| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | GAB1 | Tyr659 | VADERVDyVVVDQQK | dephosphorylation down-regulates | 10068651 | SIGNOR-236254 |
| PTPN11 | GAB1 | Tyr659 | VADERVDyVVVDQQK | dephosphorylation down-regulates activity | 11323411 | SIGNOR-248675 |
| INSR | GAB1 | Tyr659 | VADERVDyVVVDQQK | phosphorylation up-regulates activity | 10978177 | SIGNOR-251317 |
| MET | GAB1 | Tyr659 | VADERVDyVVVDQQK | phosphorylation up-regulates activity | 10734310 | SIGNOR-250290 |
| EGFR | GAB1 | Tyr659 | VADERVDyVVVDQQK | phosphorylation up-regulates | 9890893 | SIGNOR-236404 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | dephosphorylation down-regulates ⊣ | GAB1 PTyr659 | dephosphorylation up-regulates → | GAB1 | 10068651 | SIGNOR-236254 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GAB1 PTyr659 | dephosphorylation up-regulates → | GAB1 | 11323411 | SIGNOR-248675 |
| INSR | phosphorylation up-regulates → | GAB1 PTyr659 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251317 |
| MET | phosphorylation up-regulates → | GAB1 PTyr659 | phosphorylation up-regulates → | GAB1 | 10734310 | SIGNOR-250290 |
| EGFR | phosphorylation up-regulates → | GAB1 PTyr659 | phosphorylation up-regulates → | GAB1 | 9890893 | SIGNOR-236404 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN11 | dephosphorylation down-regulates | GAB1 | SIGNOR-236254 |
| PTPN11 | dephosphorylation → down-regulates activity | GAB1 | SIGNOR-248675 |
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251317 |
| MET | phosphorylation → up-regulates activity | GAB1 | SIGNOR-250290 |
| EGFR | phosphorylation → up-regulates | GAB1 | SIGNOR-236404 |
