| Name | ADAM15 |
| ID | Q13444 |
| Role | substrate |
| Enzymatic Domains |
Peptidase M12B 213-414 PROSITE-ProRule
Disintegrin 421-508 PROSITE-ProRule
EGF-like 657-685 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | ADAM15 | Tyr735 | LKGPTCQyRAAQSGP | phosphorylation up-regulates | 11741929 | SIGNOR-112935 |
| LCK | ADAM15 | Tyr715 | LVMLGASyWYRARLH | phosphorylation up-regulates | 11741929 | SIGNOR-112931 |
| HCK | ADAM15 | Tyr735 | LKGPTCQyRAAQSGP | phosphorylation up-regulates | 11741929 | SIGNOR-112923 |
| HCK | ADAM15 | Tyr715 | LVMLGASyWYRARLH | phosphorylation up-regulates | 11741929 | SIGNOR-112919 |
| HCK | ADAM15 | Tyr715 | LVMLGASyWYRARLH | phosphorylation unknown | 11741929 | SIGNOR-112927 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | phosphorylation up-regulates → | ADAM15 PTyr735 | phosphorylation up-regulates → | ADAM15 | 11741929 | SIGNOR-112935 |
| LCK | phosphorylation up-regulates → | ADAM15 PTyr715 | phosphorylation up-regulates → | ADAM15 | 11741929 | SIGNOR-112931 |
| HCK | phosphorylation up-regulates → | ADAM15 PTyr735 | phosphorylation up-regulates → | ADAM15 | 11741929 | SIGNOR-112923 |
| HCK | phosphorylation up-regulates → | ADAM15 PTyr715 | phosphorylation up-regulates → | ADAM15 | 11741929 | SIGNOR-112919 |
| HCK | phosphorylation up-regulates → | ADAM15 PTyr715 | phosphorylation down-regulates ⊣ | ADAM15 | 11741929 | SIGNOR-112927 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LCK | phosphorylation → up-regulates | ADAM15 | SIGNOR-112935 |
| LCK | phosphorylation → up-regulates | ADAM15 | SIGNOR-112931 |
| HCK | phosphorylation → up-regulates | ADAM15 | SIGNOR-112923 |
| HCK | phosphorylation → up-regulates | ADAM15 | SIGNOR-112919 |
| HCK | phosphorylation → unknown | ADAM15 | SIGNOR-112927 |