| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | GAB1 | Thr476 | EANYVPMtPGTFDFS | phosphorylation up-regulates activity | 15379552 | SIGNOR-249400 |
| MAPK3 | GAB1 | Thr476 | EANYVPMtPGTFDFS | phosphorylation up-regulates activity | 15379552 | SIGNOR-249464 |
| ERK1/2 | GAB1 | Thr476 | EANYVPMtPGTFDFS | phosphorylation up-regulates activity | 15379552 | SIGNOR-129200 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | GAB1 PThr476 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-249400 |
| MAPK3 | phosphorylation up-regulates → | GAB1 PThr476 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-249464 |
| ERK1/2 | phosphorylation up-regulates → | GAB1 PThr476 | phosphorylation up-regulates → | GAB1 | 15379552 | SIGNOR-129200 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-249400 |
| MAPK3 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-249464 |
| ERK1/2 | phosphorylation → up-regulates activity | GAB1 | SIGNOR-129200 |