Entity Details

Name EGFR_Tyr447
ID Q13480
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
EGFRGAB1Tyr447SEELDENyVPMNPNSphosphorylation
up-regulates		9890893SIGNOR-236420
INSRGAB1Tyr447SEELDENyVPMNPNSphosphorylation
up-regulates activity		10978177SIGNOR-251313
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
EGFRphosphorylation
up-regulates
→
GAB1
PTyr447		phosphorylation
up-regulates
→		GAB19890893SIGNOR-236420
INSRphosphorylation
up-regulates
→
GAB1
PTyr447		phosphorylation
up-regulates
→		GAB110978177SIGNOR-251313
Regulator Mechanism/Effect Target SIGNOR-ID
EGFRphosphorylation
→
up-regulates 		GAB1SIGNOR-236420
INSRphosphorylation
→
up-regulates activity 		GAB1SIGNOR-251313