Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PPM1D	ATM	Ser367 View in OncoXplorer	DTRSLEIsQSYTTTQ	dephosphorylation down-regulates activity	18265945	SIGNOR-276955
ATM	ATM	Ser367 View in OncoXplorer	DTRSLEIsQSYTTTQ	phosphorylation up-regulates activity	21149446	SIGNOR-170477

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PPM1D	dephosphorylation down-regulates ⊣	ATM PSer367	dephosphorylation up-regulates →	ATM	18265945	SIGNOR-276955
ATM	phosphorylation up-regulates →	ATM PSer367	phosphorylation up-regulates →	ATM	21149446	SIGNOR-170477

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PPM1D	dephosphorylation → down-regulates activity	ATM	SIGNOR-276955
ATM	phosphorylation → up-regulates activity	ATM	SIGNOR-170477