| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | GAB1 | Tyr285 | TEADGELyVFNTPSG | phosphorylation up-regulates | 9890893 | SIGNOR-236400 |
| MET | GAB1 | Tyr285 | TEADGELyVFNTPSG | phosphorylation up-regulates activity | 10734310 | SIGNOR-250552 |
| INSR | GAB1 | Tyr285 | TEADGELyVFNTPSG | phosphorylation up-regulates activity | 10978177 | SIGNOR-251311 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | phosphorylation up-regulates → | GAB1 PTyr285 | phosphorylation up-regulates → | GAB1 | 9890893 | SIGNOR-236400 |
| MET | phosphorylation up-regulates → | GAB1 PTyr285 | phosphorylation up-regulates → | GAB1 | 10734310 | SIGNOR-250552 |
| INSR | phosphorylation up-regulates → | GAB1 PTyr285 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251311 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EGFR | phosphorylation → up-regulates | GAB1 | SIGNOR-236400 |
| MET | phosphorylation → up-regulates activity | GAB1 | SIGNOR-250552 |
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251311 |
