| Name | TNK1 |
| ID | Q13470 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 116-377 PROSITE-ProRule
SH3 380-445 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MARK4 | TNK1 | Ser502 | RMKGISRsLESVLSL | phosphorylation down-regulates activity | 34504101 | SIGNOR-273865 |
| TNK1 | TNK1 | Tyr277 | LGGARGRyVMGGPRP | phosphorylation up-regulates activity | 36334623 | SIGNOR-274126 |
| MARK1 | TNK1 | Ser502 | RMKGISRsLESVLSL | phosphorylation down-regulates activity | 34504101 | SIGNOR-273866 |
| MARK3 | TNK1 | Ser502 | RMKGISRsLESVLSL | phosphorylation down-regulates activity | 34504101 | SIGNOR-273868 |
| MARK2 | TNK1 | Ser502 | RMKGISRsLESVLSL | phosphorylation down-regulates activity | 34504101 | SIGNOR-273867 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MARK4 | phosphorylation up-regulates → | TNK1 PSer502 | phosphorylation down-regulates ⊣ | TNK1 | 34504101 | SIGNOR-273865 |
| TNK1 | phosphorylation up-regulates → | TNK1 PTyr277 | phosphorylation up-regulates → | TNK1 | 36334623 | SIGNOR-274126 |
| MARK1 | phosphorylation up-regulates → | TNK1 PSer502 | phosphorylation down-regulates ⊣ | TNK1 | 34504101 | SIGNOR-273866 |
| MARK3 | phosphorylation up-regulates → | TNK1 PSer502 | phosphorylation down-regulates ⊣ | TNK1 | 34504101 | SIGNOR-273868 |
| MARK2 | phosphorylation up-regulates → | TNK1 PSer502 | phosphorylation down-regulates ⊣ | TNK1 | 34504101 | SIGNOR-273867 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MARK4 | phosphorylation → down-regulates activity | TNK1 | SIGNOR-273865 |
| TNK1 | phosphorylation → up-regulates activity | TNK1 | SIGNOR-274126 |
| MARK1 | phosphorylation → down-regulates activity | TNK1 | SIGNOR-273866 |
| MARK3 | phosphorylation → down-regulates activity | TNK1 | SIGNOR-273868 |
| MARK2 | phosphorylation → down-regulates activity | TNK1 | SIGNOR-273867 |