| Name | ATM |
| ID | Q13315 |
| Role | substrate |
| Enzymatic Domains |
FAT 1940-2566 PROSITE-ProRule
PI3K/PI4K catalytic 2686-2998 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5 | ATM | Ser794 | LSNCTKKsPNKIASG | phosphorylation up-regulates | 19151707 | SIGNOR-183454 |
| PPM1D | ATM | – | dephosphorylation down-regulates | 19360021 | SIGNOR-185135 | |
| ATM | ATM | Ser1981 | SLAFEEGsQSTTISS | phosphorylation up-regulates activity | 21149446 | SIGNOR-170469 |
| ATM | ATM | Ser367 | DTRSLEIsQSYTTTQ | phosphorylation up-regulates activity | 21149446 | SIGNOR-170477 |
| PRKDC | ATM | Ser1987 | GSQSTTIsSLSEKSK | phosphorylation down-regulates activity | 32832608 | SIGNOR-278324 |
| ATM | ATM | Ser440 | SPLLMILsQLLPQQR | phosphorylation unknown | 10608806 | SIGNOR-250576 |
| ATM | ATM | Ser1893 | PANLDSEsEHFFRCC | phosphorylation up-regulates activity | 21149446 | SIGNOR-170465 |
| CSNK1A1 | ATM | Ser1270 | SHFDEVKsIANQIQE | phosphorylation down-regulates quantity by destabilization | 37075701 | SIGNOR-277918 |
| AURKB | ATM | Ser1403 | CHKTKLKsILEILSK | phosphorylation up-regulates | 22099307 | SIGNOR-177280 |
| EGFR | ATM | Tyr370 | SLEISQSyTTTQRES | phosphorylation up-regulates activity | 25601159 | SIGNOR-276872 |
| PPP2CB | ATM | Ser1981 | SLAFEEGsQSTTISS | dephosphorylation down-regulates activity | 15510216 | SIGNOR-248601 |
| ATR | ATM | Ser1981 | SLAFEEGsQSTTISS | phosphorylation up-regulates activity | 17124492 | SIGNOR-150870 |
| RPS6KA3 | ATM | Ser1981 | SLAFEEGsQSTTISS | phosphorylation up-regulates activity | 24086335 | SIGNOR-280118 |
| PPM1D | ATM | Ser1981 | SLAFEEGsQSTTISS | dephosphorylation down-regulates activity | 18265945 | SIGNOR-276954 |
| PPM1G | ATM | – | dephosphorylation down-regulates activity | 22361354 | SIGNOR-277158 | |
| PPM1D | ATM | Ser1981 | SLAFEEGsQSTTISS | dephosphorylation down-regulates activity | 16949371 | SIGNOR-248325 |
| PPP2CA | ATM | Ser1981 | SLAFEEGsQSTTISS | dephosphorylation down-regulates activity | 15510216 | SIGNOR-248644 |
| PPM1D | ATM | Ser367 | DTRSLEIsQSYTTTQ | dephosphorylation down-regulates activity | 18265945 | SIGNOR-276955 |
| ATM | ATM | Ser2996 | QECKRNLsDIDQSFN | phosphorylation up-regulates activity | 21149446 | SIGNOR-170473 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5 | phosphorylation up-regulates → | ATM PSer794 | phosphorylation up-regulates → | ATM | 19151707 | SIGNOR-183454 |
| ATM | phosphorylation up-regulates → | ATM PSer1981 | phosphorylation up-regulates → | ATM | 21149446 | SIGNOR-170469 |
| ATM | phosphorylation up-regulates → | ATM PSer367 | phosphorylation up-regulates → | ATM | 21149446 | SIGNOR-170477 |
| PRKDC | phosphorylation up-regulates → | ATM PSer1987 | phosphorylation down-regulates ⊣ | ATM | 32832608 | SIGNOR-278324 |
| ATM | phosphorylation up-regulates → | ATM PSer440 | phosphorylation down-regulates ⊣ | ATM | 10608806 | SIGNOR-250576 |
| ATM | phosphorylation up-regulates → | ATM PSer1893 | phosphorylation up-regulates → | ATM | 21149446 | SIGNOR-170465 |
| CSNK1A1 | phosphorylation up-regulates → | ATM PSer1270 | phosphorylation down-regulates ⊣ | ATM | 37075701 | SIGNOR-277918 |
| AURKB | phosphorylation up-regulates → | ATM PSer1403 | phosphorylation up-regulates → | ATM | 22099307 | SIGNOR-177280 |
| EGFR | phosphorylation up-regulates → | ATM PTyr370 | phosphorylation up-regulates → | ATM | 25601159 | SIGNOR-276872 |
| PPP2CB | dephosphorylation down-regulates ⊣ | ATM PSer1981 | dephosphorylation up-regulates → | ATM | 15510216 | SIGNOR-248601 |
| ATR | phosphorylation up-regulates → | ATM PSer1981 | phosphorylation up-regulates → | ATM | 17124492 | SIGNOR-150870 |
| RPS6KA3 | phosphorylation up-regulates → | ATM PSer1981 | phosphorylation up-regulates → | ATM | 24086335 | SIGNOR-280118 |
| PPM1D | dephosphorylation down-regulates ⊣ | ATM PSer1981 | dephosphorylation up-regulates → | ATM | 18265945 | SIGNOR-276954 |
| PPM1D | dephosphorylation down-regulates ⊣ | ATM PSer1981 | dephosphorylation up-regulates → | ATM | 16949371 | SIGNOR-248325 |
| PPP2CA | dephosphorylation down-regulates ⊣ | ATM PSer1981 | dephosphorylation up-regulates → | ATM | 15510216 | SIGNOR-248644 |
| PPM1D | dephosphorylation down-regulates ⊣ | ATM PSer367 | dephosphorylation up-regulates → | ATM | 18265945 | SIGNOR-276955 |
| ATM | phosphorylation up-regulates → | ATM PSer2996 | phosphorylation up-regulates → | ATM | 21149446 | SIGNOR-170473 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK5 | phosphorylation → up-regulates | ATM | SIGNOR-183454 |
| PPM1D | dephosphorylation down-regulates | ATM | SIGNOR-185135 |
| ATM | phosphorylation → up-regulates activity | ATM | SIGNOR-170469 |
| ATM | phosphorylation → up-regulates activity | ATM | SIGNOR-170477 |
| PRKDC | phosphorylation → down-regulates activity | ATM | SIGNOR-278324 |
| ATM | phosphorylation → unknown | ATM | SIGNOR-250576 |
| ATM | phosphorylation → up-regulates activity | ATM | SIGNOR-170465 |
| CSNK1A1 | phosphorylation down-regulates quantity by destabilization | ATM | SIGNOR-277918 |
| AURKB | phosphorylation → up-regulates | ATM | SIGNOR-177280 |
| EGFR | phosphorylation → up-regulates activity | ATM | SIGNOR-276872 |
| PPP2CB | dephosphorylation → down-regulates activity | ATM | SIGNOR-248601 |
| ATR | phosphorylation → up-regulates activity | ATM | SIGNOR-150870 |
| RPS6KA3 | phosphorylation → up-regulates activity | ATM | SIGNOR-280118 |
| PPM1D | dephosphorylation → down-regulates activity | ATM | SIGNOR-276954 |
| PPM1G | dephosphorylation → down-regulates activity | ATM | SIGNOR-277158 |
| PPM1D | dephosphorylation → down-regulates activity | ATM | SIGNOR-248325 |
| PPP2CA | dephosphorylation → down-regulates activity | ATM | SIGNOR-248644 |
| PPM1D | dephosphorylation → down-regulates activity | ATM | SIGNOR-276955 |
| ATM | phosphorylation → up-regulates activity | ATM | SIGNOR-170473 |