| Name | PDE3B |
| ID | Q13370 |
| Role | substrate |
| Enzymatic Domains |
PDEase 651-1079 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | PDE3B | Ser295 | VIRPRRRsSCVSLGE | phosphorylation up-regulates | 10454575 | SIGNOR-70205 |
| AKT1 | PDE3B | Ser318 | CKIFRRPsLPCISRE | phosphorylation up-regulates activity | 10454575 | SIGNOR-252554 |
| IKBKE | PDE3B | – | phosphorylation up-regulates activity | 29425491 | SIGNOR-278517 | |
| AKT | PDE3B | Ser318 | CKIFRRPsLPCISRE | phosphorylation up-regulates activity | 10454575 | SIGNOR-248027 |
| PRKACA | PDE3B | Ser442 | TPQLRRSsGTSGLLP | phosphorylation unknown | 8163498 | SIGNOR-250023 |
| AKT1 | PDE3B | Ser295 | VIRPRRRsSCVSLGE | phosphorylation up-regulates activity | 10454575 | SIGNOR-252573 |
| AKT | PDE3B | Ser295 | VIRPRRRsSCVSLGE | phosphorylation up-regulates activity | 10454575 | SIGNOR-251483 |
| AKT1 | PDE3B | Ser295 | VIRPRRRsSCVSLGE | phosphorylation up-regulates | 10454575 | SIGNOR-252583 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | PDE3B PSer295 | phosphorylation up-regulates → | PDE3B | 10454575 | SIGNOR-70205 |
| AKT1 | phosphorylation up-regulates → | PDE3B PSer318 | phosphorylation up-regulates → | PDE3B | 10454575 | SIGNOR-252554 |
| AKT | phosphorylation up-regulates → | PDE3B PSer318 | phosphorylation up-regulates → | PDE3B | 10454575 | SIGNOR-248027 |
| PRKACA | phosphorylation up-regulates → | PDE3B PSer442 | phosphorylation down-regulates ⊣ | PDE3B | 8163498 | SIGNOR-250023 |
| AKT1 | phosphorylation up-regulates → | PDE3B PSer295 | phosphorylation up-regulates → | PDE3B | 10454575 | SIGNOR-252573 |
| AKT | phosphorylation up-regulates → | PDE3B PSer295 | phosphorylation up-regulates → | PDE3B | 10454575 | SIGNOR-251483 |
| AKT1 | phosphorylation up-regulates → | PDE3B PSer295 | phosphorylation up-regulates → | PDE3B | 10454575 | SIGNOR-252583 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → up-regulates | PDE3B | SIGNOR-70205 |
| AKT1 | phosphorylation → up-regulates activity | PDE3B | SIGNOR-252554 |
| IKBKE | phosphorylation → up-regulates activity | PDE3B | SIGNOR-278517 |
| AKT | phosphorylation → up-regulates activity | PDE3B | SIGNOR-248027 |
| PRKACA | phosphorylation → unknown | PDE3B | SIGNOR-250023 |
| AKT1 | phosphorylation → up-regulates activity | PDE3B | SIGNOR-252573 |
| AKT | phosphorylation → up-regulates activity | PDE3B | SIGNOR-251483 |
| AKT1 | phosphorylation → up-regulates | PDE3B | SIGNOR-252583 |