorylation
down-regulates
⊣		TRIM2834419074SIGNOR-279107
Regulator Mechanism/Effect Target SIGNOR-ID
PRKCDphosphorylation
img/direct_inhibition.png
down-regulates 		TRIM28SIGNOR-179250
CHEK1phosphorylation
→
up-regulates activity 		TRIM28SIGNOR-280226
CHEK2phosphorylation
→
down-regulates activity 		TRIM28SIGNOR-279730
RIPK3phosphorylation
→
down-regulates activity 		TRIM28SIGNOR-279107