Entity Details

Name ILK
ID Q13418
Role kinase
Enzymatic Domains
Protein kinase 193-446
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ILKNACASer1906PELEEQDsTQATTQQphosphorylation
up-regulates
15299025SIGNOR-127631
ILKMYL12BSer20KRPQRATsNVFAMFDphosphorylation
up-regulates activity
11278951SIGNOR-106423
ILKMYL12BThr19KKRPQRAtSNVFAMFphosphorylation
up-regulates activity
11278951SIGNOR-106427
ILKPPP1R12AThr696ARQSRRStQGVTLTDphosphorylation
down-regulates
12030846SIGNOR-87924
ILKPPP1R12AThr710DLQEAEKtIGRSRSTphosphorylation
down-regulates
12030846SIGNOR-87928
ILKPPP1R12AThr500RLAYVAPtIPRRLASphosphorylation
down-regulates activity
12030846SIGNOR-262884
ILKPPP1R12AThr696ARQSRRStQGVTLTDphosphorylation
down-regulates activity
12030846SIGNOR-262886
ILKPPP1R12AThr710DLQEAEKtIGRSRSTphosphorylation
down-regulates activity
12030846SIGNOR-262885
ILKCFL1Ser3sGVAVSDGphosphorylation
down-regulates
18252715SIGNOR-160756
ILKAKT1Ser473RPHFPQFsYSASGTAphosphorylation
up-regulates
9736715SIGNOR-252597
ILKAKT1Ser473RPHFPQFsYSASGTAphosphorylation
up-regulates activity
11313365SIGNOR-252596
ILKAKT2Ser474RTHFPQFsYSASIREphosphorylation
up-regulates activity
19460343SIGNOR-279055
ILKGSK3BSer9SGRPRTTsFAESCKPphosphorylation
down-regulates activity
27683053SIGNOR-278252
ILKILKSer343SMADVKFsFQCPGRMphosphorylation
up-regulates activity
11313365SIGNOR-106838
ILKNACASer43PELEEQDsTQATTQQphosphorylation
up-regulates
15299025SIGNOR-127694
ILKPPP1R14CThr73RHQQGKVtVKYDRKEphosphorylation
up-regulates activity
12804574SIGNOR-101835
ILKPPP1R14AThr38QKRHARVtVKYDRREphosphorylation
up-regulates activity
12144526SIGNOR-90828
ILKPPP1R14BThr57VRRQGKVtVKYDRKEphosphorylation
up-regulates activity
12144526SIGNOR-265741
ILKPARVB–phosphorylation
up-regulates activity
15159419SIGNOR-278259
ILKSYNPO2–phosphorylation
up-regulates activity
21643011SIGNOR-279622
ILKAKTSer473RPHFPQFsYSASGTAphosphorylation
up-regulates
9736715SIGNOR-60115
ILKAKTSer473RPHFPQFsYSASGTAphosphorylation
up-regulates activity
11313365SIGNOR-250261
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ILKphosphorylation
up-regulates
→
NACA
PSer1906
phosphorylation
up-regulates
→
NACA15299025SIGNOR-127631
ILKphosphorylation
up-regulates
→
MYL12B
PSer20
phosphorylation
up-regulates
→
MYL12B11278951SIGNOR-106423
ILKphosphorylation
up-regulates
→
MYL12B
PThr19
phosphorylation
up-regulates
→
MYL12B11278951SIGNOR-106427
ILKphosphorylation
up-regulates
→
PPP1R12A
PThr696
phosphorylation
down-regulates
⊣
PPP1R12A12030846SIGNOR-87924
ILKphosphorylation
up-regulates
→
PPP1R12A
PThr710
phosphorylation
down-regulates
⊣
PPP1R12A12030846SIGNOR-87928
ILKphosphorylation
up-regulates
→
PPP1R12A
PThr500
phosphorylation
down-regulates
⊣
PPP1R12A12030846SIGNOR-262884
ILKphosphorylation
up-regulates
→
PPP1R12A
PThr696
phosphorylation
down-regulates
⊣
PPP1R12A12030846SIGNOR-262886
ILKphosphorylation
up-regulates
→
PPP1R12A
PThr710
phosphorylation
down-regulates
⊣
PPP1R12A12030846SIGNOR-262885
ILKphosphorylation
up-regulates
→
CFL1
PSer3
phosphorylation
down-regulates
⊣
CFL118252715SIGNOR-160756
ILKphosphorylation
up-regulates
→
AKT1
PSer473
phosphorylation
up-regulates
→
AKT19736715SIGNOR-252597
ILKphosphorylation
up-regulates
→
AKT1
PSer473
phosphorylation
up-regulates
→
AKT111313365SIGNOR-252596
ILKphosphorylation
up-regulates
→
AKT2
PSer474
phosphorylation
up-regulates
→
AKT219460343SIGNOR-279055
ILKphosphorylation
up-regulates
→
GSK3B
PSer9
phosphorylation
down-regulates
⊣
GSK3B27683053SIGNOR-278252
ILKphosphorylation
up-regulates
→
ILK
PSer343
phosphorylation
up-regulates
→
ILK11313365SIGNOR-106838
ILKphosphorylation
up-regulates
→
NACA
PSer43
phosphorylation
up-regulates
→
NACA15299025SIGNOR-127694
ILKphosphorylation
up-regulates
→
PPP1R14C
PThr73
phosphorylation
up-regulates
→
PPP1R14C12804574SIGNOR-101835
ILKphosphorylation
up-regulates
→
PPP1R14A
PThr38
phosphorylation
up-regulates
→
PPP1R14A12144526SIGNOR-90828
ILKphosphorylation
up-regulates
→
PPP1R14B
PThr57
phosphorylation
up-regulates
→
PPP1R14B12144526SIGNOR-265741
ILKphosphorylation
up-regulates
→
AKT
PSer473
phosphorylation
up-regulates
→
AKT9736715SIGNOR-60115
ILKphosphorylation
up-regulates
→
AKT
PSer473
phosphorylation
up-regulates
→
AKT11313365SIGNOR-250261
Regulator Mechanism/Effect Target SIGNOR-ID
ILKphosphorylation
→
up-regulates
NACASIGNOR-127631
ILKphosphorylation
→
up-regulates activity
MYL12BSIGNOR-106423
ILKphosphorylation
→
up-regulates activity
MYL12BSIGNOR-106427
ILKphosphorylation
img/direct_inhibition.png
down-regulates
PPP1R12ASIGNOR-87924
ILKphosphorylation
img/direct_inhibition.png
down-regulates
PPP1R12ASIGNOR-87928
ILKphosphorylation
→
down-regulates activity
PPP1R12ASIGNOR-262884
ILKphosphorylation
→
down-regulates activity
PPP1R12ASIGNOR-262886
ILKphosphorylation
→
down-regulates activity
PPP1R12ASIGNOR-262885
ILKphosphorylation
img/direct_inhibition.png
down-regulates
CFL1SIGNOR-160756
ILKphosphorylation
→
up-regulates
AKT1SIGNOR-252597
ILKphosphorylation
→
up-regulates activity
AKT1SIGNOR-252596
ILKphosphorylation
→
up-regulates activity
AKT2SIGNOR-279055
ILKphosphorylation
→
down-regulates activity
GSK3BSIGNOR-278252
ILKphosphorylation
→
up-regulates activity
ILKSIGNOR-106838
ILKphosphorylation
→
up-regulates
NACASIGNOR-127694
ILKphosphorylation
→
up-regulates activity
PPP1R14CSIGNOR-101835
ILKphosphorylation
→
up-regulates activity
PPP1R14ASIGNOR-90828
ILKphosphorylation
→
up-regulates activity
PPP1R14BSIGNOR-265741
ILKphosphorylation
→
up-regulates activity
PARVBSIGNOR-278259
ILKphosphorylation
→
up-regulates activity
SYNPO2SIGNOR-279622
ILKphosphorylation
→
up-regulates
AKTSIGNOR-60115
ILKphosphorylation
→
up-regulates activity
AKTSIGNOR-250261