| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | ATM | Ser1981 | SLAFEEGsQSTTISS | dephosphorylation down-regulates activity | 16949371 | SIGNOR-248325 |
| ATM | ATM | Ser1981 | SLAFEEGsQSTTISS | phosphorylation up-regulates activity | 21149446 | SIGNOR-170469 |
| RPS6KA3 | ATM | Ser1981 | SLAFEEGsQSTTISS | phosphorylation up-regulates activity | 24086335 | SIGNOR-280118 |
| PPM1D | ATM | Ser1981 | SLAFEEGsQSTTISS | dephosphorylation down-regulates activity | 18265945 | SIGNOR-276954 |
| ATR | ATM | Ser1981 | SLAFEEGsQSTTISS | phosphorylation up-regulates activity | 17124492 | SIGNOR-150870 |
| PPP2CA | ATM | Ser1981 | SLAFEEGsQSTTISS | dephosphorylation down-regulates activity | 15510216 | SIGNOR-248644 |
| PPP2CB | ATM | Ser1981 | SLAFEEGsQSTTISS | dephosphorylation down-regulates activity | 15510216 | SIGNOR-248601 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | dephosphorylation down-regulates ⊣ | ATM PSer1981 | dephosphorylation up-regulates → | ATM | 16949371 | SIGNOR-248325 |
| ATM | phosphorylation up-regulates → | ATM PSer1981 | phosphorylation up-regulates → | ATM | 21149446 | SIGNOR-170469 |
| RPS6KA3 | phosphorylation up-regulates → | ATM PSer1981 | phosphorylation up-regulates → | ATM | 24086335 | SIGNOR-280118 |
| PPM1D | dephosphorylation down-regulates ⊣ | ATM PSer1981 | dephosphorylation up-regulates → | ATM | 18265945 | SIGNOR-276954 |
| ATR | phosphorylation up-regulates → | ATM PSer1981 | phosphorylation up-regulates → | ATM | 17124492 | SIGNOR-150870 |
| PPP2CA | dephosphorylation down-regulates ⊣ | ATM PSer1981 | dephosphorylation up-regulates → | ATM | 15510216 | SIGNOR-248644 |
| PPP2CB | dephosphorylation down-regulates ⊣ | ATM PSer1981 | dephosphorylation up-regulates → | ATM | 15510216 | SIGNOR-248601 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1D | dephosphorylation → down-regulates activity | ATM | SIGNOR-248325 |
| ATM | phosphorylation → up-regulates activity | ATM | SIGNOR-170469 |
| RPS6KA3 | phosphorylation → up-regulates activity | ATM | SIGNOR-280118 |
| PPM1D | dephosphorylation → down-regulates activity | ATM | SIGNOR-276954 |
| ATR | phosphorylation → up-regulates activity | ATM | SIGNOR-150870 |
| PPP2CA | dephosphorylation → down-regulates activity | ATM | SIGNOR-248644 |
| PPP2CB | dephosphorylation → down-regulates activity | ATM | SIGNOR-248601 |
