| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinA2/CDK2 | ORC2 | Thr226 | SAPVGKEtPSKRMKR | phosphorylation up-regulates | 11931757 | SIGNOR-217308 |
| CDK2 | ORC2 | Thr226 | SAPVGKEtPSKRMKR | phosphorylation up-regulates | 22334659 | SIGNOR-196048 |
| CyclinA2/CDK2 | ORC2 | Thr116 | LASELAKtPQKSVSF | phosphorylation up-regulates | 11931757 | SIGNOR-217296 |
| CDK2 | ORC2 | Thr116 | LASELAKtPQKSVSF | phosphorylation up-regulates | 11931757 | SIGNOR-116364 |
| CDK2 | ORC2 | Thr226 | SAPVGKEtPSKRMKR | phosphorylation up-regulates | 11931757 | SIGNOR-116476 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinA2/CDK2 | phosphorylation up-regulates → | ORC2 PThr226 | phosphorylation up-regulates → | ORC2 | 11931757 | SIGNOR-217308 |
| CDK2 | phosphorylation up-regulates → | ORC2 PThr226 | phosphorylation up-regulates → | ORC2 | 22334659 | SIGNOR-196048 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | ORC2 PThr116 | phosphorylation up-regulates → | ORC2 | 11931757 | SIGNOR-217296 |
| CDK2 | phosphorylation up-regulates → | ORC2 PThr116 | phosphorylation up-regulates → | ORC2 | 11931757 | SIGNOR-116364 |
| CDK2 | phosphorylation up-regulates → | ORC2 PThr226 | phosphorylation up-regulates → | ORC2 | 11931757 | SIGNOR-116476 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinA2/CDK2 | phosphorylation → up-regulates | ORC2 | SIGNOR-217308 |
| CDK2 | phosphorylation → up-regulates | ORC2 | SIGNOR-196048 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | ORC2 | SIGNOR-217296 |
| CDK2 | phosphorylation → up-regulates | ORC2 | SIGNOR-116364 |
| CDK2 | phosphorylation → up-regulates | ORC2 | SIGNOR-116476 |
