| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | ATM | Ser367 | DTRSLEIsQSYTTTQ | dephosphorylation down-regulates activity | 18265945 | SIGNOR-276955 |
| ATM | ATM | Ser367 | DTRSLEIsQSYTTTQ | phosphorylation up-regulates activity | 21149446 | SIGNOR-170477 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | dephosphorylation down-regulates ⊣ | ATM PSer367 | dephosphorylation up-regulates → | ATM | 18265945 | SIGNOR-276955 |
| ATM | phosphorylation up-regulates → | ATM PSer367 | phosphorylation up-regulates → | ATM | 21149446 | SIGNOR-170477 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1D | dephosphorylation → down-regulates activity | ATM | SIGNOR-276955 |
| ATM | phosphorylation → up-regulates activity | ATM | SIGNOR-170477 |
