| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | CTBP1 | Ser422 | AHPPHAPsPGQTVKP | phosphorylation down-regulates | 16984892 | SIGNOR-149721 |
| AKT1 | CTBP1 | – | phosphorylation down-regulates quantity | 20361981 | SIGNOR-278304 | |
| PRKAA1 | CTBP1 | Ser158 | REGTRVQsVEQIREV | phosphorylation down-regulates | 23291169 | SIGNOR-200250 |
| AMPK | CTBP1 | Ser158 | REGTRVQsVEQIREV | phosphorylation down-regulates | 23291169 | SIGNOR-216604 |
| HIPK2 | CTBP1 | Ser422 | AHPPHAPsPGQTVKP | phosphorylation down-regulates | 15708980 | SIGNOR-134040 |
| PAK1 | CTBP1 | Ser158 | REGTRVQsVEQIREV | phosphorylation down-regulates activity | 12872159 | SIGNOR-103943 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | phosphorylation up-regulates → | CTBP1 PSer422 | phosphorylation down-regulates ⊣ | CTBP1 | 16984892 | SIGNOR-149721 |
| PRKAA1 | phosphorylation up-regulates → | CTBP1 PSer158 | phosphorylation down-regulates ⊣ | CTBP1 | 23291169 | SIGNOR-200250 |
| AMPK | phosphorylation up-regulates → | CTBP1 PSer158 | phosphorylation down-regulates ⊣ | CTBP1 | 23291169 | SIGNOR-216604 |
| HIPK2 | phosphorylation up-regulates → | CTBP1 PSer422 | phosphorylation down-regulates ⊣ | CTBP1 | 15708980 | SIGNOR-134040 |
| PAK1 | phosphorylation up-regulates → | CTBP1 PSer158 | phosphorylation down-regulates ⊣ | CTBP1 | 12872159 | SIGNOR-103943 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK8 | phosphorylation down-regulates | CTBP1 | SIGNOR-149721 |
| AKT1 | phosphorylation → down-regulates quantity | CTBP1 | SIGNOR-278304 |
| PRKAA1 | phosphorylation down-regulates | CTBP1 | SIGNOR-200250 |
| AMPK | phosphorylation down-regulates | CTBP1 | SIGNOR-216604 |
| HIPK2 | phosphorylation down-regulates | CTBP1 | SIGNOR-134040 |
| PAK1 | phosphorylation → down-regulates activity | CTBP1 | SIGNOR-103943 |
