| Name | GAB1 |
| ID | Q13480 |
| Role | substrate |
| Enzymatic Domains |
PH 5-116 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| INSR | GAB1 | Tyr285 | TEADGELyVFNTPSG | phosphorylation up-regulates activity | 10978177 | SIGNOR-251311 |
| MET | GAB1 | Tyr627 | KGDKQVEyLDLDLDS | phosphorylation up-regulates activity | 10734310 | SIGNOR-250289 |
| ERK1/2 | GAB1 | Thr476 | EANYVPMtPGTFDFS | phosphorylation up-regulates activity | 15379552 | SIGNOR-129200 |
| INSR | GAB1 | Tyr472 | EPIQEANyVPMTPGT | phosphorylation up-regulates activity | 10978177 | SIGNOR-251314 |
| INSR | GAB1 | Tyr373 | ASDTDSSyCIPTAGM | phosphorylation up-regulates activity | 10978177 | SIGNOR-251312 |
| PTPN11 | GAB1 | Tyr589 | SHDSEENyVPMNPNL | dephosphorylation down-regulates activity | 10068651 | SIGNOR-236258 |
| EGFR | GAB1 | Tyr307 | MRHVSISyDIPPTPG | phosphorylation up-regulates activity | 10734310 | SIGNOR-233233 |
| MET | GAB1 | Tyr285 | TEADGELyVFNTPSG | phosphorylation up-regulates activity | 10734310 | SIGNOR-250552 |
| EGFR | GAB1 | Tyr447 | SEELDENyVPMNPNS | phosphorylation up-regulates | 9890893 | SIGNOR-236420 |
| MAPK1 | GAB1 | Ser551 | ELQAPVRsPITRSFA | phosphorylation up-regulates activity | 15379552 | SIGNOR-249397 |
| MAPK1 | GAB1 | Thr476 | EANYVPMtPGTFDFS | phosphorylation up-regulates activity | 15379552 | SIGNOR-249400 |
| INSR | GAB1 | Tyr242 | FFQQQMIyDSPPSRA | phosphorylation up-regulates activity | 10978177 | SIGNOR-251310 |
| PTPN1 | GAB1 | – | dephosphorylation down-regulates activity | 23521888 | SIGNOR-276965 | |
| MAPK3 | GAB1 | Thr312 | ISYDIPPtPGNTYQI | phosphorylation up-regulates activity | 15379552 | SIGNOR-249463 |
| INSR | GAB1 | Tyr659 | VADERVDyVVVDQQK | phosphorylation up-regulates activity | 10978177 | SIGNOR-251317 |
| EGFR | GAB1 | Tyr285 | TEADGELyVFNTPSG | phosphorylation up-regulates | 9890893 | SIGNOR-236400 |
| ERK1/2 | GAB1 | Ser597 | VPMNPNLsSEDPNLF | phosphorylation up-regulates activity | 15379552 | SIGNOR-129192 |
| PTPN11 | GAB1 | Tyr659 | VADERVDyVVVDQQK | dephosphorylation down-regulates | 10068651 | SIGNOR-236254 |
| MAPK3 | GAB1 | Ser454 | YVPMNPNsPPRQHSS | phosphorylation up-regulates activity | 15379552 | SIGNOR-249460 |
| SRC | GAB1 | Tyr627 | KGDKQVEyLDLDLDS | phosphorylation up-regulates activity | 19881549 | SIGNOR-236302 |
| MAPK1 | GAB1 | Ser381 | CIPTAGMsPSRSNTI | phosphorylation up-regulates activity | 15379552 | SIGNOR-249395 |
| Gbeta | GAB1 | – | phosphorylation up-regulates activity | 15379552 | SIGNOR-270060 | |
| MAPK1 | GAB1 | Thr312 | ISYDIPPtPGNTYQI | phosphorylation up-regulates activity | 15379552 | SIGNOR-249399 |
| MET | GAB1 | Tyr659 | VADERVDyVVVDQQK | phosphorylation up-regulates activity | 10734310 | SIGNOR-250290 |
| MAPK3 | GAB1 | Ser381 | CIPTAGMsPSRSNTI | phosphorylation up-regulates activity | 15379552 | SIGNOR-249459 |
| MAPK1 | GAB1 | Ser454 | YVPMNPNsPPRQHSS | phosphorylation up-regulates activity | 15379552 | SIGNOR-249396 |
| SRC | GAB1 | Tyr259 | ASVDSSLyNLPRSYS | phosphorylation up-regulates activity | 19881549 | SIGNOR-236310 |
| EGFR | GAB1 | Tyr406 | DASSQDCyDIPRAFP | phosphorylation up-regulates | 9890893 | SIGNOR-236396 |
| EGFR | GAB1 | Tyr659 | VADERVDyVVVDQQK | phosphorylation up-regulates | 9890893 | SIGNOR-236404 |
| SRC | GAB1 | Tyr373 | ASDTDSSyCIPTAGM | phosphorylation up-regulates activity | 19881549 | SIGNOR-236318 |
| PTPN11 | GAB1 | Tyr659 | VADERVDyVVVDQQK | dephosphorylation down-regulates activity | 11323411 | SIGNOR-248675 |
| INSR | GAB1 | Tyr627 | KGDKQVEyLDLDLDS | phosphorylation up-regulates activity | 10978177 | SIGNOR-251316 |
| EGFR | GAB1 | Tyr589 | SHDSEENyVPMNPNL | phosphorylation up-regulates activity | 9890893 | SIGNOR-236416 |
| MAPK3 | GAB1 | Ser551 | ELQAPVRsPITRSFA | phosphorylation up-regulates activity | 15379552 | SIGNOR-249461 |
| SRC | GAB1 | Tyr242 | FFQQQMIyDSPPSRA | phosphorylation up-regulates | 19881549 | SIGNOR-236314 |
| MAPK1 | GAB1 | Ser567 | DSSRFPMsPRPDSVH | phosphorylation up-regulates activity | 15379552 | SIGNOR-249398 |
| MET | GAB1 | Tyr589 | SHDSEENyVPMNPNL | phosphorylation up-regulates activity | 10734310 | SIGNOR-250288 |
| INSR | GAB1 | Tyr589 | SHDSEENyVPMNPNL | phosphorylation up-regulates activity | 10978177 | SIGNOR-251315 |
| EGFR | GAB1 | Tyr627 | KGDKQVEyLDLDLDS | phosphorylation up-regulates | 9890893 | SIGNOR-236392 |
| MAPK3 | GAB1 | Thr476 | EANYVPMtPGTFDFS | phosphorylation up-regulates activity | 15379552 | SIGNOR-249464 |
| PTPN11 | GAB1 | Tyr627 | KGDKQVEyLDLDLDS | dephosphorylation down-regulates activity | 11323411 | SIGNOR-248674 |
| EGFR | GAB1 | Tyr472 | EPIQEANyVPMTPGT | phosphorylation up-regulates activity | 9890893 | SIGNOR-236412 |
| SRC | GAB1 | Tyr317 | PPTPGNTyQIPRTFP | phosphorylation up-regulates activity | 19881549 | SIGNOR-236306 |
| ERK1/2 | GAB1 | Thr312 | ISYDIPPtPGNTYQI | phosphorylation up-regulates activity | 15379552 | SIGNOR-129196 |
| ERK1/2 | GAB1 | Ser454 | YVPMNPNsPPRQHSS | phosphorylation up-regulates activity | 15379552 | SIGNOR-129188 |
| MAPK3 | GAB1 | Ser567 | DSSRFPMsPRPDSVH | phosphorylation up-regulates activity | 15379552 | SIGNOR-249462 |
| INSR | GAB1 | Tyr447 | SEELDENyVPMNPNS | phosphorylation up-regulates activity | 10978177 | SIGNOR-251313 |
| EGFR | GAB1 | Tyr373 | ASDTDSSyCIPTAGM | phosphorylation up-regulates activity | 9890893 | SIGNOR-236408 |
| PTPN11 | GAB1 | Tyr627 | KGDKQVEyLDLDLDS | dephosphorylation down-regulates | 10068651 | SIGNOR-236262 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| INSR | phosphorylation up-regulates → | GAB1 PTyr285 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251311 |
| MET | phosphorylation up-regulates → | GAB1 PTyr627 | phosphorylation up-regulates → | GAB1 | 10734310 | SIGNOR-250289 |
| ERK1/2 | phosphorylation up-regulates → | GAB1 PThr476 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-129200 |
| INSR | phosphorylation up-regulates → | GAB1 PTyr472 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251314 |
| INSR | phosphorylation up-regulates → | GAB1 PTyr373 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251312 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GAB1 PTyr589 | dephosphorylation up-regulates → | GAB1 | 10068651 | SIGNOR-236258 |
| EGFR | phosphorylation up-regulates → | GAB1 PTyr307 | phosphorylation up-regulates → | GAB1 | 10734310 | SIGNOR-233233 |
| MET | phosphorylation up-regulates → | GAB1 PTyr285 | phosphorylation up-regulates → | GAB1 | 10734310 | SIGNOR-250552 |
| EGFR | phosphorylation up-regulates → | GAB1 PTyr447 | phosphorylation up-regulates → | GAB1 | 9890893 | SIGNOR-236420 |
| MAPK1 | phosphorylation up-regulates → | GAB1 PSer551 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-249397 |
| MAPK1 | phosphorylation up-regulates → | GAB1 PThr476 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-249400 |
| INSR | phosphorylation up-regulates → | GAB1 PTyr242 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251310 |
| MAPK3 | phosphorylation up-regulates → | GAB1 PThr312 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-249463 |
| INSR | phosphorylation up-regulates → | GAB1 PTyr659 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251317 |
| EGFR | phosphorylation up-regulates → | GAB1 PTyr285 | phosphorylation up-regulates → | GAB1 | 9890893 | SIGNOR-236400 |
| ERK1/2 | phosphorylation up-regulates → | GAB1 PSer597 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-129192 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GAB1 PTyr659 | dephosphorylation up-regulates → | GAB1 | 10068651 | SIGNOR-236254 |
| MAPK3 | phosphorylation up-regulates → | GAB1 PSer454 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-249460 |
| SRC | phosphorylation up-regulates → | GAB1 PTyr627 | phosphorylation up-regulates → | GAB1 | 19881549 | SIGNOR-236302 |
| MAPK1 | phosphorylation up-regulates → | GAB1 PSer381 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-249395 |
| MAPK1 | phosphorylation up-regulates → | GAB1 PThr312 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-249399 |
| MET | phosphorylation up-regulates → | GAB1 PTyr659 | phosphorylation up-regulates → | GAB1 | 10734310 | SIGNOR-250290 |
| MAPK3 | phosphorylation up-regulates → | GAB1 PSer381 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-249459 |
| MAPK1 | phosphorylation up-regulates → | GAB1 PSer454 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-249396 |
| SRC | phosphorylation up-regulates → | GAB1 PTyr259 | phosphorylation up-regulates → | GAB1 | 19881549 | SIGNOR-236310 |
| EGFR | phosphorylation up-regulates → | GAB1 PTyr406 | phosphorylation up-regulates → | GAB1 | 9890893 | SIGNOR-236396 |
| EGFR | phosphorylation up-regulates → | GAB1 PTyr659 | phosphorylation up-regulates → | GAB1 | 9890893 | SIGNOR-236404 |
| SRC | phosphorylation up-regulates → | GAB1 PTyr373 | phosphorylation up-regulates → | GAB1 | 19881549 | SIGNOR-236318 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GAB1 PTyr659 | dephosphorylation up-regulates → | GAB1 | 11323411 | SIGNOR-248675 |
| INSR | phosphorylation up-regulates → | GAB1 PTyr627 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251316 |
| EGFR | phosphorylation up-regulates → | GAB1 PTyr589 | phosphorylation up-regulates → | GAB1 | 9890893 | SIGNOR-236416 |
| MAPK3 | phosphorylation up-regulates → | GAB1 PSer551 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-249461 |
| SRC | phosphorylation up-regulates → | GAB1 PTyr242 | phosphorylation up-regulates → | GAB1 | 19881549 | SIGNOR-236314 |
| MAPK1 | phosphorylation up-regulates → | GAB1 PSer567 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-249398 |
| MET | phosphorylation up-regulates → | GAB1 PTyr589 | phosphorylation up-regulates → | GAB1 | 10734310 | SIGNOR-250288 |
| INSR | phosphorylation up-regulates → | GAB1 PTyr589 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251315 |
| EGFR | phosphorylation up-regulates → | GAB1 PTyr627 | phosphorylation up-regulates → | GAB1 | 9890893 | SIGNOR-236392 |
| MAPK3 | phosphorylation up-regulates → | GAB1 PThr476 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-249464 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GAB1 PTyr627 | dephosphorylation up-regulates → | GAB1 | 11323411 | SIGNOR-248674 |
| EGFR | phosphorylation up-regulates → | GAB1 PTyr472 | phosphorylation up-regulates → | GAB1 | 9890893 | SIGNOR-236412 |
| SRC | phosphorylation up-regulates → | GAB1 PTyr317 | phosphorylation up-regulates → | GAB1 | 19881549 | SIGNOR-236306 |
| ERK1/2 | phosphorylation up-regulates → | GAB1 PThr312 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-129196 |
| ERK1/2 | phosphorylation up-regulates → | GAB1 PSer454 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-129188 |
| MAPK3 | phosphorylation up-regulates → | GAB1 PSer567 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-249462 |
| INSR | phosphorylation up-regulates → | GAB1 PTyr447 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251313 |
| EGFR | phosphorylation up-regulates → | GAB1 PTyr373 | phosphorylation up-regulates → | GAB1 | 9890893 | SIGNOR-236408 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GAB1 PTyr627 | dephosphorylation up-regulates → | GAB1 | 10068651 | SIGNOR-236262 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251311 |
| MET | phosphorylation → up-regulates activity | GAB1 | SIGNOR-250289 |
| ERK1/2 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-129200 |
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251314 |
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251312 |
| PTPN11 | dephosphorylation → down-regulates activity | GAB1 | SIGNOR-236258 |
| EGFR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-233233 |
| MET | phosphorylation → up-regulates activity | GAB1 | SIGNOR-250552 |
| EGFR | phosphorylation → up-regulates | GAB1 | SIGNOR-236420 |
| MAPK1 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-249397 |
| MAPK1 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-249400 |
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251310 |
| PTPN1 | dephosphorylation → down-regulates activity | GAB1 | SIGNOR-276965 |
| MAPK3 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-249463 |
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251317 |
| EGFR | phosphorylation → up-regulates | GAB1 | SIGNOR-236400 |
| ERK1/2 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-129192 |
| PTPN11 | dephosphorylation down-regulates | GAB1 | SIGNOR-236254 |
| MAPK3 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-249460 |
| SRC | phosphorylation → up-regulates activity | GAB1 | SIGNOR-236302 |
| MAPK1 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-249395 |
| Gbeta | phosphorylation → up-regulates activity | GAB1 | SIGNOR-270060 |
| MAPK1 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-249399 |
| MET | phosphorylation → up-regulates activity | GAB1 | SIGNOR-250290 |
| MAPK3 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-249459 |
| MAPK1 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-249396 |
| SRC | phosphorylation → up-regulates activity | GAB1 | SIGNOR-236310 |
| EGFR | phosphorylation → up-regulates | GAB1 | SIGNOR-236396 |
| EGFR | phosphorylation → up-regulates | GAB1 | SIGNOR-236404 |
| SRC | phosphorylation → up-regulates activity | GAB1 | SIGNOR-236318 |
| PTPN11 | dephosphorylation → down-regulates activity | GAB1 | SIGNOR-248675 |
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251316 |
| EGFR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-236416 |
| MAPK3 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-249461 |
| SRC | phosphorylation → up-regulates | GAB1 | SIGNOR-236314 |
| MAPK1 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-249398 |
| MET | phosphorylation → up-regulates activity | GAB1 | SIGNOR-250288 |
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251315 |
| EGFR | phosphorylation → up-regulates | GAB1 | SIGNOR-236392 |
| MAPK3 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-249464 |
| PTPN11 | dephosphorylation → down-regulates activity | GAB1 | SIGNOR-248674 |
| EGFR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-236412 |
| SRC | phosphorylation → up-regulates activity | GAB1 | SIGNOR-236306 |
| ERK1/2 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-129196 |
| ERK1/2 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-129188 |
| MAPK3 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-249462 |
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251313 |
| EGFR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-236408 |
| PTPN11 | dephosphorylation down-regulates | GAB1 | SIGNOR-236262 |